{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:49:39Z","timestamp":1760244579145,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Specific University Research","award":["project \u2018Hodnocen\u00ed diagnostick\u00fdch a terapeutick\u00fdch metod u pacient\u016f s vybran\u00fdmi ko\u017en\u00edmi nemocemi\u2019, number 1420\/2016","\u2018Patofyziologick\u00e9 biomarkery u komplexn\u00edch nemoc\u00ed\u2019, number 1401\/2016"],"award-info":[{"award-number":["project \u2018Hodnocen\u00ed diagnostick\u00fdch a terapeutick\u00fdch metod u pacient\u016f s vybran\u00fdmi ko\u017en\u00edmi nemocemi\u2019, number 1420\/2016","\u2018Patofyziologick\u00e9 biomarkery u komplexn\u00edch nemoc\u00ed\u2019, number 1401\/2016"]}]},{"name":"Ministry of Education, Youth and Sports of the Czech Republic","award":["project \u2018Hodnocen\u00ed diagnostick\u00fdch a terapeutick\u00fdch metod u pacient\u016f s vybran\u00fdmi ko\u017en\u00edmi nemocemi\u2019, number 1420\/2016","\u2018Patofyziologick\u00e9 biomarkery u komplexn\u00edch nemoc\u00ed\u2019, number 1401\/2016"],"award-info":[{"award-number":["project \u2018Hodnocen\u00ed diagnostick\u00fdch a terapeutick\u00fdch metod u pacient\u016f s vybran\u00fdmi ko\u017en\u00edmi nemocemi\u2019, number 1420\/2016","\u2018Patofyziologick\u00e9 biomarkery u komplexn\u00edch nemoc\u00ed\u2019, number 1401\/2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Aim: Cutaneous T-cell lymphoma (CTCL) is a group of T-cell malignancies that develop in the skin. Though studied intensively, the etiology and pathogenesis of CTCL remain elusive. This study evaluated the survival of CTCL patients in the 1st Department of Dermatovenereology of St. Anne\u2019s University Hospital Brno. It included analysis of 19 polymorphic gene variants based on their expected involvement in CTCL severity. Material and methods: 75 patients with CTCL, evaluated and treated at the 1st Department of Dermatovenereology of St. Anne\u00b4s University Hospital Brno, Faculty of Medicine, Masaryk University, were recruited for the study over the last 28 years (44 men and 31 women, average age 58 years, range 20\u201382 years). All patients were genotyped for 19 chosen gene polymorphisms by the conventional PCR method with restriction analysis. A multivariate Cox regression model was calculated to reveal genetic polymorphisms and other risk factors for survival. Results: The model identified MDR Ex21 2677 (rs2032582) as a significant genetic factor influencing the survival of the patients, with the T-allele playing a protective role. A multivariate stepwise Cox regression model confirmed the following as significant independent risk factors for overall survival: increased age at admission, clinical staging of the tumor, and male sex. Conclusion: We showed that the TT genotype at position 2677 of the MDR1 gene exhibited statistically significant longer survival in CTCL patients. As such, the TT genotype of MDR1 confers a significant advantage for the CTCL patients who respond to treatment.<\/jats:p>","DOI":"10.3390\/genes13122401","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T06:58:29Z","timestamp":1671433109000},"page":"2401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Some New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma"],"prefix":"10.3390","volume":"13","author":[{"given":"Vladim\u00edr","family":"Va\u0161k\u016f","sequence":"first","affiliation":[{"name":"1st Department of Dermatovenereology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 65691 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-3145","authenticated-orcid":false,"given":"Jan","family":"M\u00e1chal","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Zl\u00e1mal","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-5823","authenticated-orcid":false,"given":"Anna","family":"Va\u0161k\u016f","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/exd.13701","article-title":"Molecular pathogenesis of cutaneous lymphomas","volume":"27","author":"Stadler","year":"2018","journal-title":"Exp. 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