{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:24:46Z","timestamp":1771298686223,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Performance Incentive and Guidance Special Project of Scientific Research Organization of Chongqing Science and Technology Committee","award":["cstc2021jxjl8001"],"award-info":[{"award-number":["cstc2021jxjl8001"]}]},{"name":"Performance Incentive and Guidance Special Project of Scientific Research Organization of Chongqing Science and Technology Committee","award":["2020YFN0024"],"award-info":[{"award-number":["2020YFN0024"]}]},{"name":"Performance Incentive and Guidance Special Project of Scientific Research Organization of Chongqing Science and Technology Committee","award":["2021ZDZX0008"],"award-info":[{"award-number":["2021ZDZX0008"]}]},{"name":"Performance Incentive and Guidance Special Project of Scientific Research Organization of Chongqing Science and Technology Committee","award":["2021YFYZ0030"],"award-info":[{"award-number":["2021YFYZ0030"]}]},{"name":"Sichuan Science and Technology Program","award":["cstc2021jxjl8001"],"award-info":[{"award-number":["cstc2021jxjl8001"]}]},{"name":"Sichuan Science and Technology Program","award":["2020YFN0024"],"award-info":[{"award-number":["2020YFN0024"]}]},{"name":"Sichuan Science and Technology Program","award":["2021ZDZX0008"],"award-info":[{"award-number":["2021ZDZX0008"]}]},{"name":"Sichuan Science and Technology Program","award":["2021YFYZ0030"],"award-info":[{"award-number":["2021YFYZ0030"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Intrauterine growth restriction (IUGR) is a major problem associated with piglet growth performance. The incidence of IUGR is widespread in Rongchang pigs. The pituitary gland is important for regulating growth and metabolism, and research has identified genes associated with growth and development. The pituitary gland of newborn piglets with normal birth weight (NBW group, n = 3) and (IUGR group, n = 3) was collected for transcriptome analysis. A total of 323 differentially expression genes (DEGs) were identified (|log2(fold-change)| &gt; 1 and q value &lt; 0.05), of which 223 were upregulated and 100 were downregulated. Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses showed that the DEGs were mainly related to the extracellular matrix, regulation of the multicellular organismal process, tissue development and angiogenesis, which participate in the growth and immune response in IUGR piglets. Moreover, 7 DEGs including IGF2, THBS1, ITGA1, ITGA8, EPSTI1, FOSB, and UCP2 were associated with growth and immune response. Furthermore, based on the interaction network analysis of the DEGs, two genes, IGF2 and THBS1, participated in cell proliferation, embryonic development and angiogenesis. IGF2 and THBS1 were also the main genes participating in the IUGR. This study identified the core genes involved in IUGR in piglets and provided a reference for exploring the effect of the pituitary gland on piglet growth.<\/jats:p>","DOI":"10.3390\/genes13112141","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:35:23Z","timestamp":1668742523000},"page":"2141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pituitary-Gland-Based Genes Participates in Intrauterine Growth Restriction in Piglets"],"prefix":"10.3390","volume":"13","author":[{"given":"Xiang","family":"Ji","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingxian","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences, Chongqing 402460, China"},{"name":"National Center of Technology Innovation for Pigs, Chongqing 402460, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Chongqing Animal Husbandry and Technology Diffusion Centre, Chongqing 401120, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences, Chongqing 402460, China"},{"name":"National Center of Technology Innovation for Pigs, Chongqing 402460, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyong","family":"Wang","sequence":"additional","affiliation":[{"name":"Chongqing Academy of Animal Sciences, Chongqing 402460, China"},{"name":"National Center of Technology Innovation for Pigs, Chongqing 402460, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"ref_1","first-page":"165","article-title":"Predictive factors for intrauterine growth restriction","volume":"7","author":"Albu","year":"2014","journal-title":"J. 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