{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:34Z","timestamp":1791288934131,"version":"4.3.0"},"reference-count":78,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2018YFD0900301-10"],"award-info":[{"award-number":["2018YFD0900301-10"]}]},{"name":"National Key R&amp;D Program of China","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}]},{"name":"National Key R&amp;D Program of China","award":["2021RT07"],"award-info":[{"award-number":["2021RT07"]}]},{"name":"National Key R&amp;D Program of China","award":["B202102"],"award-info":[{"award-number":["B202102"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["2018YFD0900301-10"],"award-info":[{"award-number":["2018YFD0900301-10"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["2021RT07"],"award-info":[{"award-number":["2021RT07"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["B202102"],"award-info":[{"award-number":["B202102"]}]},{"name":"Key Field Innovation Team Project of Dalian City, China","award":["2018YFD0900301-10"],"award-info":[{"award-number":["2018YFD0900301-10"]}]},{"name":"Key Field Innovation Team Project of Dalian City, China","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}]},{"name":"Key Field Innovation Team Project of Dalian City, China","award":["2021RT07"],"award-info":[{"award-number":["2021RT07"]}]},{"name":"Key Field Innovation Team Project of Dalian City, China","award":["B202102"],"award-info":[{"award-number":["B202102"]}]},{"name":"Innovation Team Project of Dalian Ocean University, China","award":["2018YFD0900301-10"],"award-info":[{"award-number":["2018YFD0900301-10"]}]},{"name":"Innovation Team Project of Dalian Ocean University, China","award":["CARS-47"],"award-info":[{"award-number":["CARS-47"]}]},{"name":"Innovation Team Project of Dalian Ocean University, China","award":["2021RT07"],"award-info":[{"award-number":["2021RT07"]}]},{"name":"Innovation Team Project of Dalian Ocean University, China","award":["B202102"],"award-info":[{"award-number":["B202102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The brain is considered to be an extremely sensitive tissue to hypoxia, and the brain of fish plays an important role in regulating growth and adapting to environmental changes. As an important aquatic organism in northern China, the economic yield of Takifugu rubripes is deeply influenced by the oxygen content of seawater. In this regard, we performed RNA-seq analysis of T. rubripes brains under hypoxia and normoxia to reveal the expression patterns of genes involved in the hypoxic response and their enrichment of metabolic pathways. Studies have shown that carbohydrate, lipid and amino acid metabolism are significant pathways for the enrichment of differentially expressed genes (DEGs) and that DEGs are significantly upregulated in those pathways. In addition, some biological processes such as the immune system and signal transduction, where enrichment is not significant but important, are also discussed. Interestingly, the DEGs associated with those pathways were significantly downregulated or inhibited. The present study reveals the mechanism of hypoxia tolerance in T. rubripes at the transcriptional level and provides a useful resource for studying the energy metabolism mechanism of hypoxia response in this species.<\/jats:p>","DOI":"10.3390\/genes13081347","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T21:11:05Z","timestamp":1658956265000},"page":"1347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Transcriptome Analysis Identifies Key Metabolic Changes in the Brain of Takifugu rubripes in Response to Chronic Hypoxia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0837-5144","authenticated-orcid":false,"given":"Fengqin","family":"Shang","sequence":"first","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"},{"name":"College of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0332-9923","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengmei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Marine Technology and Environment, Dalian Ocean University, Dalian 116023, China"},{"name":"Key Laboratory of Environment Controlled Aquaculture, Dalian Ocean University, Ministry of Education, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-7706","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pufferfish Breeding and Culture in Liaoning Province, Dalian Ocean University, Dalian 116023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R1512","DOI":"10.1152\/ajpregu.00089.2005","article-title":"Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish","volume":"289","author":"Witte","year":"2005","journal-title":"Am. 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