{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:48:02Z","timestamp":1779389282684,"version":"3.53.1"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government","award":["MSIT; 2021RIF1A063568"],"award-info":[{"award-number":["MSIT; 2021RIF1A063568"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The terminal 14q32 duplication has been reported often in association with other cytogenetic abnormalities, and individuals with this specific duplication showed varying degrees of developmental delay\/intellectual disability (DD\/ID) and growth retardation (GR), and distinct facial dysmorphisms. Herein, based on the limited cases of terminal duplication of 14q32 known to date, we present new affected siblings presenting with DD\/ID, GR, and facial dysmorphism, as well as cerebral infarction caused by recurrent de novo der(14)t(14;14)(p11.2;q32.1) leading to terminal duplication of 14q32. We used coverage analysis generated via duo exome sequencing, performed chromosomal microarray (CMA) as a confirmatory test, and compared our findings with those reported previously. Coverage analysis generated via duo exome sequencing revealed a 17.2 Mb heterozygous duplication at chromosome 14q32.11-q32.33 with a Z ratio ranging between 0.5 and 1 in the proband and her elder brother. As a complementary method, CMA established a terminal duplication described as the arr[hg19]14q32.11q32.33(90,043,558_107,258,824)x3 in the proband and her elder brother; however, the parents and other siblings showed normal karyotyping and no abnormal gain or loss of CMA results. Five candidate genes, BCL11B, CCNK, YY1, DYNC1H1, and PACS2, were associated with the clinical phenotypes in our cases. Although the parents had normal chromosomes, two affected cases carrying terminal duplication of 14q32 can be explained by gonadal mosaicism. Further studies are needed to establish the association between cerebrovascular events and terminal duplication of chromosome 14q32, including investigation into the cytogenetics of patients with precise clinical descriptions.<\/jats:p>","DOI":"10.3390\/genes12091388","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:24:25Z","timestamp":1631010265000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Recurrent De Novo Terminal Duplication of 14q32 in Korean Siblings Associated with Developmental Delay and Intellectual Disability, Growth Retardation, Facial Dysmorphism, and Cerebral Infarction: A Case Report and Literature Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4174-5266","authenticated-orcid":false,"given":"Ji Yoon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-4234","authenticated-orcid":false,"given":"Joonhong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju 54907, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature01348","article-title":"The DNA sequence and analysis of human chromosome 14","volume":"421","author":"Heilig","year":"2003","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lupski, J.R., and Stankiewicz, P. (2005). Genomic disorders: Molecular mechanisms for rearrangements and conveyed phenotypes. PLoS Genet., 1.","DOI":"10.1371\/journal.pgen.0010049"},{"key":"ref_3","first-page":"8.1.1","article-title":"Overview of Clinical Cytogenetics","volume":"89","author":"Gonzales","year":"2016","journal-title":"Curr. Protoc. Hum. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"R76","DOI":"10.1093\/hmg\/ddu278","article-title":"The impact of chromosomal rearrangements on regulation of gene expression","volume":"23","author":"Harewood","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00326943","article-title":"Familial translocation involving chromosomes 6, 14 and 20, identified by quinacrine fluorescence","volume":"13","author":"Allderdice","year":"1971","journal-title":"Humangenetik"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1136\/jmg.9.3.280","article-title":"Mosaicism with translocation: Autoradiographic and fluorescent studies of an inherited reciprocal translocation t(2q+;14q-)","volume":"9","author":"Reiss","year":"1972","journal-title":"J. Med. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/jmg.9.3.367","article-title":"A case of partial 14 trisomy 47,XY,(14q-)+ and translocation t(9p+;14q-) in mother and brother","volume":"9","author":"Short","year":"1972","journal-title":"J. Med. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00284860","article-title":"Partial trisomy 14 following a balanced reciprocal translocation t(14q-;21q+)","volume":"20","author":"Pfeiffer","year":"1973","journal-title":"Humangenetik"},{"key":"ref_9","first-page":"71","article-title":"Tertiary partial 14 trisomy 47, XX, plus 14q minus","volume":"24","author":"Fryns","year":"1974","journal-title":"Humangenetik"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1601-5223.1974.tb01446.x","article-title":"A prenatally discovered unbalanced translocation t(14;22) (q22 or 23;q13)","volume":"78","author":"Wahlstrom","year":"1974","journal-title":"Hereditas"},{"key":"ref_11","first-page":"35","article-title":"[Partial 14q trisomy. I. Partial 14q trisomy by maternal translocation t(10;14) (p15.2;q22)]","volume":"18","author":"Raoul","year":"1975","journal-title":"Ann. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00293780","article-title":"Partial trisomy 14q due to familial t(14q-,11q+) translocation","volume":"37","author":"Fryns","year":"1977","journal-title":"Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/jmg.14.2.124","article-title":"Partial trisomy 14q -- and parental translocation of No. 14 chromosome. Report of a case and review of the literature","volume":"14","author":"Simpson","year":"1977","journal-title":"J. Med. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajmg.1320010208","article-title":"Pericentric inversion of chromosome 14 and the risk of partial duplication of 14q (14q31 leads to 14qter)","volume":"1","author":"Trunca","year":"1977","journal-title":"Am. J. Med. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00396485","article-title":"Balanced and unbalanced pericentric inversion of a chromosome 14","volume":"43","author":"Pfeiffer","year":"1978","journal-title":"Hum. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/adc.55.6.474","article-title":"A child trisomic for the distal part of chromosome 14q","volume":"55","author":"Bridgman","year":"1980","journal-title":"Arch. Dis. Child."},{"key":"ref_17","first-page":"176","article-title":"[Distal trisomy 14q associated with agenesis of the corpus callosus and truncus arteriosus due to the maternal translocation t(5;14)(q13;q23q32) (author's transl)]","volume":"24","author":"Geormaneanu","year":"1981","journal-title":"Ann. Genet."},{"key":"ref_18","first-page":"145A","article-title":"Familial distal trisomy 14q","volume":"34","author":"Sklower","year":"1982","journal-title":"Am. J. Hum. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ajmg.1320160307","article-title":"Duplication of the distal segment of 14q","volume":"16","author":"Atkin","year":"1983","journal-title":"Am. J. Med. Genet."},{"key":"ref_20","first-page":"635","article-title":"Partial trisomy 14 (q23 leads to qter) via segregation of a 14\/X translocation","volume":"35","author":"Cohen","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1399-0004.1983.tb01885.x","article-title":"Tandem duplication of chromosome 14 (q24 leads to q32) in male newborn with congenital malformations","volume":"23","author":"Nikolis","year":"1983","journal-title":"Clin. Genet."},{"key":"ref_22","first-page":"238","article-title":"Distal trisomy 14q due to tandem duplication (q24 leads to q32)","volume":"26","author":"Orye","year":"1983","journal-title":"Ann. Genet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/jmg.20.6.466","article-title":"Partial trisomy 14q24 leads to qter","volume":"20","author":"Romain","year":"1983","journal-title":"J. Med. Genet."},{"key":"ref_24","first-page":"165","article-title":"[Distal 14q trisomy]","volume":"26","author":"Turleau","year":"1983","journal-title":"Ann. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1399-0004.1984.tb00793.x","article-title":"Familial pericentric inversion (14) (p11;q24) with a rec dup(q) in one offspring","volume":"26","author":"Kaiser","year":"1984","journal-title":"Clin. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1399-0004.1984.tb04373.x","article-title":"Distal trisomy 14q syndrome; a case report","volume":"26","author":"Markkanen","year":"1984","journal-title":"Clin. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00279307","article-title":"Distal duplication 14q: Report of three cases and further delineation of the syndrome","volume":"68","author":"Sklower","year":"1984","journal-title":"Hum. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1136\/jmg.24.6.372","article-title":"Duplication 14(q31----qter)","volume":"24","author":"Carr","year":"1987","journal-title":"J. Med. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/jmg.24.6.380","article-title":"Distal trisomy 14q","volume":"24","author":"Mikelsaar","year":"1987","journal-title":"J. Med. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF01897788","article-title":"Distal 14q trisomy syndrome in two siblings: Further delineation of its phenotype. Jinrui idengaku zasshi","volume":"33","author":"Wakita","year":"1988","journal-title":"Jpn. J. Hum. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/ajmg.1320340415","article-title":"Partial deletion of 14q and partial duplication of 14q in sibs: Testicular mosaicism for t(14q;14q) as a common mechanism","volume":"34","author":"Masada","year":"1989","journal-title":"Am. J. Med. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/BF00193584","article-title":"Distal trisomy 14q. I. Clinical and cytogenetical studies","volume":"85","author":"Gilgenkrantz","year":"1990","journal-title":"Hum. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/BF00210813","article-title":"Partial trisomy of the distal segment 14q","volume":"84","author":"Nakamura","year":"1990","journal-title":"Hum. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/jmg.29.5.299","article-title":"Reverse chromosome painting: A method for the rapid analysis of aberrant chromosomes in clinical cytogenetics","volume":"29","author":"Carter","year":"1992","journal-title":"J. Med. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/jmg.38.5.343","article-title":"Maternally inherited duplication of the possible imprinted 14q31 region","volume":"38","author":"Mugneret","year":"2001","journal-title":"J. Med. Genet."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1034\/j.1399-0004.2001.600306.x","article-title":"Trisomy rescue by postzygotic unbalanced (X;14) translocation in a girl with dysmorphic features","volume":"60","author":"Orellana","year":"2001","journal-title":"Clin. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0003-3995(02)01135-8","article-title":"Distal trisomy 14 (q24 --> qter) and aorto-pulmonary window: A case report and review of the literature","volume":"45","author":"Perrin","year":"2002","journal-title":"Ann. Genet."},{"key":"ref_38","first-page":"313","article-title":"Distal 14q trisomy due to a maternal derivative chromosome 14","volume":"43","author":"Sonoda","year":"2001","journal-title":"Pediatr. Int. Off. J. Jpn. Pediatr. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ajmg.10703","article-title":"Subtelomeric FISH uncovers trisomy 14q32: Lessons for imprinted regions, cryptic rearrangements and variant acrocentric short arms","volume":"112","author":"Sutton","year":"2002","journal-title":"Am. J. Med. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ajmg.a.30997","article-title":"A paternally derived inverted duplication of distal 14q with a terminal 14q deletion","volume":"139a","author":"Chen","year":"2005","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF03195614","article-title":"Recombinant chromosome 14 due to maternal pericentric inversion","volume":"49","author":"Utkus","year":"2008","journal-title":"J. Appl. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ejmg.2008.03.001","article-title":"A de novo 7.6Mb tandem duplication of 14q32.2-qter associated with primordial short stature with neurosecretory growth hormone dysfunction, distinct facial anomalies and mild developmental delay","volume":"51","author":"Thiel","year":"2008","journal-title":"Eur. J. Med. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/ajmg.a.33876","article-title":"A deletion 13q34\/duplication 14q32.2-14q32.33 syndrome diagnosed 50 years after neonatal presentation as infantile hypercalcemia","volume":"155a","author":"Pallister","year":"2011","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tjog.2012.08.002","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial duplication of 14q (14q31.3-->q32.12) associated with abnormal maternal serum biochemistry","volume":"52","author":"Chen","year":"2013","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.gene.2013.03.115","article-title":"A new case of partial 14q31.3-qter trisomy due to maternal pericentric inversion","volume":"523","author":"Sgardioli","year":"2013","journal-title":"Gene"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tjog.2016.06.008","article-title":"Prenatal diagnosis and molecular cytogenetic characterization of a de novo unbalanced reciprocal translocation of der(9)t(9;14)(p24.2;q32.11) associated with 9p terminal deletion and 14q distal duplication","volume":"55","author":"Chen","year":"2016","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000446145","article-title":"A Familial 14q32.32q32.33 Duplication\/17p13.3 Deletion Syndrome with Facial Anomalies and Moderate Intellectual Disability","volume":"148","author":"He","year":"2016","journal-title":"Cytogenet. Genome Res."},{"key":"ref_48","first-page":"00174","article-title":"Terminal 14q Deletion and Duplication with Gastrointestinal and Pulmonary Disease","volume":"5","author":"Santoro","year":"2016","journal-title":"Pediatr Neonatal Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13039-016-0265-5","article-title":"14q32.3-qter trisomic segment: A case report and literature review","volume":"9","author":"Villa","year":"2016","journal-title":"Mol. Cytogenet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/jmedgenet-2019-106377","article-title":"Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: A Chinese cohort","volume":"57","author":"Dong","year":"2020","journal-title":"J. Med. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1002\/ajmg.a.61822","article-title":"Parallel detection of single nucleotide variants and copy number variants with exome analysis: Validation in a cohort of 700 undiagnosed patients","volume":"182","author":"Suzuki","year":"2020","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41436-020-01012-w","article-title":"Cost-effectiveness of genome-wide sequencing for unexplained developmental disabilities and multiple congenital anomalies","volume":"23","author":"Li","year":"2021","journal-title":"Genet. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/gim.2015.156","article-title":"VisCap: Inference and visualization of germ-line copy-number variants from targeted clinical sequencing data","volume":"18","author":"Pugh","year":"2016","journal-title":"Genet. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/jmg.2003.017731","article-title":"Microarray based comparative genomic hybridisation (array-CGH) detects submicroscopic chromosomal deletions and duplications in patients with learning disability\/mental retardation and dysmorphic features","volume":"41","author":"Redon","year":"2004","journal-title":"J. Med. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3343\/alm.2019.39.3.299","article-title":"Chromosomal Microarray Analysis as a First-Tier Clinical Diagnostic Test in Patients With Developmental Delay\/Intellectual Disability, Autism Spectrum Disorders, and Multiple Congenital Anomalies: A Prospective Multicenter Study in Korea","volume":"39","author":"Jang","year":"2019","journal-title":"Ann. Lab. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/pd.1200","article-title":"A novel pericentric inversion of chromosome 14 involving the rRNA gene cluster","volume":"25","author":"Leach","year":"2005","journal-title":"Prenat. Diagn."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajhg.2009.03.010","article-title":"DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl Resources","volume":"84","author":"Firth","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/brain\/awy173","article-title":"BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells","volume":"141","author":"Lessel","year":"2018","journal-title":"Brain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e897","DOI":"10.1002\/mgg3.897","article-title":"A De Novo heterozygous frameshift mutation identified in BCL11B causes neurodevelopmental disorder by whole exome sequencing","volume":"7","author":"Qiao","year":"2019","journal-title":"Mol. Genet. Genomic Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajhg.2018.07.019","article-title":"De Novo Mutations of CCNK Cause a Syndromic Neurodevelopmental Disorder with Distinctive Facial Dysmorphism","volume":"103","author":"Fan","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ajhg.2017.05.006","article-title":"YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction","volume":"100","author":"Gabriele","year":"2017","journal-title":"Am. J. Hum. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/jmedgenet-2011-100542","article-title":"Mutations in DYNC1H1 cause severe intellectual disability with neuronal migration defects","volume":"49","author":"Willemsen","year":"2012","journal-title":"J. Med. Genet."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ng.2613","article-title":"Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly","volume":"45","author":"Poirier","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.ajhg.2018.03.005","article-title":"A Recurrent De Novo PACS2 Heterozygous Missense Variant Causes Neonatal-Onset Developmental Epileptic Encephalopathy, Facial Dysmorphism, and Cerebellar Dysgenesis","volume":"102","author":"Olson","year":"2018","journal-title":"Am. J. Hum. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/ejhg.2017.91","article-title":"New insights into the imprinted MEG8-DMR in 14q32 and clinical and molecular description of novel patients with Temple syndrome","volume":"25","author":"Beygo","year":"2017","journal-title":"Eur. J. Hum. Genet."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/9\/1388\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:58:09Z","timestamp":1760165889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/12\/9\/1388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,7]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["genes12091388"],"URL":"https:\/\/doi.org\/10.3390\/genes12091388","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,7]]}}}