{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:48:21Z","timestamp":1788850101006,"version":"build-2803163510"},"reference-count":198,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Topsector T&amp;U","award":["LWV20.105"],"award-info":[{"award-number":["LWV20.105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Plants evolved several mechanisms to protect themselves against viruses. Besides recessive resistance, where compatible host factors required for viral proliferation are absent or incompatible, there are (at least) two types of inducible antiviral immunity: RNA silencing (RNAi) and immune responses mounted upon activation of nucleotide-binding domain leucine-rich repeat (NLR) receptors. RNAi is associated with viral symptom recovery through translational repression and transcript degradation following recognition of viral double-stranded RNA produced during infection. NLR-mediated immunity is induced upon (in)direct recognition of a viral protein by an NLR receptor, triggering either a hypersensitive response (HR) or an extreme resistance response (ER). During ER, host cell death is not apparent, and it has been proposed that this resistance is mediated by a translational arrest (TA) of viral transcripts. Recent research indicates that translational repression plays a crucial role in plant antiviral resistance. This paper reviews current knowledge on viral translational repression during viral recovery and NLR-mediated immunity. Our findings are summarized in a model detailing the pathways and processes leading to translational arrest of plant viruses. This model can serve as a framework to formulate hypotheses on how TA halts viral replication, inspiring new leads for the development of antiviral resistance in crops.<\/jats:p>","DOI":"10.3390\/genes14061293","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T01:37:38Z","timestamp":1687225058000},"page":"1293","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Translation Arrest: A Key Player in Plant Antiviral Response"],"prefix":"10.3390","volume":"14","author":[{"given":"Annemarie","family":"Vermeulen","sequence":"first","affiliation":[{"name":"Molecular Plant Pathology, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2655-3108","authenticated-orcid":false,"given":"Frank L. W.","family":"Takken","sequence":"additional","affiliation":[{"name":"Molecular Plant Pathology, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-0301","authenticated-orcid":false,"given":"Victor A.","family":"S\u00e1nchez-Camargo","sequence":"additional","affiliation":[{"name":"Molecular Plant Pathology, Swammerdam Institute for Life Sciences (SILS), University of Amsterdam, 1098 XH Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.tree.2004.07.021","article-title":"Emerging Infectious Diseases of Plants: Pathogen Pollution, Climate Change and Agrotechnology Drivers","volume":"19","author":"Anderson","year":"2004","journal-title":"Trends Ecol. Evol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jee\/tov269","article-title":"Spray Toxicity and Risk Potential of 42 Commonly Used Formulations of Row Crop Pesticides to Adult Honey Bees (Hymenoptera: Apidae)","volume":"108","author":"Zhu","year":"2015","journal-title":"J. Econ. Entomol."},{"key":"ref_3","unstructured":"Granoff, A., and Webster, R.G. (2021). Encyclopedia of Virology, Academic Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-313X.2006.02792.x","article-title":"Mutations in the EIF(Iso)4G Translation Initiation Factor Confer High Resistance of Rice to Rice Yellow Mottle Virus","volume":"47","author":"Albar","year":"2006","journal-title":"Plant J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1094\/MPMI-23-1-0029","article-title":"Single Nucleotide Polymorphisms in a Gene for Translation Initiation Factor (EIF4G) of Rice (Oryza sativa) Associated with Resistance to Rice Tungro Spherical Virus","volume":"23","author":"Lee","year":"2009","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/mpp.12686","article-title":"Mutation of a Nicotiana tabacum L. Eukaryotic Translation-Initiation Factor Gene Reduces Susceptibility to a Resistance-Breaking Strain of Potato Virus Y","volume":"19","author":"Takakura","year":"2018","journal-title":"Mol. Plant Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev-phyto-102313-045854","article-title":"Susceptibility Genes 101: How to Be a Good Host","volume":"52","author":"Takken","year":"2014","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1387\/ijdb.210189kk","article-title":"RNA silencing pathway in plant development and defense","volume":"66","author":"Kryovrysanaki","year":"2022","journal-title":"Int. J. Dev. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1073\/pnas.1209487109","article-title":"Degradation of the Antiviral Component ARGONAUTE1 by the Autophagy Pathway","volume":"109","author":"Derrien","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1073\/pnas.0709036105","article-title":"Interaction with Host SGS3 Is Required for Suppression of RNA Silencing by Tomato Yellow Leaf Curl Virus V2 Protein","volume":"105","author":"Glick","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1094\/MPMI-02-13-0040-R","article-title":"Rice Yellow Stunt Rhabdovirus Protein 6 Suppresses Systemic RNA Silencing by Blocking RDR6-Mediated Secondary SiRNA Synthesis","volume":"26","author":"Guo","year":"2013","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/emboj.2008.129","article-title":"Nuclear Import of CaMV P6 Is Required for Infection and Suppression of the RNA Silencing Factor DRB4","volume":"27","author":"Haas","year":"2008","journal-title":"EMBO J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1038\/emboj.2012.92","article-title":"Differential Effects of Viral Silencing Suppressors on SiRNA and MiRNA Loading Support the Existence of Two Distinct Cellular Pools of ARGONAUTE1","volume":"31","author":"Schott","year":"2012","journal-title":"EMBO J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1038\/emboj.2010.215","article-title":"Plant Virus-Mediated Induction of MiR168 Is Associated with Repression of ARGONAUTE1 Accumulation","volume":"29","author":"Havelda","year":"2010","journal-title":"EMBO J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1128\/JVI.00727-07","article-title":"Modification of Small RNAs Associated with Suppression of RNA Silencing by Tobamovirus Replicase Protein","volume":"81","author":"Vogler","year":"2007","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.tplants.2022.07.003","article-title":"Resistance Genes on the Verge of Plant\u2013Virus Interaction","volume":"27","author":"Sett","year":"2022","journal-title":"Trends Plant Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.tplants.2009.08.001","article-title":"NB-LRRs Work a \u201cBait and Switch\u201d on Pathogens","volume":"14","author":"Collier","year":"2009","journal-title":"Trends Plant Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/nph.14877","article-title":"Multiple strategies for pathogen perception by plant immune receptors","volume":"219","author":"Cesari","year":"2017","journal-title":"New Phytol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.pbi.2006.05.009","article-title":"Resistance Proteins: Molecular Switches of Plant Defence","volume":"9","author":"Takken","year":"2006","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1105\/tpc.11.5.781","article-title":"The Rx Gene from Potato Controls Separate Virus Resistance and Cell Death Responses","volume":"11","author":"Bendahmane","year":"1999","journal-title":"Plant Cell"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1094\/MPMI-20-11-1396","article-title":"Tobacco Rattle Virus 29K Movement Protein Is the Elicitor of Extreme and Hypersensitive-like Resistance in Two Cultivars of Solanum tuberosum","volume":"20","author":"Ghazala","year":"2007","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/pbi.13230","article-title":"Extreme Resistance to Potato Virus Y in Potato Carrying the Rysto Gene Is Mediated by a TIR-NLR Immune Receptor","volume":"18","author":"Witek","year":"2020","journal-title":"Plant Biotechnol. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100086","DOI":"10.1016\/j.xplc.2020.100086","article-title":"A DNA-Binding Bromodomain-Containing Protein Interacts with and Reduces Rx1-Mediated Immune Response to Potato Virus X","volume":"1","author":"Sukarta","year":"2020","journal-title":"Plant Commun."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Alazem, M., Tseng, K.C., Chang, W.C., Seo, J.K., and Kim, K.H. (2018). Elements Involved in the Rsv3-Mediated Extreme Resistance against an Avirulent Strain of Soybean Mosaic Virus. Viruses, 10.","DOI":"10.3390\/v10110581"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/j.1365-313X.2009.03832.x","article-title":"Virus Resistance Induced by NB\u2013LRR Proteins Involves Argonaute4-Dependent Translational Control","volume":"58","author":"Bhattacharjee","year":"2009","journal-title":"Plant J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1094\/PHYTO-07-19-0229-FI","article-title":"HCPRO Suppression of Callose Deposition Contributes to Strain-Specific Resistance against Potato Virus Y","volume":"110","author":"Chowdhury","year":"2020","journal-title":"Phytopathology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-313x.2000.00658.x","article-title":"Movement of Plant Viruses Is Delayed in a \u03b2-1,3-Glucanase-Deficient Mutant Showing a Reduced Plasmodesmatal Size Exclusion Limit and Enhanced Callose Deposition","volume":"21","author":"Iglesias","year":"2000","journal-title":"Plant J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/tpj.15179","article-title":"Perturbation of Nuclear\u2013Cytosolic Shuttling of Rx1 Compromises Extreme Resistance and Translational Arrest of Potato Virus X Transcripts","volume":"106","author":"Richard","year":"2021","journal-title":"Plant J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"658981","DOI":"10.3389\/fpls.2021.658981","article-title":"Extreme Resistance to Viruses in Potato and Soybean","volume":"12","author":"Ross","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"srep05905","DOI":"10.1038\/srep05905","article-title":"Type 2C Protein Phosphatase Is a Key Regulator of Antiviral Extreme Resistance Limiting Virus Spread","volume":"4","author":"Seo","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1099\/0022-1317-67-11-2341","article-title":"Expression of Potato Virus X Resistance Gene Rx in Potato Leaf Protoplasts","volume":"67","author":"Adams","year":"1986","journal-title":"J. Gen. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1046\/j.1365-313X.1995.8060933.x","article-title":"The Coat Protein of Potato Virus X Is a Strain-Specific Elicitor of Rx1-Mediated Virus Resistance in Potato","volume":"8","author":"Bendahmane","year":"1995","journal-title":"Plant J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1105\/tpc.105.037234","article-title":"Elicitor-Mediated Oligomerization of the Tobacco N Disease Resistance Protein","volume":"18","author":"Mestre","year":"2006","journal-title":"Plant Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1105\/tpc.010366","article-title":"Short Defective Interfering RNAs of Tombusviruses Are Not Targeted but Trigger Post-Transcriptional Gene Silencing against Their Helper Virus","volume":"14","author":"Szittya","year":"2002","journal-title":"Plant Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/tpj.15248","article-title":"Global Analysis of Boron-Induced Ribosome Stalling Reveals Its Effects on Translation Termination and Unique Regulation by AUG-Stops in Arabidopsis Shoots","volume":"106","author":"Sotta","year":"2021","journal-title":"Plant J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1261\/rna.7258505","article-title":"Processing Bodies Require RNA for Assembly and Contain Nontranslating MRNAs","volume":"11","author":"Teixeira","year":"2005","journal-title":"RNA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41586-020-2231-y","article-title":"Plant 22-Nt SiRNAs Mediate Translational Repression and Stress Adaptation","volume":"581","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1126\/science.1159151","article-title":"Widespread Translational Inhibition by Plant MiRNAs and SiRNAs","volume":"320","author":"Brodersen","year":"2008","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1093\/jxb\/erw042","article-title":"NB-LRR Signaling Induces Translational Repression of Viral Transcripts and the Formation of RNA Processing Bodies through Mechanisms Differing from Those Activated by UV Stress and RNAi","volume":"67","author":"Meteignier","year":"2016","journal-title":"J. Exp. Bot."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/mpp.12816","article-title":"Virus Perception at the Cell Surface: Revisiting the Roles of Receptor-like Kinases as Viral Pattern Recognition Receptors","volume":"20","author":"Teixeira","year":"2019","journal-title":"Mol. Plant Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nature14171","article-title":"NIK1-Mediated Translation Suppression Functions as a Plant Antiviral Immunity Mechanism","volume":"520","author":"Zorzatto","year":"2015","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.virol.2015.01.008","article-title":"Symptom Recovery in Virus-Infected Plants: Revisiting the Role of RNA Silencing Mechanisms","volume":"479\u2013480","author":"Ghoshal","year":"2015","journal-title":"Virology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jxb\/eru447","article-title":"Different Roles for RNA Silencing and RNA Processing Components in Virus Recovery and Virus-Induced Gene Silencing in Plants","volume":"66","author":"Ma","year":"2015","journal-title":"J. Exp. Bot."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/1678-4685-gmb-2016-0092","article-title":"Translational Control in Plant Antiviral Immunity","volume":"40","author":"Machado","year":"2017","journal-title":"Genet. Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41580-021-00417-y","article-title":"Roles of MRNA Poly(A) Tails in Regulation of Eukaryotic Gene Expression","volume":"23","author":"Passmore","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Geng, G., Wang, D., Liu, Z., Wang, Y., Zhu, M., Cao, X., Yu, C., and Yuan, X. (2021). Translation of Plant RNA Viruses. Viruses, 13.","DOI":"10.3390\/v13122499"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"aad4939","DOI":"10.1126\/science.aad4939","article-title":"Comparative Genetics: Systematic Discovery of Cap-Independent Translation Sequences in Human and Viral Genomes","volume":"351","author":"Nir","year":"2016","journal-title":"Science"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1128\/jvi.62.8.2636-2643.1988","article-title":"A Segment of the 5\u2032 Nontranslated Region of Encephalomyocarditis Virus RNA Directs Internal Entry of Ribosomes during in Vitro Translation","volume":"62","author":"Jang","year":"1988","journal-title":"J. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1099\/vir.0.82307-0","article-title":"The RNA2 5\u2032 Leader of Blackcurrant Reversion Virus Mediates Effecient in Vivo Translation through an Internal Ribosomal Entry Site Mechanism","volume":"88","author":"Karetnikov","year":"2007","journal-title":"J. Gen. Virol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Roberts, R., Mayberry, L.K., Browning, K.S., and Rakotondrafara, A.M. (2017). The Triticum Mosaic Virus 5\u2032 Leader Binds to Both EIF4G and EIFiso4G for Translation. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0169602"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1074\/jbc.M703356200","article-title":"Potyvirus Genome-Linked Protein, VPg, Directly Affects Wheat Germ in Vitro Translation: Interactions with Translation Initiation Factors EIF4F and EIFiso4F","volume":"283","author":"Khan","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.biochi.2008.03.013","article-title":"Turnip Mosaic Virus VPg Interacts with Arabidopsis thaliana EIF(Iso)4E and Inhibits in Vitro Translation","volume":"90","author":"Miyoshi","year":"2008","journal-title":"Biochimie"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1128\/JVI.73.6.5172-5175.1999","article-title":"Alfalfa Mosaic Virus RNAs Serve as Cap Donors for Tomato Spotted Wilt Virus Transcription during Coinfection of Nicotiana benthamiana","volume":"73","author":"Duijsings","year":"1999","journal-title":"J. Virol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.1073\/pnas.95.14.8304","article-title":"In Vivo Transfer of Barley Stripe Mosaic Hordeivirus Ribonucleotides to the 5\u2032 Terminus of Maize Stripe Tenuivirus RNAs","volume":"95","author":"Estabrook","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virusres.2005.10.010","article-title":"Cap-Independent Translation of Plant Viral RNAs","volume":"119","author":"Kneller","year":"2006","journal-title":"Virus Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.2000.0421","article-title":"Synthesis of Subgenomic RNAs by Positive-Strand RNA Viruses","volume":"273","author":"Miller","year":"2000","journal-title":"Virology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/nar\/gkz783","article-title":"Translational Recoding: Canonical Translation Mechanisms Reinterpreted","volume":"48","author":"Rodnina","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"a032649","DOI":"10.1101\/cshperspect.a032649","article-title":"Translation Elongation and Recoding in Eukaryotes","volume":"10","author":"Dever","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.267.5195.229","article-title":"Inhibition of Host Gene Expression Associated with Plant Virus Replication","volume":"267","author":"Wang","year":"1995","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-virology-100114-055014","article-title":"A Cap-to-Tail Guide to MRNA Translation Strategies in Virus-Infected Cells","volume":"3","author":"Jan","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"ref_61","unstructured":"Bamford, D.A., and Zuckerman, M. (2021). Encyclopedia of Virology, Academic Press."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/mpp.12422","article-title":"Analysis of the Interacting Partners EIF4F and 3\u2032-CITE Required for Melon Necrotic Spot Virus Cap-Independent Translation","volume":"18","author":"Miras","year":"2017","journal-title":"Mol. Plant Pathol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1261\/rna.2135210","article-title":"Tombusvirus Recruitment of Host Translational Machinery via the 3\u2032 UTR","volume":"16","author":"Nicholson","year":"2010","journal-title":"RNA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1074\/jbc.M114.602649","article-title":"Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating EIF4E Activity during Infection","volume":"290","author":"Royall","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/jb\/mvy091","article-title":"Phosphorylation of Translation Initiation Factor EIFiso4E Promotes Translation through Enhanced Binding to Potyvirus VPg","volume":"165","author":"Khan","year":"2019","journal-title":"J. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Khan, M.A., Kumar, P., Akif, M., and Miyoshi, H. (2021). Phosphorylation of Eukaryotic Initiation Factor EIFiso4E Enhances the Binding Rates to VPg of Turnip Mosaic Virus. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0259688"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1099\/0022-1317-20-1-37","article-title":"Fine Structure of Vesicles Induced in Chloroplasts of Chinese Cabbage Leaves by Infection with Turnip Yellow Mosaic Virus","volume":"20","author":"Hatta","year":"1973","journal-title":"J. Gen. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1099\/0022-1317-35-3-535","article-title":"An Ultrastructural Study of Inclusions and Disease Development in Plant Cells Infected by Cowpea Chlorotic Mottle Virus","volume":"35","author":"Kim","year":"1977","journal-title":"J. Gen. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1105\/tpc.105.036350","article-title":"Localization of the Tomato Bushy Stunt Virus Replication Protein P33 Reveals a Peroxisome-to-Endoplasmic Reticulum Sorting Pathway","volume":"17","author":"McCartney","year":"2005","journal-title":"Plant Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.virol.2009.05.012","article-title":"Induction of Necrosis via Mitochondrial Targeting of Melon Necrotic Spot Virus Replication Protein P29 by Its Second Transmembrane Domain","volume":"390","author":"Mochizuki","year":"2009","journal-title":"Virology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1093\/emboj\/16.13.4049","article-title":"Formation of Plant RNA Virus Replication Complexes on Membranes: Role of an Endoplasmic Reticulum-Targeted Viral Protein","volume":"16","author":"Schaad","year":"1997","journal-title":"EMBO J."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Amari, K., Lerich, A., Schmitt-Keichinger, C., Dolja, V.V., and Ritzenthaler, C. (2011). Tubule-Guided Cell-to-Cell Movement of a Plant Virus Requires Class XI Myosin Motors. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1002327"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2007.08.005","article-title":"Colocalization of Transcription and Translation within Cytoplasmic Poxvirus Factories Coordinates Viral Expression and Subjugates Host Functions","volume":"2","author":"Katsafanas","year":"2007","journal-title":"Cell Host Microbe"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1128\/JVI.79.12.7812-7818.2005","article-title":"Plant Virus-Derived Small Interfering RNAs Originate Predominantly from Highly Structured Single-Stranded Viral RNAs","volume":"79","author":"Csorba","year":"2005","journal-title":"J. Virol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.micro.60.080805.142205","article-title":"Virus Counterdefense: Diverse Strategies for Evading the RNA-Silencing Immunity","volume":"60","author":"Li","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.coviro.2011.10.028","article-title":"Virus-Derived SiRNAs and PiRNAs in Immunity and Pathogenesis","volume":"1","author":"Ding","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"ref_77","first-page":"277","article-title":"Dicer-like (DCL) Proteins in Plants. Funct. Integr","volume":"9","author":"Liu","year":"2009","journal-title":"Genomics"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1128214","article-title":"Hierarchical Action and Inhibition of Plant Dicer-like Proteins in Antiviral Defense","volume":"313","author":"Deleris","year":"2006","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/mpp.13250","article-title":"The Master Role of SiRNAs in Plant Immunity","volume":"23","author":"Kong","year":"2022","journal-title":"Mol. Plant Pathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pbi.2015.06.013","article-title":"Antiviral Roles of Plant ARGONAUTES","volume":"27","author":"Carbonell","year":"2015","journal-title":"Curr. Opin. Plant Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1101\/gad.1495506","article-title":"Cucumber Mosaic Virus-Encoded 2b Suppressor Inhibits Arabidopsis Argonaute1 Cleavage Activity to Counter Plant Defense","volume":"20","author":"Zhang","year":"2006","journal-title":"Genes Dev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1104\/pp.105.066563","article-title":"Effect of Temperature on Geminivirus-Induced RNA Silencing in Plants","volume":"138","author":"Chellappan","year":"2005","journal-title":"Plant Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/385781a0","article-title":"Plants Combat Infection by Gene Silencing","volume":"385","author":"Covey","year":"1997","journal-title":"Nature"},{"key":"ref_84","first-page":"127","article-title":"Hosts and Symptoms of Ring Spot, A Virus Disease of Plants","volume":"37","author":"Wingard","year":"1928","journal-title":"J. Agric. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.virol.2003.08.009","article-title":"Identification and Molecular Characterization of a Naturally Occurring RNA Virus Mutant Defective in the Initiation of Host Recovery","volume":"317","author":"Xin","year":"2003","journal-title":"Virology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"12285","DOI":"10.1128\/JVI.01192-07","article-title":"Recovery of Nicotiana benthamiana Plants from a Necrotic Response Induced by a Nepovirus Is Associated with RNA Silencing but Not with Reduced Virus Titer","volume":"81","author":"Jovel","year":"2007","journal-title":"J. Virol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1094\/MPMI-04-14-0099-R","article-title":"Tomato Ringspot Virus Coat Protein Binds to ARGONAUTE 1 and Suppresses the Translation Repression of a Reporter Gene","volume":"27","author":"Karran","year":"2014","journal-title":"Mol. Plant-Microbe Interact."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1105\/tpc.11.7.1207","article-title":"Gene Silencing without DNA: RNA-Mediated Cross-Protection between Viruses","volume":"11","author":"Ratcliff","year":"1999","journal-title":"Plant Cell"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.virol.2010.12.018","article-title":"An Antiviral RISC Isolated from Tobacco Rattle Virus-Infected Plants","volume":"412","author":"Ciomperlik","year":"2011","journal-title":"Virology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41477-018-0117-x","article-title":"Crosstalk between PTGS and TGS Pathways in Natural Antiviral Immunity and Disease Recovery","volume":"4","author":"Pitzalis","year":"2018","journal-title":"Nat. Plants"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2307\/3869659","article-title":"A Potato Virus X Resistance Gene Mediates an Induced, Nonspecific Resistance in Protoplasts","volume":"5","author":"Kohm","year":"1993","journal-title":"Plant Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00260710","article-title":"RFLP Mapping on Potato Chromosomes of Two Genes Controlling Extreme Resistance to Potato Virus X (PVX)","volume":"227","author":"Ritter","year":"1991","journal-title":"Mol. Gen. Genet."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"24945","DOI":"10.1074\/jbc.M115.672121","article-title":"The Potato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-Dependent DNA-Deforming Protein","volume":"290","author":"Fenyk","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2307\/3869660","article-title":"Functionally Homologous Host Components Recognize Potato Virus X in Gomphrena globosa and Potato","volume":"5","author":"Goulden","year":"1993","journal-title":"Plant Cell"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/mpp.12776","article-title":"Activation of Immune Receptor Rx1 Triggers Distinct Immune Responses Culminating in Cell Death after 4 Hours","volume":"20","author":"Knip","year":"2019","journal-title":"Mol. Plant Pathol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1105\/tpc.110.077537","article-title":"Nucleocytoplasmic Distribution Is Required for Activation of Resistance by the Potato NB-LRR Receptor Rx1 and Is Balanced by Its Functional Domains","volume":"22","author":"Slootweg","year":"2012","journal-title":"Plant Cell"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Sukarta, O.C.A., Diaz-Granados, A., Slootweg, E.J., Overmars, H., van Schaik, C., Pokhare, S., Roosien, J., Pomp, R., Elashry, A., and Smant, G. (2021). Two Evolutionary Distinct Effectors from a Nematode and Virus Target RanGAP1 and 2 via the WPP Domain to Promote Disease. bioRxiv.","DOI":"10.1101\/2021.06.24.449730"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"35868","DOI":"10.1074\/jbc.M113.517417","article-title":"Structural Basis for the Interaction between the Potato Virus X Resistance Protein (Rx) and Its Cofactor Ran GTPase-Activating Protein 2 (RanGAP2)","volume":"288","author":"Hao","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1365-313X.2007.03213.x","article-title":"A RanGAP Protein Physically Interacts with the NB-LRR Protein Rx, and Is Required for Rx-Mediated Viral Resistance","volume":"52","author":"Sacco","year":"2007","journal-title":"Plant J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1105\/tpc.107.050880","article-title":"Physical Association of the NB-LRR Resistance Protein Rx with a Ran GTPase\u2013Activating Protein Is Required for Extreme Resistance to Potato Virus X","volume":"19","author":"Tameling","year":"2007","journal-title":"Plant Cell"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1074\/jbc.RA117.000485","article-title":"The Intracellular Immune Receptor Rx1 Regulates the DNA-Binding Activity of a Golden2-like Transcription Factor","volume":"293","author":"Townsend","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0092-8674(94)90283-6","article-title":"The Product of the Tobacco Mosaic Virus Resistance Gene N: Similarity to Toll and the Interleukin-1 Receptor","volume":"78","author":"Whitham","year":"1994","journal-title":"Cell"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-313X.1999.00426.x","article-title":"The Helicase Domain of the TMV Replicase Proteins Induces the N-Mediated Defence Response in Tobacco","volume":"18","author":"Erickson","year":"1999","journal-title":"Plant J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2007.12.031","article-title":"Chloroplastic Protein NRIP1 Mediates Innate Immune Receptor Recognition of a Viral Effector","volume":"132","author":"Caplan","year":"2008","journal-title":"Cell"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Burch-Smith, T.M., Schiff, M., Caplan, J.L., Tsao, J., Czymmek, K., and Dinesh-Kumar, S.P. (2007). A Novel Role for the TIR Domain in Association with Pathogen-Derived Elicitors. PLoS Biol., 5.","DOI":"10.1371\/journal.pbio.0050068"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Sakamoto, T., Deguchi, M., Brustolini, O.J.B., Santos, A.A., Silva, F.F., and Fontes, E.P.B. (2012). The Tomato RLK Superfamily: Phylogeny and Functional Predictions about the Role of the LRRII-RLK Subfamily in Antiviral Defense. BMC Plant Biol., 12.","DOI":"10.1186\/1471-2229-12-229"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.chom.2008.05.017","article-title":"Bacterial Effectors Target the Common Signaling Partner BAK1 to Disrupt Multiple MAMP Receptor-Signaling Complexes and Impede Plant Immunity","volume":"4","author":"Shan","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.1073\/pnas.181141598","article-title":"Receptor-like Kinases from Arabidopsis Form a Monophyletic Gene Family Related to Animal Receptor Kinases","volume":"98","author":"Shiu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Carvalho, C.M., Santos, A.A., Pires, S.R., Rocha, C.S., Saraiva, D.I., Machado, J.P.B., Mattos, E.C., Fietto, L.G., and Fontes, E.P.B. (2008). Regulated Nuclear Trafficking of RpL10A Mediated by NIK1 Represents a Defense Strategy of Plant Cells against Virus. PLoS Pathog., 4.","DOI":"10.1371\/journal.ppat.1000247"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/sj.emboj.7601073","article-title":"Antiviral Effect of the Mammalian Translation Initiation Factor 2\u03b1 Kinase GCN2 against RNA Viruses","volume":"25","author":"Berlanga","year":"2006","journal-title":"EMBO J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jmb.2009.05.005","article-title":"RNA Dimerization Promotes PKR Dimerization and Activation","volume":"390","author":"Heinicke","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1126\/science.1147347","article-title":"5\u2032-Triphosphate-Dependent Activation of PKR by RNAs with Short Stem-Loops","volume":"318","author":"Nallagatla","year":"2007","journal-title":"Science"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jmb.2010.04.059","article-title":"Regulation of PKR by HCV IRES RNA: Importance of Domain II and NS5A","volume":"400","author":"Toroney","year":"2010","journal-title":"J. Mol. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/JVI.74.3.1085-1093.2000","article-title":"Cap-Independent Translational Enhancement of Turnip Crinkle Virus Genomic and Subgenomic RNAs","volume":"74","author":"Qu","year":"2000","journal-title":"J. Virol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.molcel.2013.10.033","article-title":"Molecular Insights into MicroRNA-Mediated Translational Repression in Plants","volume":"52","author":"Iwakawa","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1105\/tpc.108.063412","article-title":"Biochemical Evidence for Translational Repression by Arabidopsis MicroRNAs","volume":"21","author":"Lanet","year":"2009","journal-title":"Plant Cell"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/d41586-018-03070-2","article-title":"What Lava Lamps and Vinaigrette Can Teach Us about Cell Biology","volume":"555","author":"Dolgin","year":"2018","journal-title":"Nature"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-cellbio-100913-013325","article-title":"Liquid-Liquid Phase Separation in Biology","volume":"30","author":"Hyman","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.molcel.2009.11.020","article-title":"Eukaryotic Stress Granules: The Ins and Outs of Translation","volume":"36","author":"Buchan","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1094\/MPMI-06-19-0161-FI","article-title":"Cellular RNA Hubs: Friends and Foes of Plant Viruses","volume":"33","author":"Xu","year":"2020","journal-title":"Mol. Plant. Microbe Interact."},{"key":"ref_121","first-page":"201","article-title":"Composition and Function of P Bodies in Arabidopsis thaliana","volume":"5","year":"2014","journal-title":"Front. Plant Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1126\/science.1172046","article-title":"Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution\/Condensation","volume":"324","author":"Brangwynne","year":"2009","journal-title":"Science"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.celrep.2018.05.041","article-title":"Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery","volume":"23","author":"Kroschwald","year":"2018","journal-title":"Cell Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1128\/MCB.00128-07","article-title":"P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing","volume":"27","author":"Eulalio","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-313X.2008.03623.x","article-title":"Plant Stress Granules and MRNA Processing Bodies Are Distinct from Heat Stress Granules","volume":"56","author":"Weber","year":"2008","journal-title":"Plant J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1105\/tpc.106.047605","article-title":"Arabidopsis DCP2, DCP1, and VARICOSE Form a Decapping Complex Required for Postembryonic Development","volume":"18","author":"Xu","year":"2006","journal-title":"Plant Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1082320","article-title":"Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies","volume":"300","author":"Sheth","year":"2003","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"9759","DOI":"10.1128\/JVI.00844-07","article-title":"Interactions between Brome Mosaic Virus RNAs and Cytoplasmic Processing Bodies","volume":"81","author":"Beckham","year":"2007","journal-title":"J. Virol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1261\/rna.1712910","article-title":"LSm1-7 Complexes Bind to Specific Sites in Viral RNA Genomes and Regulate Their Translation and Replication","volume":"16","author":"Chari","year":"2010","journal-title":"RNA"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/pcp\/pcu151","article-title":"Diffuse Decapping Enzyme DCP2 Accumulates in DCP1 Foci Under Heat Stress in Arabidopsis thaliana","volume":"56","author":"Motomura","year":"2015","journal-title":"Plant Cell Physiol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Lageix, S., Lanet, E., Pouch-P\u00e9lissier, M.N., Espagnol, M.C., Robaglia, C., Deragon, J.M., and P\u00e9lissier, T. (2008). Arabidopsis EIF2\u03b1 Kinase GCN2 Is Essential for Growth in Stress Conditions and Is Activated by Wounding. BMC Plant Biol., 8.","DOI":"10.1186\/1471-2229-8-134"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Harvey, J.J.W., Lewsey, M.G., Patel, K., Westwood, J., Heimst\u00e4dt, S., Carr, J.P., and Baulcombe, D.C. (2011). An Antiviral Defense Role of AGO2 in Plants. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0014639"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1104\/pp.111.178012","article-title":"ARGONAUTE2 Mediates RNA-Silencing Antiviral Defenses against Potato Virus X in Arabidopsis","volume":"156","author":"Jaubert","year":"2011","journal-title":"Plant Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1105\/tpc.010358","article-title":"Fertile Hypomorphic ARGONAUTE (Ago1) Mutants Impaired in Post-Transcriptional Gene Silencing and Virus Resistance","volume":"14","author":"Morel","year":"2002","journal-title":"Plant Cell"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1104\/pp.111.178764","article-title":"Identification of an ARGONAUTE for Antiviral RNA Silencing in Nicotiana benthamiana","volume":"156","author":"Scholthof","year":"2011","journal-title":"Plant Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"14732","DOI":"10.1073\/pnas.0805760105","article-title":"Arabidopsis DRB4, AGO1, AGO7, and RDR6 Participate in a DCL4-Initiated Antiviral RNA Silencing Pathway Negatively Regulated by DCL1","volume":"105","author":"Qu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"11928","DOI":"10.1073\/pnas.0505461102","article-title":"Arabidopsis ARGONAUTE1 Is an RNA Slicer That Selectively Recruits MicroRNAs and Short Interfering RNAs","volume":"102","author":"Baumberger","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1073\/pnas.1114673109","article-title":"Mutations in the GW-Repeat Protein SUO Reveal a Developmental Function for MicroRNA-Mediated Translational Repression in Arabidopsis","volume":"109","author":"Yang","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1126\/science.1102514","article-title":"Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity","volume":"305","author":"Song","year":"2004","journal-title":"Science"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.molcel.2011.09.007","article-title":"GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to MiRNA Targets","volume":"44","author":"Braun","year":"2011","journal-title":"Mol. Cell"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1093\/nar\/gkq162","article-title":"Genome-Wide Computational Identification of WG\/GW Argonaute-Binding Proteins in Arabidopsis","volume":"38","author":"Karlowski","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrm2885","article-title":"Role of GW182 Proteins and PABPC1 in the MiRNA Pathway: A Sense of D\u00e9j\u00e0 Vu","volume":"11","author":"Tritschler","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1105\/tpc.112.105643","article-title":"Lessons on RNA Silencing Mechanisms in Plants from Eukaryotic Argonaute Structures","volume":"25","author":"Poulsen","year":"2013","journal-title":"Plant Cell"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1101\/gad.1908710","article-title":"Argonaute Quenching and Global Changes in Dicer Homeostasis Caused by a Pathogen-Encoded GW Repeat Protein","volume":"24","author":"Azevedo","year":"2010","journal-title":"Genes Dev."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1128\/JVI.00497-12","article-title":"Temperature-Dependent Survival of Turnip Crinkle Virus-Infected Arabidopsis Plants Relies on an RNA Silencing-Based Defense That Requires DCL2, AGO2, and HEN1","volume":"86","author":"Zhang","year":"2012","journal-title":"J. Virol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.cub.2007.08.039","article-title":"The Polerovirus Silencing Suppressor P0 Targets ARGONAUTE Proteins for Degradation","volume":"17","author":"Baumberger","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1261\/rna.060434.116","article-title":"Biochemical and Genetic Functional Dissection of the P38 Viral Suppressor of RNA Silencing","volume":"23","author":"Iki","year":"2017","journal-title":"RNA"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0042-6822(02)00018-1","article-title":"Turnip Crinkle Virus Coat Protein Mediates Suppression of RNA Silencing in Nicotiana benthamiana","volume":"306","author":"Thomas","year":"2003","journal-title":"Virology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1099\/vir.0.83621-0","article-title":"Effects of Viral Silencing Suppressors on Tobacco Ringspot Virus Infection in Two Nicotiana Species","volume":"89","author":"Siddiqui","year":"2008","journal-title":"J. Gen. Virol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/viro.1999.0071","article-title":"Genetic Dissection of Tomato Bushy Stunt Virus P19-Protein-Mediated Host-Dependent Symptom Induction and Systemic Invasion","volume":"266","author":"Chu","year":"2000","journal-title":"Virology"},{"key":"ref_151","first-page":"642","article-title":"The Role of the Cucumber Mosaic Virus 2b Protein in Viral Movement and Symptom Induction","volume":"22","author":"Lewsey","year":"2009","journal-title":"Mol. Plant Pathol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1094\/PHYTO-97-3-0287","article-title":"Modifications of the Helper Component-Protease of Zucchini Yellow Mosaic Virus for Generation of Attenuated Mutants for Cross Protection Against Severe Infection","volume":"97","author":"Lin","year":"2007","journal-title":"Phytopathology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chom.2010.06.009","article-title":"Viral Suppressors of RNA-Based Viral Immunity: Host Targets","volume":"8","author":"Wu","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1099\/jgv.0.000323","article-title":"Tobacco Rattle Virus 16K Silencing Suppressor Binds ARGONAUTE 4 and Inhibits Formation of RNA Silencing Complexes","volume":"97","author":"Szabo","year":"2016","journal-title":"J. Gen. Virol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1095989","article-title":"RNA Silencing Genes Control de Novo DNA Methylation","volume":"303","author":"Chan","year":"2004","journal-title":"Science"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1126\/science.1079695","article-title":"ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation","volume":"299","author":"Zilberman","year":"2003","journal-title":"Science"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1094\/MPMI-09-16-0188-R","article-title":"Antiviral Defense Involves AGO4 in an Arabidopsis-Potexvirus Interaction","volume":"29","author":"Brosseau","year":"2016","journal-title":"Mol. Plant. Microbe Interact."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1093\/emboj\/cdf312","article-title":"A Viral Protein Suppresses RNA Silencing and Binds Silencing-Generated, 21- to 25-Nucleotide Double-Stranded RNAs","volume":"21","author":"Silhavy","year":"2002","journal-title":"EMBO J."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1105\/tpc.106.047621","article-title":"Components of the Arabidopsis MRNA Decapping Complex Are Required for Early Seedling Development","volume":"19","author":"Goeres","year":"2007","journal-title":"Plant Cell"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/tpj.14022","article-title":"The UPF1 Interactome Reveals Interaction Networks between RNA Degradation and Translation Repression Factors in Arabidopsis","volume":"96","author":"Chicois","year":"2018","journal-title":"Plant J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1105\/tpc.109.070078","article-title":"Arabidopsis Decapping 5 Is Required for MRNA Decapping, P-Body Formation, and Translational Repression during Postembryonic Development","volume":"21","author":"Xu","year":"2009","journal-title":"Plant Cell"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Bogamuwa, S., and Jang, J.-C. (2016). Plant Tandem CCCH Zinc Finger Proteins Interact with ABA, Drought, and Stress Response Regulators in Processing-Bodies and Stress Granules. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0151574"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1104\/pp.109.145656","article-title":"The Arabidopsis Tandem Zinc Finger Protein AtTZF1 Traffics between the Nucleus and Cytoplasmic Foci and Binds Both DNA and RNA","volume":"152","author":"Pomeranz","year":"2009","journal-title":"Plant Physiol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/tpj.12485","article-title":"The Arabidopsis thaliana Tandem Zinc Finger 1 (AtTZF1) Protein in RNA Binding and Decay","volume":"78","author":"Qu","year":"2014","journal-title":"Plant J."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1016\/j.jmb.2018.06.014","article-title":"RGG\/RG Motif Regions in RNA Binding and Phase Separation","volume":"430","author":"Chong","year":"2018","journal-title":"J. Mol. Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.200704147","article-title":"Edc3p and a Glutamine\/Asparagine-Rich Domain of Lsm4p Function in Processing Body Assembly in Saccharomyces Cerevisiae","volume":"179","author":"Decker","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"7189","DOI":"10.1073\/pnas.1504822112","article-title":"The Disordered P Granule Protein LAF-1 Drives Phase Separation into Droplets with Tunable Viscosity and Dynamics","volume":"112","author":"Kim","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"722643","DOI":"10.3389\/fpls.2021.722643","article-title":"Plant Stress Granules: Trends and Beyond","volume":"12","author":"Figueroa","year":"2021","journal-title":"Front. Plant Sci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2017.12.032","article-title":"Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules","volume":"172","author":"Markmiller","year":"2018","journal-title":"Cell"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cell.2020.03.046","article-title":"G3BP1 Is a Tunable Switch That Triggers Phase Separation to Assemble Stress Granules","volume":"181","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.molcel.2017.12.020","article-title":"High-Density Proximity Mapping Reveals the Subcellular Organization of MRNA-Associated Granules and Bodies","volume":"69","author":"Youn","year":"2018","journal-title":"Mol. Cell"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1105\/tpc.002493","article-title":"Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene\u2013Mediated Resistance Response to Tobacco Mosaic Virus","volume":"14","author":"Liu","year":"2002","journal-title":"Plant Cell"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1365-313X.2004.02085.x","article-title":"Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY\/MYB Transcription Factors, COI1 and CTR1 in N-Mediated Resistance to Tobacco Mosaic Virus","volume":"38","author":"Liu","year":"2004","journal-title":"Plant J."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Padmanabhan, M.S., Ma, S., Burch-Smith, T.M., Czymmek, K., Huijser, P., and Dinesh-Kumar, S.P. (2013). Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003235"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1261\/rna.7131604","article-title":"Tethering of Human Ago Proteins to mRNA Mimics the MiRNA-Mediated Repression of Protein Synthesis","volume":"10","author":"Pillai","year":"2004","journal-title":"RNA"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Nielsen, C.P.S., Han, L., Arribas-Hern\u00e1ndez, L., Karelina, D., Petersen, M., and Brodersen, P. (2023). Sensing of Viral RNA in Plants via a DICER-LIKE Ribonuclease. bioRxiv.","DOI":"10.1101\/2023.01.10.523395"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1104\/pp.109.138990","article-title":"The Role of WRKY Transcription Factors in Plant Immunity","volume":"150","author":"Pandey","year":"2009","journal-title":"Plant Physiol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature13590","article-title":"Antiviral Immunity via RIG-I-Mediated Recognition of RNA Bearing 5\u2032-Diphosphates","volume":"514","author":"Goubau","year":"2014","journal-title":"Nature"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/s41556-019-0416-0","article-title":"Mitochondria-Localised ZNFX1 Functions as a DsRNA Sensor to Initiate Antiviral Responses through MAVS","volume":"21","author":"Wang","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/cmi.2013.40","article-title":"The Interaction between the Helicase DHX33 and IPS-1 as a Novel Pathway to Sense Double-Stranded RNA and RNA Viruses in Myeloid Dendritic Cells. Cell","volume":"11","author":"Liu","year":"2013","journal-title":"Mol. Immunol"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Oshiumi, H., Ikeda, M., Matsumoto, M., Watanabe, A., Takeuchi, O., Akira, S., Kato, N., Shimotohno, K., and Seya, T. (2010). Hepatitis C Virus Core Protein Abrogates the DDX3 Function That Enhances IPS-1-Mediated IFN\u2013\u03b2 Induction. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014258"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1128\/JVI.03213-12","article-title":"van MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon","volume":"87","author":"Langereis","year":"2013","journal-title":"J. Virol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Onomoto, K., Jogi, M., Yoo, J.S., Narita, R., Morimoto, S., Takemura, A., Sambhara, S., Kawaguchi, A., Osari, S., and Nagata, K. (2012). Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity. PLoS ONE, 7.","DOI":"10.1371\/annotation\/dcd836ee-9e23-4538-acb7-450560ba5c1d"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1104\/pp.18.00603","article-title":"Distinct Roles of Non-Overlapping Surface Regions of the Coiled-Coil Domain in the Potato Immune Receptor Rx1","volume":"178","author":"Slootweg","year":"2018","journal-title":"Plant Physiol."},{"key":"ref_186","first-page":"411","article-title":"Interaction of 2\u2032,3\u2032-CAMP with Rbp47b Plays a Role in Stress Granule Formation","volume":"177","author":"Kosmacz","year":"2018","journal-title":"Plant Physiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.cell.2022.04.032","article-title":"TIR Domains of Plant Immune Receptors Are 2\u2032,3\u2032-CAMP\/CGMP Synthetases Mediating Cell Death","volume":"185","author":"Yu","year":"2022","journal-title":"Cell"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e49551","DOI":"10.7554\/eLife.49551","article-title":"Ribosome Biogenesis Restricts Innate Immune Responses to Virus Infection and DNA","volume":"8","author":"Bianco","year":"2019","journal-title":"eLife"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1128\/MCB.00879-12","article-title":"Ribosomal Protein S25 Dependency Reveals a Common Mechanism for Diverse Internal Ribosome Entry Sites and Ribosome Shunting","volume":"33","author":"Hertz","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Huang, J.Y., Su, W.C., Jeng, K.S., Chang, T.H., and Lai, M.M.C. (2012). Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002766"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1073\/pnas.1216454109","article-title":"A Ribosome-Specialized Translation Initiation Pathway Is Required for Cap-Dependent Translation of Vesicular Stomatitis Virus MRNAs","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.virol.2009.05.018","article-title":"Differential Requirement of Ribosomal Protein S6 by Plant RNA Viruses with Different Translation Initiation Strategies","volume":"390","author":"Yang","year":"2009","journal-title":"Virology"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1111\/febs.14935","article-title":"Phosphorylation of Arabidopsis EIF4E and EIFiso4E by SnRK1 Inhibits Translation","volume":"286","author":"Bruns","year":"2019","journal-title":"FEBS J."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fpls.2020.00016","article-title":"The Importance of TOR Kinase in Plant Development","volume":"11","author":"McCready","year":"2020","journal-title":"Front. Plant Sci."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Soto-Burgos, J., and Bassham, D.C. (2017). SnRK1 Activates Autophagy via the TOR Signaling Pathway in Arabidopsis thaliana. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0182591"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"e1414120","DOI":"10.1080\/15592324.2017.1414120","article-title":"TOR Signaling Downregulation Increases Resistance to the Cereal Killer Fusarium Graminearum","volume":"13","author":"Aznar","year":"2018","journal-title":"Plant Signal. Behav."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1099\/vir.0.000186","article-title":"Potyviruses Differ in Their Requirement for TOR Signalling","volume":"96","author":"Ouibrahim","year":"2015","journal-title":"J. Gen. Virol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/mpp.13207","article-title":"TOR Inhibition Primes Immunity and Pathogen Resistance in Tomato in a Salicylic Acid-Dependent Manner","volume":"23","author":"Marash","year":"2022","journal-title":"Mol. Plant Pathol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/6\/1293\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:56:40Z","timestamp":1760126200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/6\/1293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,19]]},"references-count":198,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["genes14061293"],"URL":"https:\/\/doi.org\/10.3390\/genes14061293","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,19]]}}}