{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:27:15Z","timestamp":1772252835437,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["IRR\/2018\/000025"],"award-info":[{"award-number":["IRR\/2018\/000025"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Systems genetics is key for integrating a large number of variants associated with diseases. Vitamin K (VK) is one of the scarcely studied disease conditions. In this work, we ascertained the differentially expressed genes (DEGs) and variants associated with individual subpopulations of VK disease phenotypes, viz., myocardial infarction, renal failure and prostate cancer. We sought to ask whether or not any DEGs harbor pathogenic variants common in these conditions, attempt to bridge the gap in finding characteristic biomarkers and discuss the role of long noncoding RNAs (lncRNAs) in the biogenesis of VK deficiencies.<\/jats:p>","DOI":"10.3390\/genes13112078","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:03:58Z","timestamp":1668045838000},"page":"2078","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inferring bona fide Differentially Expressed Genes and Their Variants Associated with Vitamin K Deficiency Using a Systems Genetics Approach"],"prefix":"10.3390","volume":"13","author":[{"given":"Shalini","family":"Rajagopal","sequence":"first","affiliation":[{"name":"Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Clappana 690525, India"},{"name":"Bioclues.org, Hyderabad 500072, India"},{"name":"Department of Biotechnology, Vignan\u2019s Foundation for Science, Technology & Research, Vadlamudi, Guntur 522213, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akanksha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics, AIIMS, New Delhi 110029, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Simlot","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Pandit Deen Dayal Upadhyaya Hospital (Gangori), Jaipur 302007, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, SMS Medical College, JLN Marg, Jaipur 302004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-3174","authenticated-orcid":false,"given":"Sudhir","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Medicine, SMS Medical College, JLN Marg, Jaipur 302004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Babu Jagjivan Ram Memorial Hospital, Delhi 110033, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalaja","family":"Naravula","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vignan\u2019s Foundation for Science, Technology & Research, Vadlamudi, Guntur 522213, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7099-7721","authenticated-orcid":false,"given":"Krishna","family":"Medicherla","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India"},{"name":"Department of Biotechnology Birla Institute of Technology Mesra, Off Campus Jaipur, Jaipur 302017, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Vignan\u2019s Foundation for Science, Technology & Research, Vadlamudi, Guntur 522213, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-0835","authenticated-orcid":false,"given":"Uma","family":"Kanga","sequence":"additional","affiliation":[{"name":"Department of Transplant Immunology and Immunogenetics, 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