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Shandong modern agricultural industry technology system","award":["319312101-03"],"award-info":[{"award-number":["319312101-03"]}]},{"name":"Donkey innovation team of Shandong modern agricultural industry technology system","award":["319312101-25"],"award-info":[{"award-number":["319312101-25"]}]},{"name":"Donkey innovation team of Shandong modern agricultural industry technology system","award":["319462207-21"],"award-info":[{"award-number":["319462207-21"]}]},{"name":"Rural Revitalization science and technology innovation promotion action plan project of Shandong","award":["SDAIT-27"],"award-info":[{"award-number":["SDAIT-27"]}]},{"name":"Rural Revitalization science and technology innovation promotion action plan project of Shandong","award":["2021TZXD012"],"award-info":[{"award-number":["2021TZXD012"]}]},{"name":"Rural Revitalization science and technology innovation promotion action plan project of 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University","award":["319312101-03"],"award-info":[{"award-number":["319312101-03"]}]},{"name":"Open Project of Animal Science of Liaocheng University","award":["319312101-25"],"award-info":[{"award-number":["319312101-25"]}]},{"name":"Open Project of Animal Science of Liaocheng University","award":["319462207-21"],"award-info":[{"award-number":["319462207-21"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["SDAIT-27"],"award-info":[{"award-number":["SDAIT-27"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["2021TZXD012"],"award-info":[{"award-number":["2021TZXD012"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["318052120"],"award-info":[{"award-number":["318052120"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["319312101-03"],"award-info":[{"award-number":["319312101-03"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["319312101-25"],"award-info":[{"award-number":["319312101-25"]}]},{"name":"Open Project of Liaocheng Universtiy Animal Husbandry Discipline","award":["319462207-21"],"award-info":[{"award-number":["319462207-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Colon cancer is one of the typical malignant tumors, and its prevalence has increased yearly. The ketogenic diet (KD) is a low-carbohydrate and high-fat dietary regimen that inhibits tumor growth. Donkey oil (DO) is a product with a high nutrient content and a high bioavailability of unsaturated fatty acids. Current research investigated the impact of the DO-based KD (DOKD) on CT26 colon cancer in vivo. Our findings revealed that DOKD administration significantly lowered CT26+ tumor cell growth in mice, and the blood \u03b2-hydroxybutyrate levels in the DOKD group was significantly higher than those in the natural diet group. Western blot results showed that DOKD significantly down-regulated Src, hypoxia inducible factor-1\u03b1 (HIF-1\u03b1), extracellular signal-related kinases 1 and 2 (Erk1\/2), snail, neural cadherin (N-cadherin), vimentin, matrix metallopeptidase 9 (MMP9), signal transducer and activator of transcription 3 (STAT3), and vascular endothelial growth factor A (VEGFA), and it significantly up-regulated the expressions of Sirt3, S100a9, interleukin (IL)-17, nuclear factor-kappaB (NF-\u03baB) p65, Toll-like receptor 4 (TLR4), MyD88, and tumor necrosis factor-\u03b1. Meanwhile, in vitro validation results showed that LW6 (a HIF-1\u03b1 inhibitor) significantly down-regulated the expressions of HIF-1\u03b1, N-cadherin, vimentin, MMP9, and VEGFA, which supported those of the in vivo findings. Furthermore, we found that DOKD inhibited CT26+ tumor cell growth by regulating inflammation, metastasis, and angiogenesis by activating the IL-17\/TLR4\/NF-\u03baB p65 pathway and inhibiting the activation of the Src\/HIF-1\u03b1\/Erk1\/2\/Snail\/N-cadherin\/Vimentin\/MMP9 and Erk1\/2\/HIF-1\u03b1\/STAT3\/VEGFA pathways. Our findings suggest that DOKD may suppress colon cancer progression and help prevent colon cancer cachexia.<\/jats:p>","DOI":"10.3390\/genes14051024","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T12:02:31Z","timestamp":1682942551000},"page":"1024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Donkey Oil-Based Ketogenic Diet Prevents Tumor Progression by Regulating Intratumor Inflammation, Metastasis and Angiogenesis in CT26 Tumor-Bearing Mice"],"prefix":"10.3390","volume":"14","author":[{"given":"Huachen","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-8611","authenticated-orcid":false,"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biopharmaceutical Research Institute, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhen","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Xing","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory of Equine Genetics, Breeding and Reproduction, Equine Research Center, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Faheem","family":"Akhtar","sequence":"additional","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanjie","family":"Li","sequence":"additional","affiliation":[{"name":"Office of International Programs, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiqin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Agronomy, Shandong Engineering Technology Research Center for Efficient Breeding and Ecological Feeding of Black Donkey, Shandong Donkey Industry Technology Collaborative Innovation Center, Liaocheng University, Liaocheng 252000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,30]]},"reference":[{"key":"ref_1","unstructured":"(2018). 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