{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:56:46Z","timestamp":1772762206837,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The familial occurrence of childhood cancers has been proven for a long time. Wilms\u2019 tumors often do not have a clear germline genetic cause. However, approximately 2% of all nephroblastoma cases are familial. Descriptions of twins with the same cancer are extremely rare, so our aim was to present the background of the available literature of the occurrence of Wilms\u2019 tumor in a pair of monozygotic twin girls with detailed clinical, histological, and molecular analysis. Two twins were born of unrelated Caucasian parents. Family history revealed no known chronic diseases or malformations. At the age of 3.5 years, the first twin was admitted to the emergency department due to hematuria and abdominal pain. Ultrasound examination revealed an enlarged right kidney, 12.8 cm, with a mass in the upper pole measuring 56 \u00d7 69 \u00d7 78 mm. The second girl was referred for an abdominal ultrasound, which revealed a right kidney measuring 8.6 cm with a central mass measuring 54 \u00d7 45 \u00d7 41 mm. Both children underwent surgical resection, and the histopathological result showed a mixed form of nephroblastoma, predominantly epithelioid with residual blastemal compartment. Detailed clinical, histological, cytogenetic, and molecular analyses were performed on both sisters. It was also decided to identify environmental factors. Information was obtained that the girls\u2019 parents run a farm and regularly use pesticides and chemical rodenticides. Based on our observations and the available literature, Wilms tumor in monozygotic twins may be present. Both genetic and environmental factors may be involved in the development of tumors. After excluding methylation abnormalities and mutations in the genes studied, we questioned whether the onset of Wilms tumor in both sisters could be the result of exposure of the twins\u2019 parents to pesticides.<\/jats:p>","DOI":"10.3390\/genes13020372","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:18:05Z","timestamp":1645431485000},"page":"372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical, Histological, Cytogenetic and Molecular Analysis of Monozygous Twins with Wilms Tumor"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-1732","authenticated-orcid":false,"given":"Katarzyna","family":"Iwa\u0144czyk","sequence":"first","affiliation":[{"name":"Medical Centrum NASMEDICA, 63-000 \u015aroda Wielkopolska, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Czachowski","sequence":"additional","affiliation":[{"name":"Specialist Health Care Center for Mother and Child, 61-825 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4714-6501","authenticated-orcid":false,"given":"Patrycja","family":"Sosnowska-Sienkiewicz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Traumatology and Urology, Poznan University of Medical Sciences, 60-572 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-7524","authenticated-orcid":false,"given":"Gabriela","family":"Telman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 60-572 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Ci\u0105\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Medical Diagnostics Poznan, 60-595 Dobra, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw","family":"Ma\u0144kowski","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Traumatology and Urology, Poznan University of Medical Sciences, 60-572 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2332-2750","authenticated-orcid":false,"given":"Danuta","family":"Januszkiewicz-Lewandowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 60-572 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/1097-0142(196602)19:2<157::AID-CNCR2820190203>3.0.CO;2-#","article-title":"Childhood cancers in twins","volume":"19","author":"Hewitt","year":"1966","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/MPH.0000000000000098","article-title":"Two pairs of monozygotic twins with concordant acute lymphoblastic leukemia (ALL): Case report","volume":"36","author":"Li","year":"2014","journal-title":"J. Pediatric Hematol. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4103\/ijo.IJO_1245_18","article-title":"Retinoblastoma discordance in families with twins","volume":"67","author":"Kim","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/08880018.2013.764559","article-title":"Report of neuroblastoma in a set of monozygotic monochorionic twins","volume":"30","author":"Afshar","year":"2013","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S2352-4642(19)30018-5","article-title":"Identification of new Wilms tumor predisposition genes: An exome sequencing study","volume":"3","author":"Mahamdallie","year":"2019","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1158\/1055-9965.EPI-08-0660","article-title":"Childhood cancer among twins and higher order multiples","volume":"18","author":"Puumala","year":"2009","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0022-5347(17)74374-1","article-title":"Simultaneous Wilms\u2019 tumors in identical twins","volume":"66","author":"Gaulin","year":"1951","journal-title":"J. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/00365599709070352","article-title":"Simultaneous Wilms\u2019 tumors in monozygotic twins: Case report and review of the literature","volume":"31","author":"Svane","year":"1997","journal-title":"Scand. J. Urol. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/01.mph.0000184309.22583.66","article-title":"Wilms tumor in monozygous twins: Clinical, pathogical, cytogenetic and molecular case report","volume":"27","author":"Perotti","year":"2005","journal-title":"J. Pediatric Hematol. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0022-5347(17)63015-5","article-title":"Bilateral nephroblastoma in two sisters","volume":"97","author":"Cochran","year":"1967","journal-title":"J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12262-011-0357-8","article-title":"Familial occurance of nonsyndromic Wilms tumor\u2014A report in two siblings","volume":"75","author":"Begum","year":"2013","journal-title":"Indian J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1200\/JCO.2015.62.1888","article-title":"Advances in Wilms tumor treatment and biology: Progress through international collaboration","volume":"33","author":"Dome","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrurol.2017.163","article-title":"Rationale for the treatment of Wilms tumor in the UMBRELLA SIOP\u2013RTSG 2016 protocol","volume":"14","author":"Hol","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"ref_14","first-page":"155","article-title":"Familial occurrence of Wilms\u2019 tumor: Nephroblastoma in one of monozygous twins and in another sibling","volume":"27","author":"Juberg","year":"1975","journal-title":"Am. J. Hum. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajmg.1320470119","article-title":"Cancer in twins of Wilms\u2019 tumor patients","volume":"47","author":"Olson","year":"1993","journal-title":"Am. J. Med. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/1097-0142(197901)43:1<205::AID-CNCR2820430130>3.0.CO;2-7","article-title":"The role of genetic factors in the etiology of Wilms\u2019 tumor","volume":"43","author":"Maurer","year":"1979","journal-title":"Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/ajmg.a.30015","article-title":"Twenty-four new cases of WT1 germline mutations and review of the literature: Genotype\/phenotype correlations for Wilms tumor development","volume":"127A","author":"Beier","year":"2004","journal-title":"Am. J. Med. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1200\/JCO.2004.02.136","article-title":"Frequency and heritability of WT1 mutations in nonsyndromic Wilms\u2019 tumor patients: A UK Children\u2019s Cancer Study Group Study","volume":"22","author":"Little","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/jmg.2006.041723","article-title":"Syndromes and constitutional chromosomal abnormalities associated with Wilms tumor","volume":"43","author":"Scott","year":"2006","journal-title":"J. Med. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1038\/s41416-019-0594-3","article-title":"Monozygotic twin with neuroblastoma MS have a similar molecular profile: A case of twin-to-twin metastasis","volume":"121","author":"Shatara","year":"2019","journal-title":"Br. J. Cancer."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1016\/j.jpedsurg.2010.08.025","article-title":"Concordance for neuroblastoma in monozygotic twins: Case report and review of the literature","volume":"45","author":"Tajiri","year":"2010","journal-title":"J. Pediatr. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"101706","DOI":"10.1016\/j.canep.2020.101706","article-title":"Environmental exposures related to parental habits in the perinatal period and the risk of Wilms\u2019 tumor in children","volume":"66","author":"Rios","year":"2020","journal-title":"Cancer Epidemiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1289\/ehp.9298","article-title":"Household pesticides and the risk of Wilms tumor","volume":"115","author":"Cooney","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-3016.2010.01133.x","article-title":"Wilms\u2019 tumor: A systematic review of risk factors and meta-analysis","volume":"24","author":"Chu","year":"2010","journal-title":"Paediatr. Perinat. Epidemiol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/2\/372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:22:20Z","timestamp":1760134940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/2\/372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,18]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["genes13020372"],"URL":"https:\/\/doi.org\/10.3390\/genes13020372","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,18]]}}}