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Genetic abnormalities are likely implicated in the association of ASD and epilepsy, although they are currently detectable in only a small percentage of patients, and some known genetic and medical conditions are associated with ASD and epilepsy. There is no specificity of seizure type to be expected in children and adolescents with ASD compared with other neurodevelopmental disorders or epileptic syndromes. Treatment options include antiepileptic drugs (AED) and developmentally-based early interventions for ASD. Carbamazepine and lamotrigine are the most used AED, but further studies are needed to more precisely define the most suitable medications for this specific group of children with ASD.<\/jats:p>","DOI":"10.3390\/genes13101821","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T20:43:21Z","timestamp":1665261801000},"page":"1821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Autism with Epilepsy: A Neuropsychopharmacology Update"],"prefix":"10.3390","volume":"13","author":[{"given":"Roberto","family":"Canitano","sequence":"first","affiliation":[{"name":"Division of Child and Adolescent Neuropsychiatry, University Hospital of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4077-5700","authenticated-orcid":false,"given":"Roberto","family":"Palumbi","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences, Neurosciences, and Sensory Organs Department, University of Bari \u201cAldo Moro\u201d, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Scandurra","sequence":"additional","affiliation":[{"name":"Division of Child and Adolescent Neuropsychiatry, University Hospital of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yebeh.2019.07.037","article-title":"The co-occurrence of epilepsy and autism: A systematic review","volume":"98 Pt A","author":"Lukmanji","year":"2019","journal-title":"Epilepsy Behav."},{"key":"ref_2","first-page":"33","article-title":"Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis","volume":"13","author":"Liu","year":"2021","journal-title":"Autism"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopsych.2008.04.030","article-title":"Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis","volume":"64","author":"Amiet","year":"2008","journal-title":"Biol. 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