{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:16Z","timestamp":1788544156350,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81941003"],"award-info":[{"award-number":["81941003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021YFA0805902"],"award-info":[{"award-number":["2021YFA0805902"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019YFE0117400"],"award-info":[{"award-number":["2019YFE0117400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022506537"],"award-info":[{"award-number":["2022506537"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["81941003"],"award-info":[{"award-number":["81941003"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFA0805902"],"award-info":[{"award-number":["2021YFA0805902"]}]},{"name":"National Key Research and Development Program of China","award":["2019YFE0117400"],"award-info":[{"award-number":["2019YFE0117400"]}]},{"name":"National Key Research and Development Program of China","award":["2022506537"],"award-info":[{"award-number":["2022506537"]}]},{"name":"Medical Science and Technology Project of Zhejiang Province","award":["81941003"],"award-info":[{"award-number":["81941003"]}]},{"name":"Medical Science and Technology Project of Zhejiang Province","award":["2021YFA0805902"],"award-info":[{"award-number":["2021YFA0805902"]}]},{"name":"Medical Science and Technology Project of Zhejiang Province","award":["2019YFE0117400"],"award-info":[{"award-number":["2019YFE0117400"]}]},{"name":"Medical Science and Technology Project of Zhejiang Province","award":["2022506537"],"award-info":[{"award-number":["2022506537"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Ischemic cardiomyopathy (ICM) caused by coronary artery disease always leads to myocardial infarction and heart failure. Identification of novel transcriptional regulators in ICM is an effective method to establish new diagnostic and therapeutic strategies. In this study, we used two RNA-seq datasets and one microarray dataset from different studies, including 25 ICM and 21 non-failing control (NF) samples of human left ventricle tissues for further analysis. In total, 208 differentially expressed genes (DEGs) were found by combining two RNA-seq datasets with batch effects removed. GO and KEGG analyses of DEGs indicated that the response to wounding, positive regulation of smooth muscle contraction, chromatin, PI3K-Akt signaling pathway, and transporters pathways are involved in ICM. Simple Enrichment Analysis found that NFIC-binding motifs are enriched in promoter regions of downregulated genes. The Gene Importance Calculator further proved that NFIC is vital. NFIC and its downstream genes were verified in the validating microarray dataset. Meanwhile, in rat cardiomyocyte cell line H9C2 cells, two genes (Tspan1 and Hopx) were confirmed, which decreased significantly along with knocking down Nfic expression. In conclusion, NFIC participates in the ICM process by regulating TSPAN1 and HOPX. NFIC and its downstream genes may be marker genes and potential diagnostic and therapeutic targets for ICM.<\/jats:p>","DOI":"10.3390\/genes13061051","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T23:55:24Z","timestamp":1655078124000},"page":"1051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bioinformatics and Experimental Analyses Reveal NFIC as an Upstream Transcriptional Regulator for Ischemic Cardiomyopathy"],"prefix":"10.3390","volume":"13","author":[{"given":"Yang","family":"Ye","sequence":"first","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4084-7068","authenticated-orcid":false,"given":"Qiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-5847","authenticated-orcid":false,"given":"Minghao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-478X","authenticated-orcid":false,"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-8396","authenticated-orcid":false,"given":"Lenan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China"},{"name":"Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11886-021-01520-4","article-title":"Relief of Ischemia in Ischemic Cardiomyopathy","volume":"23","author":"Moroni","year":"2021","journal-title":"Curr. 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