{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:35:48Z","timestamp":1762068948930,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803845","2021ZY0015","NJYT22048","190301"],"award-info":[{"award-number":["81803845","2021ZY0015","NJYT22048","190301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Government Guided Local Scientific and Technological Development Project","award":["81803845","2021ZY0015","NJYT22048","190301"],"award-info":[{"award-number":["81803845","2021ZY0015","NJYT22048","190301"]}]},{"name":"Science and Technology Young Talents Development Project of Inner Mongolia Autonomous Region","award":["81803845","2021ZY0015","NJYT22048","190301"],"award-info":[{"award-number":["81803845","2021ZY0015","NJYT22048","190301"]}]},{"name":"Mongolian Medicine Food and Drug Source Protection and Utilization Innovation Team Construction Project","award":["81803845","2021ZY0015","NJYT22048","190301"],"award-info":[{"award-number":["81803845","2021ZY0015","NJYT22048","190301"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>This study aimed to apply transcriptomics to determine how Molor-Dabos-4 (MD-4) protects healthy rats against indomethacin (IND)-induced gastric ulcers and to identify the mechanism behind this protective effect. Rats were pretreated with MD-4 (0.3, 1.5, or 3 g\/kg per day) for 21 days before inducing gastric ulcers by oral administration with indomethacin (30 mg\/kg). Unulcerated and untreated healthy rats were used as controls. Effects of the treatment were assessed based on the ulcer index, histological and pathological examinations, and indicators of inflammation, which were determined by enzyme-linked immunosorbent assay. Transcriptomic analysis was performed for identifying potential pharmacological mechanisms. Eventually, after identifying potential target genes, the latter were validated by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). After pretreatment with MD-4, gastric ulcers, along with other histopathological features, were reduced. MD-4 significantly (p &lt; 0.05) increased the superoxide dismutase (SOD) levels in ulcers and reduced pepsin, TNF-\u03b1, and IL-6 levels. RNA-seq analysis identified a number of target genes on which MD-4 could potentially act. Many of these genes were involved in pathways that were linked to anti-inflammatory and antioxidant responses, and other protective mechanisms for the gastric mucosa. qRT-PCR showed that altered expression of the selected genes, such as Srm, Ryr-1, Eno3, Prkag3, and Eef1a2, was consistent with the transcriptome results. MD-4 exerts protective effects against IND-induced gastric ulcers by reducing inflammatory cytokines and pepsin and increasing the expression of SOD levels. Downregulation of Srm, Ryr-1, Eno3, Prkag3, and Eef1a2 genes involved in regulating arginine and proline metabolism, calcium signaling pathway, HIF-1 signaling pathway, oxytocin signaling pathway, and legionellosis are possibly involved in MD-4-mediated protection against gastric ulcers.<\/jats:p>","DOI":"10.3390\/genes13101740","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T23:12:12Z","timestamp":1664320332000},"page":"1740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-2183","authenticated-orcid":false,"given":"Terigele","family":"Bao","sequence":"first","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Feng","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-2758","authenticated-orcid":false,"given":"Sungbo","family":"Cho","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhen","family":"Yu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Jin","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Dai","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9446-5615","authenticated-orcid":false,"given":"Junqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8480-5599","authenticated-orcid":false,"given":"Laxinamujila","family":"Bai","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-8744","authenticated-orcid":false,"given":"Minghai","family":"Fu","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"},{"name":"Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"NMPA Key Laboratory of Quality Control of Traditional Chinese Medicine (Mongolian Medicine), School of Mongolian Medicine, Inner Mongolia Minzu University, Tongliao 028000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","first-page":"514","article-title":"The global burden of peptic ulcer disease in 204 countries and territories from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"61","author":"Ren","year":"2022","journal-title":"Int. J. Epidemiol."},{"key":"ref_2","first-page":"1692","article-title":"Serum pharmacochemistry of the effective substance of Jiawei Xiaochaihu Decoction against gastric ulcer","volume":"43","author":"Chen","year":"2018","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: Bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(09)60938-7","article-title":"Peptic ulcer disease","volume":"374","author":"Malfertheiner","year":"2009","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1139\/cjpp-2017-0399","article-title":"Accelerated gastric ulcer healing in thyroxine-treated rats: Roles of gastric acid, mucus, and inflammatory response","volume":"96","author":"Adeniyi","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2036.2009.04086.x","article-title":"Cellular and molecular mechanisms of NSAID-induced peptic ulcers","volume":"30","author":"Musumba","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/pds.3587","article-title":"Effectiveness of interventions by community pharmacists to reduce risk of gastrointestinal side effects in nonselective nonsteroidal anti-inflammatory drug users","volume":"23","author":"Teichert","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/den.12846","article-title":"Novel gastric mucosal findings in association with proton pump inhibitors","volume":"29","author":"Isomoto","year":"2017","journal-title":"Dig. Endosc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4291\/wjgp.v5.i1.40","article-title":"Quality of healing of gastric ulcers: Natural products beyond acid suppression","volume":"5","author":"Kangwan","year":"2014","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Serafim, C., Araruna, M.E., J\u00fanior, E.A., Diniz, M., Hiruma-Lima, C., and Batista, L. (2020). A Review of the Role of Flavonoids in Peptic Ulcer (2010\u20132020). Molecules, 25.","DOI":"10.3390\/molecules25225431"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17020","DOI":"10.3748\/wjg.v20.i45.17020","article-title":"Efficacy and safety of herbal medicines in treating gastric ulcer: A review","volume":"20","author":"Bi","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/jgh.13737","article-title":"Proton pump inhibitors: Risks of long-term use","volume":"32","author":"Eusebi","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2015.02.005","article-title":"Ethnobotanical study of plants used for therapeutic purposes in the Atlantic Forest region, Southern Brazil","volume":"164","author":"Tribess","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"121234","DOI":"10.1016\/j.ijpharm.2021.121234","article-title":"Sequential loading of inclusion complex\/nanoparticles improves the gastric retention of Vladimiriae Radix essential oil to promote the protection of acute gastric mucosal injury","volume":"610","author":"Yan","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15593258211044329","DOI":"10.1177\/15593258211044329","article-title":"SR-5, the specific ratio of Korean multi-herbal formula: An evaluation of antiulcerogenic effects on experimentally induced gastric ulcers in mice","volume":"19","author":"Kim","year":"2021","journal-title":"Dose-Response"},{"key":"ref_16","first-page":"9944685","article-title":"Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation","volume":"2021","author":"Wang","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3748\/wjg.v27.i16.1770","article-title":"Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats","volume":"27","author":"Tong","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_18","unstructured":"Ba, D.R.H., and Li, J. (2012). medical science. Encyclopedia of Mongolian Studies, IM People\u2019s Publishing House. [1st ed.]."},{"key":"ref_19","first-page":"3063","article-title":"Mineralogical exploration of halite mineral drugs","volume":"12","author":"Zhang","year":"2019","journal-title":"Chin. Pat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.foodchem.2015.11.033","article-title":"Comparison of different drying methods on Chinese ginger (Zingiber officinale Roscoe): Changes in volatiles, chemical profile, antioxidant properties, and microstructure","volume":"197","author":"An","year":"2016","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"105350","DOI":"10.1016\/j.actatropica.2020.105350","article-title":"Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis","volume":"205","author":"Mengarda","year":"2020","journal-title":"Acta Trop."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Marques da Fonseca, L., Jacques da Silva, L.R., Santos dos Reis, J., Rodrigues da Costa Santos, M.A., de Sousa Chaves, V., Monteiro da Costa, K., Sa-Diniz, J.d.N., Freire de Lima, C.G., Morrot, A., and Nunes Franklim, T. (2020). Piperine Inhibits TGF-\u03b2 Signaling Pathways and Disrupts EMT-related Events in Human Lung Adenocarcinoma Cells. Medicines, 7.","DOI":"10.3390\/medicines7040019"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0378-8741(02)00099-5","article-title":"Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula Retz. Fruit","volume":"81","author":"Saleem","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00204-006-0139-4","article-title":"Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes","volume":"81","author":"Lee","year":"2007","journal-title":"Arch. Toxicol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ejphar.2007.09.041","article-title":"Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action","volume":"578","author":"Banerjee","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0016-5085(79)80133-X","article-title":"Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine","volume":"76","author":"Guth","year":"1979","journal-title":"Gastroenterology"},{"key":"ref_27","first-page":"203","article-title":"Experience of Mongolian medicine in treating functional dyspepsia based on syndrome differentiation","volume":"19","author":"Mu","year":"2019","journal-title":"Shijie Zuixin Yixue Xinxi Wenzhai"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Shin, J.K., Park, J.H., Kim, K.S., Kang, T.H., and Kim, H.S. (2020). Antiulcer Activity of Steamed Ginger Extract against Ethanol\/HCl-Induced Gastric Mucosal Injury in Rats. Molecules, 25.","DOI":"10.3390\/molecules25204663"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zaghlool, S.S., Abo-Seif, A.A., Rabeh, M.A., Abdelmohsen, U.R., and Messiha, B.A.S. (2019). Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation\/Indomethacin-Induced Ulceration in Rats. Antioxidants, 8.","DOI":"10.3390\/antiox8110512"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jep.2010.06.010","article-title":"Protective effects of methanolic extract of Hedyotis puberula (G. Don) R. Br. ex Arn. against experimentally induced gastric ulcers in rat","volume":"131","author":"Joseph","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","first-page":"356","article-title":"Experimental study on the effects of Guangming salt Siwei Decoction powder on oxidative stress and heme oxygenase-1 expression in atherosclerosis in rats","volume":"34","author":"Li","year":"2012","journal-title":"Neimenggu Yixueyuan Xuebao"},{"key":"ref_32","first-page":"162","article-title":"Protective effect of Guangming salt Siwei Decoction powder on alcoholic liver injury in mice","volume":"30","author":"Bao","year":"2014","journal-title":"Zhongyao Yaoli yu Linchuang"},{"key":"ref_33","first-page":"761","article-title":"The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions","volume":"53","author":"Brzozowski","year":"2002","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0300-483X(02)00514-0","article-title":"The antioxidative and antihistaminic properties of quercetin in ethanol-induced gastric lesions","volume":"183","author":"Kahraman","year":"2003","journal-title":"Toxicology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/13880209.2015.1028079","article-title":"Antibacterial, antioxidant, and topical anti-inflammatory activities of Bergia ammannioides: A wound-healing plant","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.clnu.2015.03.006","article-title":"The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats","volume":"35","author":"Boyacioglu","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111345","DOI":"10.1016\/j.biopha.2021.111345","article-title":"Evaluation of the gastroprotective effects of Chihuahua propolis on indomethacin- induced gastric ulcers in mouse","volume":"137","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0100-879X2002000500003","article-title":"Antioxidant properties of natural compounds used in popular medicine for gastric ulcers","volume":"35","author":"Repetto","year":"2002","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.3748\/wjg.v13.i27.3705","article-title":"Healing property of the Piper betel phenol, allylpyrocatechol against indomethacin-induced stomach ulceration and mechanism of action","volume":"13","author":"Bhattacharya","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bischoff-Kont, I., and F\u00fcrst, R. (2021). Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes. Pharmaceuticals, 14.","DOI":"10.3390\/ph14060571"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s42535-019-00084-7","article-title":"Antioxidant activity of two commercial cultivars of ginger (Zingiber officinale Roscoe): Local Shing and Nadia found in Manipur","volume":"33","author":"Yumnam","year":"2020","journal-title":"Vegetos"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/cre2.467","article-title":"Antibacterial and antioxidant effect of ethanol extracts of Terminalia chebula on Streptococcus mutans","volume":"7","author":"Nam","year":"2021","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.4066\/biomedicalresearch.29-17-3817","article-title":"Piperlongumine attenuates IL-1\u03b2-induced inflammatory response in chondrocytes","volume":"29","author":"Hu","year":"2018","journal-title":"Biomed. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biopha.2017.12.009","article-title":"6-Shogaol attenuates inflammation, cell proliferation via modulate NF-\u03baB and AP-1 oncogenic signaling in 7, 12-dimethylbenz a-anthracene induced oral carcinogenesis","volume":"98","author":"Annamalai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/15569527.2019.1570521","article-title":"Antioxidant Effects of Piperine in in-vivo Chick Embryo Cataract Model Induced by Steroids","volume":"38","author":"Vurmaz","year":"2019","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10753-015-0250-x","article-title":"Piperine Ameliorates Lipopolysaccharideinduced Acute Lung Injury via Modulating NF-\u03baB Signaling Pathways","volume":"39","author":"Lu","year":"2016","journal-title":"Inflammation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1080\/07853890.2021.1981548","article-title":"Protective effect of standardised fruit extract of Garcinia cowa Roxb. ex Choisy against ethanol induced gastric mucosal lesions in Wistar rats","volume":"53","author":"Gupta","year":"2021","journal-title":"Ann. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104627","DOI":"10.1016\/j.phrs.2020.104627","article-title":"Omics strategies decipher therapeutic discoveries of traditional Chinese medicine against different diseases at multiple layers molecular-level","volume":"152","author":"Guo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_49","first-page":"8214052","article-title":"Acupuncture at Back-Shu and Front-Mu Acupoints Prevents Gastric Ulcer by Regulating the TLR4\/MyD88\/NF-\u03baB Signaling Pathway","volume":"2021","author":"Li","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.3748\/wjg.v11.i40.6305","article-title":"Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization","volume":"11","author":"Mizuno","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2017.06.013","article-title":"Gastric expression of IL-17A and IFN\u03b3 in Helicobacter pylori infected individuals is related to symptoms","volume":"99","author":"Adamsson","year":"2017","journal-title":"Cytokine"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yu, W., Tao, M., Zhao, Y., Hu, X., and Wang, M. (2018). 4\u2032-Methoxyresveratrol Alleviated AGE-Induced Inflammation via RAGE-Mediated NF-\u03baB and NLRP3 Inflammasome Pathway. Molecules, 23.","DOI":"10.3390\/molecules23061447"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sarnelli, G., D\u2019Alessandro, A., Iuvone, T., Capoccia, E., Gigli, S., Pesce, M., Seguella, L., Nobile, N., Aprea, G., and Maione, F. (2016). Palmitoylethanolamide modulates inflammation-associated vascular endothelial growth factor (VEGF) signaling via the Akt\/mTOR pathway in a selective peroxisome proliferator-activated receptor \u03b1 (PPAR-\u03b1)-dependent manner. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156198"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopha.2018.07.148","article-title":"Oxytocin improves animal behaviors and ameliorates oxidative stress and inflammation in autistic mice","volume":"107","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"eaan2788","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1159\/000303049","article-title":"Downregulation of the ornithine decarboxylase\/polyamine system inhibits angiotensin-induced hypertrophy of cardiomyocytes through the NO\/cGMP-dependent protein kinase type-I pathway","volume":"25","author":"Lin","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/brain\/awl077","article-title":"Central core disease is due to RYR1 mutations in more than 90% of patients","volume":"129","author":"Wu","year":"2006","journal-title":"Brain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"34822","DOI":"10.1038\/srep34822","article-title":"Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination with Other Gene Mutations","volume":"6","author":"Park","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.freeradbiomed.2019.11.019","article-title":"Mitochondrial oxidative stress induces leaky ryanodine receptor during mechanical ventilation","volume":"146","author":"Dridi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1074\/jbc.M600981200","article-title":"Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins","volume":"281","author":"Lee","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00210-021-02094-2","article-title":"The effect of codeine administration on oxidative stress biomarkers and the expression of the neuron-specific enolase in the brain of Wistar rats","volume":"394","author":"Archibong","year":"2021","journal-title":"Naunyn-Schmiedebergs Arch. Pharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/acel.12093","article-title":"Neuroprotective role of \u03b3-enolase in microglia in a mouse model of Alzheimer\u2019s disease is regulated by cathepsin X","volume":"12","author":"Hafner","year":"2013","journal-title":"Aging Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.288.5469.1248","article-title":"A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle","volume":"288","author":"Milan","year":"2000","journal-title":"Science"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"152855","DOI":"10.1016\/j.tox.2021.152855","article-title":"Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum","volume":"459","author":"Xue","year":"2021","journal-title":"Toxicology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13099-020-00368-3","article-title":"CagA orchestrates eEF1A1 and PKC\u03b4 to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells","volume":"12","author":"Xu","year":"2020","journal-title":"Gut Pathog."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1080\/21655979.2021.1940030","article-title":"Constructing a new prognostic signature of gastric cancer based on multiple data sets","volume":"12","author":"Zhou","year":"2021","journal-title":"Bioengineered"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/BJ20141159","article-title":"Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria","volume":"466","author":"Summitt","year":"2015","journal-title":"Biochem. J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hidalgo-Guti\u00e9rrez, A., Gonz\u00e1lez-Garc\u00eda, P., D\u00edaz-Casado, M.E., Barriocanal-Casado, E., L\u00f3pez-Herrador, S., Quinzii, C.M., and L\u00f3pez, L.C. (2021). Metabolic Targets of Coenzyme Q10 in Mitochondria. Antioxidants, 10.","DOI":"10.3390\/antiox10040520"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0973-1296.204550","article-title":"Multipathway Integrated Adjustment Mechanism of Glycyrrhiza Triterpenes Curing Gastric Ulcer in Rats","volume":"13","author":"Wang","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.tips.2012.01.005","article-title":"Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy","volume":"33","author":"Semenza","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_71","first-page":"696","article-title":"Natural products as potent inhibitors of hypoxia-inducible factor-1\u03b1 in cancer therapy","volume":"18","author":"Zhong","year":"2020","journal-title":"Chin. J. Nat. Med."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/10\/1740\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:30Z","timestamp":1760143230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/13\/10\/1740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":71,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["genes13101740"],"URL":"https:\/\/doi.org\/10.3390\/genes13101740","relation":{},"ISSN":["2073-4425"],"issn-type":[{"type":"electronic","value":"2073-4425"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}