{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T15:00:33Z","timestamp":1777820433458,"version":"3.51.4"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>miRNAs are small endogenous conserved non-coding RNA molecules that regulate post-transcriptional gene expression through mRNA degradation or translational inhibition, modulating nearly 60% of human genes. Cystic diseases are characterized by the presence of abnormal fluid-filled sacs in the body, and though most cysts are benign, they can grow inside tumors and turn malignant. Recent evidence has revealed that the aberrant expression of a number of miRNAs present in extracellular fluids, including plasma or serum, urine, saliva, follicular fluid, and semen, contribute to different cystic pathologies. This review aims to describe the role of different miRNAs in three worldwide relevant cystic diseases: polycystic ovarian syndrome (PCOS), polycystic kidney disease (PKD), and pancreatic cyst tumors (PCTs), as well as their potential use as novel biomarkers.<\/jats:p>","DOI":"10.3390\/genes13020191","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:32:52Z","timestamp":1642969972000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Brief Review on the Regulatory Roles of MicroRNAs in Cystic Diseases and Their Use as Potential Biomarkers"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-6921","authenticated-orcid":false,"given":"Luis M.","family":"Ruiz-Manriquez","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schoenstatt Janin","family":"Ledesma Pacheco","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Medina-Gomez","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea G.","family":"Uriostegui-Pena","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. 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San Pablo, Queretaro 76130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anindya","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"C4 Rice Center, International Rice Research Institute, Manila 4031, Philippines"},{"name":"Synthetic Biology, Biofuel and Genome Editing R&D, Reliance Industries Ltd., Navi Mumbai 400701, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7306-1272","authenticated-orcid":false,"given":"Surajit","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Faculty of Allied Health Sciences, Chennai 603103, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antara","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Faculty of Allied Health Sciences, Chennai 603103, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samik","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3979","authenticated-orcid":false,"given":"Aashish","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-7261","authenticated-orcid":false,"given":"Sujay","family":"Paul","sequence":"additional","affiliation":[{"name":"Tecnologico de Monterrey, School of Engineering and Sciences, Campus Queretaro, Av. Epigmenio Gonzalez, No. 500 Fracc. San Pablo, Queretaro 76130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"ref_1","first-page":"1341","article-title":"Residual Cysts: A Brief Literature Review","volume":"5","author":"Tsvetanov","year":"2016","journal-title":"Int. J. Med. Dent. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1096\/fj.201800563RR","article-title":"Impact of miR-192 and miR-194 on cyst enlargement through EMT in autosomal dominant polycystic kidney disease","volume":"33","author":"Kim","year":"2019","journal-title":"FASEB J."},{"key":"ref_3","unstructured":"Newman, T. (2021, August 02). Cysts: Causes, Types, and Treatments. 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