{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:37:29Z","timestamp":1779334649392,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The clinical heterogeneity regarding the response profile of the antitumor necrosis factor (anti-TNF) in patients with Crohn\u2019s disease (CD) and psoriasis (PsO) is attributed, amongst others, to genetic factors that influence the regulatory mechanisms which orchestrate the inflammatory response. Here, we investigated the possible associations between the MIR146A rs2910164 and MIR155 rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the MIR146A rs2910164, while Tsp45I was employed for the MIR155 rs767649 variant. Additionally, we investigated the potential functional role of the rs767649 variant, exploring in silico the alteration of transcription factor binding sites (TFBSs) mapped on its genomic location. Our single-SNP analysis displayed a significant association between the rare rs767649 A allele and response to therapy (Bonferroni-corrected p value = 0.012) in patients with PsO, a result further enhanced by the alteration in the IRF2 TFBS caused by the above allele. Our results highlight the protective role of the rare rs767649 A allele in the clinical remission of PsO, implying its utilization as a pharmacogenetic biomarker.<\/jats:p>","DOI":"10.3390\/genes14020445","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T03:52:49Z","timestamp":1676001169000},"page":"445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacogenetic Analysis of the MIR146A rs2910164 and MIR155 rs767649 Polymorphisms and Response to Anti-TNF Treatment in Patients with Crohn\u2019s Disease and Psoriasis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-1997","authenticated-orcid":false,"given":"Paraskevi","family":"Nani","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2775-7479","authenticated-orcid":false,"given":"Melpomeni","family":"Ladopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-6379","authenticated-orcid":false,"given":"Evgenia H.","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia D.","family":"Papagianni","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-9367","authenticated-orcid":false,"given":"Charalabos","family":"Antonatos","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4244-5940","authenticated-orcid":false,"given":"Panagiotis","family":"Xiropotamos","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Kapsoritakis","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University General Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros S.","family":"Potamianos","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, University General Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Karmiris","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cVenizeleio Pananeio\u201d General Hospital of Heraklion, 71409 Heraklion, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charalambos","family":"Tzathas","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cTzaneio\u201d General Hospital of Piraeus, 18536 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-2001","authenticated-orcid":false,"given":"Aikaterini","family":"Patsatsi","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, Medical School, Papageorgiou Hospital, Aristotle University, 56403 Thessaloniki, Greece"},{"name":"BioPsorAD Consortium, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisavet","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"2nd Dermatology Department, Medical School, Papageorgiou Hospital, Aristotle University, 56403 Thessaloniki, Greece"},{"name":"BioPsorAD Consortium, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efterpi","family":"Zafiriou","sequence":"additional","affiliation":[{"name":"BioPsorAD Consortium, 26504 Patras, Greece"},{"name":"Department of Dermatology, University General Hospital Larissa, University of Thessaly, 41334 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angeliki","family":"Roussaki-Schulze","sequence":"additional","affiliation":[{"name":"BioPsorAD Consortium, 26504 Patras, Greece"},{"name":"Department of Dermatology, University General Hospital Larissa, University of Thessaly, 41334 Larissa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Georgiou","sequence":"additional","affiliation":[{"name":"BioPsorAD Consortium, 26504 Patras, Greece"},{"name":"Dermatology Department, Medical School, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Grafanaki","sequence":"additional","affiliation":[{"name":"BioPsorAD Consortium, 26504 Patras, Greece"},{"name":"Dermatology Department, Medical School, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios K.","family":"Georgakilas","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"},{"name":"Laboratory of Hygiene and Epidemiology, Department of Clinical and Laboratory Research, Faculty of Medicine, University of Thessaly, 38334 Volos, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiannis","family":"Vasilopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece"},{"name":"BioPsorAD Consortium, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-\u039aB by TNF Family Cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.gtc.2017.05.002","article-title":"Crohn\u2019s Disease","volume":"46","author":"Wang","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Antonatos, C., Grafanaki, K., Asmenoudi, P., Xiropotamos, P., Nani, P., Georgakilas, G.K., Georgiou, S., and Vasilopoulos, Y. (2022). Contribution of the Environment, Epigenetic Mechanisms and Non-Coding RNAs in Psoriasis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081934"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13062-020-00280-5","article-title":"Pathophysiology of Crohn\u2019s Disease Inflammation and Recurrence","volume":"15","author":"Petagna","year":"2020","journal-title":"Biol. Direct."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.mayocp.2017.04.010","article-title":"Crohn Disease: Epidemiology, Diagnosis, and Management","volume":"92","author":"Feuerstein","year":"2017","journal-title":"Mayo Clin. Proc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3389\/fphar.2017.00460","article-title":"Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.12788\/j.sder.2018.039","article-title":"TNF Inhibitors for Psoriasis","volume":"37","author":"Chima","year":"2018","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Adegbola, S.O., Sahnan, K., Warusavitarne, J., Hart, A., and Tozer, P. (2018). Anti-TNF Therapy in Crohn\u2019s Disease. Int. J. Mol. 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WJG"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.15171\/mejdd.2020.158","article-title":"Efficacy of Anti-TNF Therapy for the Treatment of Patients with Moderate-to-Severe Inflammatory Bowel Disease; a First Iranian Report","volume":"12","author":"Alatab","year":"2019","journal-title":"Middle East J. Dig. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jaad.2016.02.1221","article-title":"Systematic Review of Efficacy of Anti\u2013Tumor Necrosis Factor (TNF) Therapy in Patients with Psoriasis Previously Treated with a Different Anti\u2013TNF Agent","volume":"75","author":"Yamauchi","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13148-021-01089-3","article-title":"The Role of Epigenetic Modifications for the Pathogenesis of Crohn\u2019s Disease","volume":"13","author":"Hornschuh","year":"2021","journal-title":"Clin. Epigenet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and Autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/art.23386","article-title":"Altered Expression of MicroRNA in Synovial Fibroblasts and Synovial Tissue in Rheumatoid Arthritis","volume":"58","author":"Stanczyk","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/art.23429","article-title":"Expression of MicroRNA-146 in Rheumatoid Arthritis Synovial Tissue","volume":"58","author":"Nakasa","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA Profiling of Multiple Sclerosis Lesions Identifies Modulators of the Regulatory Protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000369695","article-title":"Genetic Association of MiR-146a with Multiple Sclerosis Susceptibility in the Chinese Population","volume":"35","author":"Li","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.7150\/ijbs.59904","article-title":"Roles of MicroRNAs in Inflammatory Bowel Disease","volume":"17","author":"Jung","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3389\/fimmu.2014.00578","article-title":"MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response","volume":"5","author":"Saba","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Maciak, K., Dziedzic, A., Miller, E., and Saluk-Bijak, J. (2021). MiR-155 as an Important Regulator of Multiple Sclerosis Pathogenesis. A Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094332"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"205873842093374","DOI":"10.1177\/2058738420933742","article-title":"Upregulation of the MiRNA-155, MiRNA-210, and MiRNA-20b in Psoriasis Patients and Their Relation to IL-17","volume":"34","author":"Amin","year":"2020","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.gene.2016.10.002","article-title":"The Rs767649 Polymorphism in the Promoter of MiR-155 Contributes to the Decreased Risk for Cervical Cancer in a Chinese Population","volume":"595","author":"Wang","year":"2016","journal-title":"Gene"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/carcin\/bgn195","article-title":"A Functional Polymorphism in the MiR-146a Gene Is Associated with the Risk for Hepatocellular Carcinoma","volume":"29","author":"Xu","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3389\/fgene.2020.00886","article-title":"Association between the MiR-146a Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population","volume":"11","author":"Zou","year":"2020","journal-title":"Front. Genet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4292\/wjgpt.v8.i4.193","article-title":"Association of MiR-146 Rs2910164, MiR-196a Rs11614913, MiR-221 Rs113054794 and MiR-224 Rs188519172 Polymorphisms with Anti-TNF Treatment Response in a Greek Population with Crohn\u2019s Disease","volume":"8","author":"Papaconstantinou","year":"2017","journal-title":"WJGPT"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/FPC.0000000000000471","article-title":"Pharmacogenetic Analysis of Canonical versus Noncanonical Pathway of NF-KB in Crohn\u2019s Disease Patients under Anti-Tumor Necrosis Factor-\u03b1 Treatment","volume":"32","author":"Stavrou","year":"2022","journal-title":"Pharm. Genom."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8179415","DOI":"10.1155\/2020\/8179415","article-title":"The MiR-146a SNP Rs2910164 and MiR-155 SNP Rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population","volume":"2020","author":"Dezfuli","year":"2020","journal-title":"Can. Respir. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.gene.2011.07.006","article-title":"No Association of Pre-MicroRNA-146a Rs2910164 Polymorphism and Risk of Hepatocellular Carcinoma Development in Turkish Population: A Case-Control Study","volume":"486","author":"Bayram","year":"2011","journal-title":"Gene"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: The 9th Release of the Open-Access Database of Transcription Factor Binding Profiles","volume":"50","author":"Rauluseviciute","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/bioinformatics\/btr064","article-title":"FIMO: Scanning for Occurrences of a given Motif","volume":"27","author":"Grant","year":"2011","journal-title":"Bioinformatics"},{"key":"ref_33","first-page":"526","article-title":"Associations between Functional Polymorphisms in the NF\u03baB Signaling Pathway and Response to Anti-TNF Treatment in Danish Patients with Inflammatory Bowel Disease","volume":"14","author":"Bank","year":"2014","journal-title":"Pharm. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/exd.14215","article-title":"Genome-wide Association Analysis of Psoriasis Patients Treated with Anti-TNF Drugs","volume":"29","author":"Sabador","year":"2020","journal-title":"Exp. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lauro, R., Mannino, F., Irrera, N., Squadrito, F., Altavilla, D., Squadrito, G., Pallio, G., and Bitto, A. (2021). Pharmacogenetics of Biological Agents Used in Inflammatory Bowel Disease: A Systematic Review. Biomedicines, 9.","DOI":"10.3390\/biomedicines9121748"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Caputo, V., Strafella, C., Cosio, T., Lanna, C., Campione, E., Novelli, G., Giardina, E., and Cascella, R. (2021). Pharmacogenomics: An Update on Biologics and Small-Molecule Drugs in the Treatment of Psoriasis. Genes, 12.","DOI":"10.3390\/genes12091398"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e14401","DOI":"10.1097\/MD.0000000000014401","article-title":"Association of Rs2910164 Polymorphism in MiR-146a Gene with Psoriasis Susceptibility: A Meta-Analysis","volume":"98","author":"Gong","year":"2019","journal-title":"Medicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/pcmedi\/pbz011","article-title":"Genetics of Psoriasis: A Basis for Precision Medicine","volume":"2","author":"Ran","year":"2019","journal-title":"Precis. Clin. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/ecco-jcc\/jjac033","article-title":"Characterisation of the Circulating Transcriptomic Landscape in Inflammatory Bowel Disease Provides Evidence for Dysregulation of Multiple Transcription Factors Including NFE2, SPI1, CEBPB, and IRF2","volume":"16","author":"Nowak","year":"2022","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1530\/EC-19-0446","article-title":"Gene Polymorphism and Plasma Levels of MiR-155 in Diabetic Retinopathy","volume":"8","author":"Polina","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42781","DOI":"10.18632\/oncotarget.5840","article-title":"A Functional Variant in MiR-155 Regulation Region Contributes to Lung Cancer Risk and Survival","volume":"6","author":"Xie","year":"2015","journal-title":"Oncotarget"},{"key":"ref_42","unstructured":"Ayoub, S.E., Shaker, O.G., Abdelwahed, M.Y., Ahmed, N.A., Abdelhameed, H.G., Bosilah, A.H., and Mohammed, S.R. (2019). Association of MicroRNA-155 Rs767649 Polymorphism with Susceptibility to Preeclampsia. Int. J. Mol. Cell. Med., 8."},{"key":"ref_43","first-page":"1425","article-title":"Impact of MiR-155 (Rs767649 A>T) and MiR-146a (Rs57095329 A>G) Polymorphisms in System Lupus Erythematosus Susceptibility in an Egyptian Cohort","volume":"25","author":"Mohammed","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11033-013-2953-0","article-title":"Association of the MiR-146aC>G, MiR-149T>C, and MiR-196a2T>C Polymorphisms with Gastric Cancer Risk and Survival in the Greek Population","volume":"41","author":"Dikeakos","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.advms.2019.12.005","article-title":"Impact of MiR-SNP Rs2910164 on MiR-146a Expression in Osteoarthritic Chondrocytes","volume":"65","author":"Papathanasiou","year":"2020","journal-title":"Adv. Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Han, Y.M., Koh, J., Kim, J.W., Lee, C., Koh, S.-J., Kim, B., Lee, K.L., Im, J.P., and Kim, J.S. (2017). NF-Kappa B Activation Correlates with Disease Phenotype in Crohn\u2019s Disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182071"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/2\/445\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:28:24Z","timestamp":1760120904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/2\/445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["genes14020445"],"URL":"https:\/\/doi.org\/10.3390\/genes14020445","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]}}}