{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T02:27:06Z","timestamp":1769740026213,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Ageing is the effect of time on biological entities. It represents a risk factor for a variety of diseases and health disorders; thus, therapeutic options are required to tackle ageing issues. Modern geriatric medicine prescribes exercise to counteract ageing effects. This work presents secreted protein acidic and rich in cysteine (SPARC) as a potential antiageing therapy. Indeed, SPARC declines with ageing, exercise induces SPARC, and SPARC overexpression in mice mimics exercise. Thus, we hypothesize that SPARC is an exercise-induced factor that is beyond\u2014at least part of\u2014the antiageing effects induced by exercise. This could become a potential antiageing therapy for the elderly that counteracts ageing by mimicking the effects of exercise without needing to perform exercise. This is of particular importance because ageing usually reduces mobility and age-related diseases can reduce the ability to perform the required physical activity. On the other hand, the possibilities of mimicking exercise benefits via SPARC are not limited to ageing, and can be applied in various contexts in which exercise cannot be performed because of physical disabilities, health disorders, or limited mobility.<\/jats:p>","DOI":"10.3390\/genes13060950","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T08:50:22Z","timestamp":1653555022000},"page":"950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic Expression between Ageing and Exercise: Secreted Protein Acidic and Rich in Cysteine as a Potential \u201cExercise Substitute\u201d Antiageing Therapy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-1119","authenticated-orcid":false,"given":"Abdelaziz","family":"Ghanemi","sequence":"first","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Quebec, QC G1V 4G2, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-9024","authenticated-orcid":false,"given":"Mayumi","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Quebec, QC G1V 4G2, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-6127","authenticated-orcid":false,"given":"Jonny","family":"St-Amand","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Qu\u00e9bec-Universit\u00e9 Laval Research Center, Quebec, QC G1V 4G2, Canada"},{"name":"Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ghanemi, A., Yoshioka, M., and St-Amand, J. 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