{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:19:15Z","timestamp":1792135155904,"version":"4.4.0"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CY-Biobank","award":["857122"],"award-info":[{"award-number":["857122"]}]},{"name":"CY-Biobank","award":["2016-2020\/INTEGRATED\/0918\/0043"],"award-info":[{"award-number":["2016-2020\/INTEGRATED\/0918\/0043"]}]},{"name":"CY-Biobank","award":["2016-2020\/EXCELLENCE\/1216\/0417"],"award-info":[{"award-number":["2016-2020\/EXCELLENCE\/1216\/0417"]}]},{"name":"CY-Biobank","award":["POST-DOC\/0916\/0190"],"award-info":[{"award-number":["POST-DOC\/0916\/0190"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["857122"],"award-info":[{"award-number":["857122"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["2016-2020\/INTEGRATED\/0918\/0043"],"award-info":[{"award-number":["2016-2020\/INTEGRATED\/0918\/0043"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["2016-2020\/EXCELLENCE\/1216\/0417"],"award-info":[{"award-number":["2016-2020\/EXCELLENCE\/1216\/0417"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["POST-DOC\/0916\/0190"],"award-info":[{"award-number":["POST-DOC\/0916\/0190"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["857122"],"award-info":[{"award-number":["857122"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["2016-2020\/INTEGRATED\/0918\/0043"],"award-info":[{"award-number":["2016-2020\/INTEGRATED\/0918\/0043"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["2016-2020\/EXCELLENCE\/1216\/0417"],"award-info":[{"award-number":["2016-2020\/EXCELLENCE\/1216\/0417"]}]},{"name":"Cyprus Research and Innovation Foundation","award":["POST-DOC\/0916\/0190"],"award-info":[{"award-number":["POST-DOC\/0916\/0190"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Alport syndrome is a hereditary kidney disease caused by mutations in the three genes encoding for collagen IV: COL4A3, COL4A4, and COL4A5. Several mouse models have been created for the study of this disease with variable phenotypic outcomes. This review is an up-to-date presentation of the current mouse models existing in the literature with a detailed comparison of the phenotypic features characterizing each model. Although in humans it is primarily a glomerulopathy, data suggest that in some mouse models, the initial symptoms appear in the tubule-interstitial region rather than the glomerulus. Additionally, in some other models, the severity of disease in the tubule-interstitial region is affected by the genetic background. In conclusion, the phenotypic spectrum of each model appears to be affected by the model\u2019s genetic background, the position of the genetic alteration within the gene, and the type of the genetic alteration. Despite these disparities, mouse models recapitulate with relatively high fidelity several features of the human disease, which makes them useful for studies aimed at better understanding cellular pathomechanisms and for finding new treatments.<\/jats:p>","DOI":"10.3390\/genes13101893","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T21:18:02Z","timestamp":1666127882000},"page":"1893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Comparative Presentation of Mouse Models That Recapitulate Most Features of Alport Syndrome"],"prefix":"10.3390","volume":"13","author":[{"given":"Stavros","family":"Nikolaou","sequence":"first","affiliation":[{"name":"Biobank.cy Center of Excellence in Biobanking and Biomedical Research, University of Cyprus, Nicosia 2109, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Deltas","sequence":"additional","affiliation":[{"name":"Biobank.cy Center of Excellence in Biobanking and Biomedical Research, University of Cyprus, Nicosia 2109, Cyprus"},{"name":"School of Medicine, University of Cyprus, Nicosia 2109, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1136\/bmj.1.3454.504","article-title":"Hereditary Familial Congenital Haemorrhagic Nephritis","volume":"1","author":"Alport","year":"1927","journal-title":"Br. 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