{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:11:20Z","timestamp":1789067480403,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a pathology characterized by chronic inflammation and skin lesions. The molecular basis of the inflammatory network remains unclear; however, since microRNAs (miRNAs) are involved in the modulation of inflammation, the composition of a micro-transcriptome RNA library using the blood of HS patients was analysed here. The total miRNA expression profiles of miRNAs from HS patients was assayed by real-time qPCR. Here, compared to healthy controls, miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p expression was found significantly different in HS. Knowing the significance of the miRNA mechanism in inflammatory and immune progression, we suggest that miRNA profiles found in HS patients can be significant in understanding the pathogenesis modality and establishing efficient biomarkers for HS early diagnosis. In particular, miR-338-5p was closely related to HS invasiveness and production of cytokines and was atypically overexpressed. miR-338-5p may represent a good promise as a non-invasive clinical biomarker for HS.<\/jats:p>","DOI":"10.3390\/genes13091544","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T01:39:19Z","timestamp":1661737159000},"page":"1544","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Circulating microRNAs in Hidradenitis Suppurativa"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9132-5569","authenticated-orcid":false,"given":"Bruna","family":"De Felice","sequence":"first","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DISTABIF), University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Montanino","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DISTABIF), University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mallardo","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DISTABIF), University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy"},{"name":"CEINGE-Biotecnologie Avanzate, Via G. Salvatore, 486, 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Babino","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Universit\u00e0 Degli Studi della Campania \u201cLuigi Vanvitelli\u201d, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edi","family":"Mattera","sequence":"additional","affiliation":[{"name":"Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, Via Pansini, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-0150","authenticated-orcid":false,"given":"Giovanni","family":"Ragozzino","sequence":"additional","affiliation":[{"name":"Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, Via Pansini, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-8214","authenticated-orcid":false,"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Department of Internal and Experimental Medicine and Surgery Unit of Internal Medicine, Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d, Via Pansini, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Daniele","sequence":"additional","affiliation":[{"name":"CEINGE-Biotecnologie Avanzate, Via G. Salvatore, 486, 80145 Napoli, Italy"},{"name":"Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia","family":"Nigro","sequence":"additional","affiliation":[{"name":"Department of Environmental, Biological and Pharmaceutical Sciences and Technologies (DISTABIF), University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy"},{"name":"CEINGE-Biotecnologie Avanzate, Via G. Salvatore, 486, 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Coates, M., Mariottoni, P., Corcoran, D.L., Kirshner, H.F., Jaleel, T., Brown, D.A., Brooks, S.R., Murray, J., Morasso, M.I., and MacLeod, A.S. (2019). 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