{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:43:17Z","timestamp":1770680597847,"version":"3.49.0"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:00:00Z","timestamp":1634428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["Pq Scholarships"],"award-info":[{"award-number":["Pq Scholarships"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007382","name":"Federal University of Para","doi-asserted-by":"publisher","award":["PROPESP\/Publication Fees."],"award-info":[{"award-number":["PROPESP\/Publication Fees."]}],"id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Acute Lymphoblastic Leukemia (ALL) is a neoplasm of the hematopoietic system defined as a clonal expansion of an abnormal lymphoid precursor cell. It mostly affects children under five years of age and is the most common tumor to afflict pediatric patients. The expression of the human telomerase gene (hTERT) in patients with ALL has been studied as a biomarker and could become a new therapeutic target. We evaluate the role of hTERT gene expression in ALL pediatric patients, through quantitative real-time PCR technique, and the possible correlation between hTERT expression and clinical variables: gender, age, white blood cells (WBC), gene fusions, and immunophenotyping. The analysis between healthy controls and ALL patients (N = 244) was statistically significant (p &lt; 0.001), demonstrating hTERT overexpression in these patients. In comparison with the usual set of clinical variables, the data were not statistically significant (p &gt; 0.05), indicating that hTERT is equally overexpressed among patients regardless of gender, age, gene fusions, and immunophenotyping. Moreover, patients who presented a higher hTERT expression level had a significant (p &lt; 0.0001) lower overall survival rate. In summary, hTERT expression emerges as an important molecular pathway in leukemogenesis regardless patient\u2019s clinical variables, thus, the data here presented pointed it as a valuable biomarker in pediatric acute lymphoblastic leukemia and a promising target for new therapeutic and prognostic measures.<\/jats:p>","DOI":"10.3390\/genes12101632","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:13:32Z","timestamp":1634512412000},"page":"1632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Telomerase (hTERT) Overexpression Reveals a Promising Prognostic Biomarker and Therapeutical Target in Different Clinical Subtypes of Pediatric Acute Lymphoblastic Leukaemia"],"prefix":"10.3390","volume":"12","author":[{"given":"Beatriz Maria Dias","family":"Nogueira","sequence":"first","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laudre\u00edsa","family":"da Costa Pantoja","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oct\u00e1vio Lobo Children\u2019s Hospital, Bel\u00e9m 60430-275, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-8413","authenticated-orcid":false,"given":"Emerson Lucena","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Augusto Rodrigues","family":"Mello J\u00fanior","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Ophir Loyola Hospital, Bel\u00e9m 66063-240, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5102-1811","authenticated-orcid":false,"given":"Eliel Barbosa","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Oncology Research Center, Federal University of Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alayde Vieira","family":"Wanderley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oct\u00e1vio Lobo Children\u2019s Hospital, Bel\u00e9m 60430-275, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5570-3158","authenticated-orcid":false,"given":"Jersey Heitor","family":"da Silva Mau\u00e9s","sequence":"additional","affiliation":[{"name":"Hematology and Transfusion Medicine Center, University of Campinas, Campinas 13083-970, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Odorico","family":"de Moraes Filho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisabete Amaral","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Carvalho","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Salim","family":"Khayat","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Oncology Research Center, Federal University of Par\u00e1, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-3481","authenticated-orcid":false,"given":"Caroline Aquino","family":"Moreira-Nunes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Cear\u00e1, Fortaleza 60430-275, CE, Brazil"},{"name":"Department of Biological Sciences, Oncology Research Center, Federal University of Par\u00e1, Bel\u00e9m 66073-005, PA, 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