{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:37:48Z","timestamp":1778463468836,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSPS Grant-in-Aid for Young Scientists","award":["18K15754"],"award-info":[{"award-number":["18K15754"]}]},{"name":"internal budget of Saga University Hospital for advanced medical technology","award":["18K15754"],"award-info":[{"award-number":["18K15754"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>There is an association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis, but the genetic risk of atherosclerosis in NAFLD remains unclear. Here, a single-nucleotide polymorphism (SNP) of the heat shock 70 kDa protein 8 (HSPA8) gene was analyzed in 123 NAFLD patients who had been diagnosed using a liver biopsy, and the NAFLD phenotype including the maximum intima\u2013media thickness (Max-IMT) of the carotid artery was investigated. Patients with the minor allele (A\/G or G\/G) of rs2236659 showed a lower serum heat shock cognate 71 kDa protein concentration than those with the major A\/A allele. Compared with the patients with the major allele, those with the minor allele showed a higher prevalence of hypertension and higher Max-IMT in men. No significant associations between the HSPA8 genotype and hepatic pathological findings were identified. In decision-tree analysis, age, sex, liver fibrosis, and HSPA8 genotype were individually associated with severe carotid artery atherosclerosis (Max-IMT \u2265 1.5 mm). Noncirrhotic men aged \u2265 65 years were most significantly affected by the minor allele of HSPA8. To predict the risk of atherosclerosis and cardiovascular disease, HSPA8 SNP genotyping might be useful, particularly for older male NAFLD patients.<\/jats:p>","DOI":"10.3390\/genes13071265","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T22:57:06Z","timestamp":1658098626000},"page":"1265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HSPA8 Single-Nucleotide Polymorphism Is Associated with Serum HSC70 Concentration and Carotid Artery Atherosclerosis in Nonalcoholic Fatty Liver Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Wenli","family":"Zhao","sequence":"first","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"},{"name":"Liver Center, Saga University Hospital Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoe","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Tomiga","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasheda","family":"Perveen","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9759-4148","authenticated-orcid":false,"given":"Keiichiro","family":"Mine","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"},{"name":"Division of Mucosal Immunology, Research Center for Systems Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Inadomi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-1434","authenticated-orcid":false,"given":"Iwata","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"},{"name":"Health Administration Centre, Saga Medical School, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-8358","authenticated-orcid":false,"given":"Seiho","family":"Nagafuchi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Education and Research Center for Community Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Aishima","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keizo","family":"Anzai","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-4389","authenticated-orcid":false,"given":"Hirokazu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 849-8501, Japan"},{"name":"Liver Center, Saga University Hospital Faculty of Medicine, Saga University, Saga 849-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","article-title":"Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. 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