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It has been reported that PE is associated with abnormalities in the umbilical cord and cord blood. However, previous studies were focused primarily on the transcriptomics level, while the underlying gene regulatory landscapes are still unclear. Thus, we performed the Assay for Transposase-Accessible Chromatin with high-throughput sequencing (ATAC-seq) using the umbilical cord blood samples collected from a patient with superimposed PE and three healthy donors to uncover the chromatin accessibility changes attributed to PE. We have identified genes associated with immunomodulation and hypoxia response that have higher chromatin accessibility close to their transcription start sites. Motif analysis indicated that the GATA family transcription factor binding was enriched in PE and may play an essential regulatory role in the disease progression. Overall, our findings provide an overview of gene regulatory programs and the corresponding downstream pathways associated with PE that may influence the placenta function and fetal growth.<\/jats:p>","DOI":"10.3390\/genes13050888","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T13:06:23Z","timestamp":1652706383000},"page":"888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preliminary Interpretations of Epigenetic Profiling of Cord Blood in Preeclampsia"],"prefix":"10.3390","volume":"13","author":[{"given":"Junrui","family":"Ma","sequence":"first","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"},{"name":"Faculty of Medical Laboratory Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Cytotherapy Laboratory, The First Affiliated Hospital (Shenzhen People\u2019s Hospital) Southern University of Science and Technology, Shenzhen 518020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaonan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"},{"name":"Department of Neonatology, Shenzhen Guangming Maternity & Child Healthcare Hospital, Shenzhen 518107, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-1675","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen 518106, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommen-dations for International Practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S835","DOI":"10.1016\/j.ajog.2021.11.1371","article-title":"The evolution of the diagnostic criteria of preeclampsia-eclampsia","volume":"226","author":"Tanner","year":"2022","journal-title":"Am. 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Gynecol., 122, 1122\u20131131."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1080\/14767058.2017.1368480","article-title":"Maternal serum and fetal cord-blood ische-mia-modified albumin concentrations in normal pregnancy and preeclampsia: A systematic review and meta-analysis","volume":"31","author":"Duggina","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3109\/14767058.2015.1057811","article-title":"Th1, Th2, Th17 and Treg levels in umbilical cord blood in preeclamp-sia","volume":"29","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1177\/1933719116678692","article-title":"Umbilical Cord Blood Circulating Progenitor Cells and Endothelial Colony-Forming Cells Are Decreased in Preeclampsia","volume":"24","author":"Gumina","year":"2017","journal-title":"Reprod. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"283.e1","DOI":"10.1016\/j.ajog.2015.08.050","article-title":"Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia","volume":"214","author":"Amiel","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wojczakowski, W., Kimber-Trojnar, \u017b., Dziwisz, F., S\u0142odzi\u0144ska, M., S\u0142odzi\u0144ski, H., and Leszczy\u0144ska-Gorzelak, B. (2021). Preeclampsia and Cardiovascular Risk for Offspring. J. Clin. Med., 10.","DOI":"10.3390\/jcm10143154"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1007\/s12035-021-02290-4","article-title":"Preeclampsia and Neurodevelopmental Outcomes: Potential Pathogenic Roles for Inflammation and Oxidative Stress?","volume":"58","author":"Barron","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1353\/cpr.2011.0028","article-title":"Collaborating to Address Infant Mortality: Lessons Learned from the Brownsville Action Community for Health Equality","volume":"5","author":"Holden","year":"2011","journal-title":"Prog. Community Health Partnersh. Res. Educ. Action"},{"key":"ref_14","first-page":"471","article-title":"Early neonatal hypotension in premature infants born to preeclamptic mothers","volume":"26","author":"Teng","year":"2006","journal-title":"J. Perinatol. Off. J. Calif. Perinat. Assoc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.placenta.2009.01.012","article-title":"Differential Placental Gene Expression in Severe Preeclampsia","volume":"30","author":"Sitras","year":"2009","journal-title":"Placenta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"684384","DOI":"10.1155\/2012\/684384","article-title":"Inflammatory Disturbances in Preeclampsia: Relationship between Maternal and Umbilical Cord Blood","volume":"2012","author":"Catarino","year":"2012","journal-title":"J. Pregnancy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41586-021-04249-w","article-title":"RNA profiles reveal signatures of future health and disease in pregnancy","volume":"601","author":"Rasmussen","year":"2022","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/biof.1542","article-title":"The role of epigenetic changes in preeclampsia","volume":"45","author":"Kamrani","year":"2019","journal-title":"BioFactors"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Apicella, C., Ruano, C.S.M., M\u00e9hats, C., Miralles, F., and Vaiman, D. (2019). The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112837"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/AOG.0b013e31825cb96d","article-title":"Abnormal fetal-maternal interactions: An evolutionary value?","volume":"120","author":"Espinoza","year":"2012","journal-title":"Obs. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13148-015-0052-x","article-title":"Genome-scale hypomethylation in the cord blood DNAs associated with early onset preeclampsia","volume":"7","author":"Ching","year":"2015","journal-title":"Clin. Epigenet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/s41576-018-0089-8","article-title":"Chromatin accessibility and the regulatory epigenome","volume":"20","author":"Klemm","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research in-volving human subjects. JAMA, 310, 2191.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Robinson, J.T., Thorvaldsd\u00f3ttir, H., Turner, D., and Mesirov, J.P. (2020). igv.js: An embeddable JavaScript implementation of the Integrative Genomics Viewer (IGV). bioRxiv.","DOI":"10.1101\/2020.05.03.075499"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"W317","DOI":"10.1093\/nar\/gkab447","article-title":"KOBAS-i: Intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis","volume":"49","author":"Bu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/iub.2169","article-title":"GATA factor transcriptional activity: Insights from genome-wide binding profiles","volume":"72","author":"Romano","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.devcel.2011.04.008","article-title":"Genome-wide Analysis of Simultaneous GATA1\/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators","volume":"20","author":"Tijssen","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1182\/blood-2013-03-490425","article-title":"Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes","volume":"122","author":"Beck","year":"2013","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/ncomms2260","article-title":"T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements","volume":"3","author":"Kanhere","year":"2012","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1073\/pnas.1016959108","article-title":"Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart","volume":"108","author":"He","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1038\/onc.2013.517","article-title":"An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer","volume":"33","author":"Sulahian","year":"2013","journal-title":"Oncogene"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1095\/biolreprod.112.102723","article-title":"The Role of Hypoxia and Hypoxia-Inducible Factor-1Alpha in Preeclampsia Pathogenesis","volume":"87","author":"Tal","year":"2012","journal-title":"Biol. Reprod."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2005-0078","article-title":"Molecular evidence of placental hypoxia in preeclampsia","volume":"90","author":"Soleymanlou","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1016\/j.drudis.2021.07.011","article-title":"Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development","volume":"26","author":"Hu","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"214365","DOI":"10.1155\/2011\/214365","article-title":"Maternal Preeclampsia and Neonatal Outcomes","volume":"2011","author":"Backes","year":"2011","journal-title":"J. Pregnancy"},{"key":"ref_39","first-page":"7","article-title":"Platelet Membrane Procoagulation in Preeclampsia","volume":"136","author":"Lee","year":"2020","journal-title":"Blood"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1016\/j.thromres.2009.09.013","article-title":"Platelet activation and endogenous thrombin potential in pre-eclampsia","volume":"125","author":"Macey","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bpobgyn.2019.06.005","article-title":"Immunomodulation and preeclampsia","volume":"60","author":"Rambaldi","year":"2019","journal-title":"Best Pract. Research. Clin. Obstet. Gynaecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1477-7827-1-121","article-title":"Tolerance of the fetus by the maternal immune system: Role of inflammatory mediators at the feto-maternal interface","volume":"1","author":"Caucheteux","year":"2003","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmg026","article-title":"The immunology of successful pregnancy","volume":"9","author":"Heineman","year":"2003","journal-title":"Hum. Reprod. Updat."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1365-2249.1999.00997.x","article-title":"Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia","volume":"117","author":"Saito","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.immuni.2014.06.006","article-title":"GATA-3 Function in Innate and Adaptive Immunity","volume":"41","author":"Tindemans","year":"2014","journal-title":"Immunity"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/MCB.21.8.2716-2725.2001","article-title":"Structure and Specificity of GATA Proteins in Th2 Development","volume":"21","author":"Ranganath","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"103470","DOI":"10.1016\/j.jri.2021.103470","article-title":"DAMPs are able to skew CD4+ T cell subsets and increase the inflammatory profile in pregnant women with preeclampsia","volume":"149","author":"Ribeiro","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/onc.2017.8","article-title":"GATA3 interacts with and stabilizes HIF-1\u03b1 to enhance cancer cell invasiveness","volume":"36","author":"Lin","year":"2017","journal-title":"Oncogene"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/5\/888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:11:20Z","timestamp":1760137880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/5\/888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["genes13050888"],"URL":"https:\/\/doi.org\/10.3390\/genes13050888","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]}}}