{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:59:13Z","timestamp":1791838753061,"version":"4.3.4"},"reference-count":83,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["MOST-110-2628-B-037-007"],"award-info":[{"award-number":["MOST-110-2628-B-037-007"]}]},{"name":"Taiwan National Science and Technology Council","award":["NSTC-111-2314-B-037-042"],"award-info":[{"award-number":["NSTC-111-2314-B-037-042"]}]},{"name":"Taiwan National Science and Technology Council","award":["KMUH110-0R61"],"award-info":[{"award-number":["KMUH110-0R61"]}]},{"name":"Taiwan National Science and Technology Council","award":["KMUH111-1R59"],"award-info":[{"award-number":["KMUH111-1R59"]}]},{"name":"Kaohsiung Medical University Hospital","award":["MOST-110-2628-B-037-007"],"award-info":[{"award-number":["MOST-110-2628-B-037-007"]}]},{"name":"Kaohsiung Medical University Hospital","award":["NSTC-111-2314-B-037-042"],"award-info":[{"award-number":["NSTC-111-2314-B-037-042"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH110-0R61"],"award-info":[{"award-number":["KMUH110-0R61"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH111-1R59"],"award-info":[{"award-number":["KMUH111-1R59"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease characterized by the appearance of clearly demarcated erythematous and scaly plaques. It can be divided into various types, including plaque, nail, guttate, inverse, and pustular psoriasis. Plaque psoriasis is the most commonly occurring type, though there is another rare but severe pustular autoinflammatory skin disease called generalized pustular psoriasis (GPP), which manifests with acute episodes of pustulation and systemic symptoms. Though the etiopathogenesis of psoriasis is not yet fully understood, a growing body of literature has demonstrated that both genetic and environmental factors play a role. The discovery of genetic mutations associated with GPP has shed light on our comprehension of the mechanisms of the disease, promoting the development of targeted therapies. This review will summarize genetic determinants as known and provide an update on the current and potential treatments for GPP. The pathogenesis and clinical presentation of the disease are also included for a comprehensive discussion.<\/jats:p>","DOI":"10.3390\/genes14061297","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T01:35:11Z","timestamp":1687311311000},"page":"1297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Genetics of Generalized Pustular Psoriasis: Current Understanding and Implications for Future Therapeutics"],"prefix":"10.3390","volume":"14","author":[{"given":"Syuan-Fei","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Huei","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Chen","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Kai","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Yi","family":"Shih","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Su","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-458X","authenticated-orcid":false,"given":"Sebastian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"},{"name":"Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/jdv.14386","article-title":"European consensus statement on phenotypes of pustular psoriasis","volume":"31","author":"Navarini","year":"2017","journal-title":"J. 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