{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:45:59Z","timestamp":1782877559240,"version":"3.54.5"},"reference-count":15,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The guidelines for management of children with 22q11.2 deletion syndrome (22q11DS) highlight the risk for developing hypocalcemia after surgery and recommend monitoring calcium perioperatively. Despite this guidance, little has been published on postoperative hypocalcemia and 22q11DS. Our goals were to evaluate the frequency of perioperative calcium monitoring and examine how often postoperative hypocalcemia was identified. This is a retrospective chart review of patients in our 22q Center\u2019s repository. Inclusion criteria were a diagnosis of 22q11DS and a history of a non-cardiac surgical procedure. Data collected included all non-cardiac surgeries and perioperative calcium labs. In total, 68 patients were included and underwent 305 on-cardiac surgeries. Patients in only 17% of these surgeries had postoperative calcium testing, but of those tested, 58% showed hypocalcemia. Patients with history of hypocalcemia at the time of chart review undergoing non-cardiac surgeries were tested postoperatively 40% of the time; however, 67% of these had hypocalcemia. Similarly, for patients without history of hypocalcemia, postoperative testing occurred 60% of the time, with 52% of these having hypocalcemia. This study demonstrates that postoperative hypocalcemia in children with 22q11DS following non-cardiac surgeries is common and affects patients both with and without prior history of hypocalcemia. These data support establishing a protocol for perioperative testing\/management of hypocalcemia for patients with 22q11DS.<\/jats:p>","DOI":"10.3390\/genes13101905","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T20:35:55Z","timestamp":1666298155000},"page":"1905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Postoperative Hypocalcemia following Non-Cardiac Surgical Procedures in Children with 22q11.2 Deletion Syndrome"],"prefix":"10.3390","volume":"13","author":[{"given":"Jill M.","family":"Arganbright","sequence":"first","affiliation":[{"name":"Division of Pediatric Otolaryngology, Children\u2019s Mercy Hospital, Kansas City, MO 64108, USA"},{"name":"School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-6889","authenticated-orcid":false,"given":"Meghan","family":"Tracy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology, Children\u2019s Mercy Hospital, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Feldt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Children\u2019s Mercy Hospital, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-7579","authenticated-orcid":false,"given":"Srivats","family":"Narayanan","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-4398","authenticated-orcid":false,"given":"Ashna","family":"Mahadev","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janelle","family":"Noel-MacDonnell","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA"},{"name":"Health Services and Outcomes Research, Children\u2019s Mercy Hospital, Kansas City, MO 64108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jpeds.2011.02.039","article-title":"Practical guidelines for managing patients with 22q11.2 deletion syndrome","volume":"159","author":"Bassett","year":"2011","journal-title":"J. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00125817-200101000-00006","article-title":"Phenotype of the 22q11.2 deletion in individuals identified through an affected relative: Cast a wide FISHing net!","volume":"3","author":"Tonnesen","year":"2001","journal-title":"Genet. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00431-004-1577-8","article-title":"Presenting phenotype in 100 children with the 22q11 deletion syndrome","volume":"164","author":"Oskarsdottir","year":"2005","journal-title":"Eur. J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1136\/jmg.34.10.798","article-title":"Spectrum of clinical features associated with interstitial chromosome 22q11 deletions: A European collaborative study","volume":"34","author":"Ryan","year":"1997","journal-title":"J. Med. 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Forum."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1007\/s00246-017-1713-7","article-title":"The Impact of 22q11.2 Microdeletion on Cardiac Surgery Postoperative Outcome","volume":"38","author":"Cuturilo","year":"2017","journal-title":"Pediatr. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Putotto, C., Pugnaloni, F., Unolt, M., Maiolo, S., Trezzi, M., Digilio, M.C., Cirillo, A., Limongelli, G., Marino, B., and Calcagni, G. (2022). 22q11.2 Deletion Syndrome: Impact of Genetics in the Treatment of Conotruncal Heart Defects. 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