{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:41:24Z","timestamp":1760128884441,"version":"build-2065373602"},"reference-count":18,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Academy of Science","award":["FURG-2023-009"],"award-info":[{"award-number":["FURG-2023-009"]}]},{"name":"Sechenov University Innovative Scientific School","award":["FURG-2023-009"],"award-info":[{"award-number":["FURG-2023-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>A 60-year-old male with hypertrophic cardiomyopathy, conduction disorders, post-COVID-19 myopericarditis and heart failure was admitted to the hospital\u2019s cardiology department. Blood tests revealed an increase in CPK activity, troponin T elevation and high titers of anticardiac antibodies. Whole exome sequencing showed the presence of the pathogenic variant NM_213599:c.2272C&gt;T of the ANO5 gene. Results of the skeletal muscle biopsy excluded the diagnosis of systemic amyloidosis. Microscopy of the muscle fragment demonstrated sclerosis of the perimysium, moderate lymphoid infiltration, sclerosis of the microvessels, dystrophic changes and a lack of cross striations in the muscle fibers. Hypertrophy of the LV with a low contractile ability, atrial fibrillation, weakness of the distal skeletal muscles and increased plasma CPK activity and the results of the skeletal muscle biopsy suggested a diagnosis of a late form of distal myopathy (Miyoshi-like distal myopathy, MMD3). Post-COVID-19 myopericarditis, for which genetically modified myocardium could serve as a favorable background, caused heart failure decompensation.<\/jats:p>","DOI":"10.3390\/genes14071332","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T02:05:02Z","timestamp":1687745102000},"page":"1332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypertrophic Cardiomyopathy Complicated by Post-COVID-19 Myopericarditis in Patient with ANO5-Related Distal Myopathy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5253-793X","authenticated-orcid":false,"given":"Olga","family":"Blagova","sequence":"first","affiliation":[{"name":"V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Lutokhina","sequence":"additional","affiliation":[{"name":"V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-169X","authenticated-orcid":false,"given":"Marina","family":"Vukolova","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Pirozhkov","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Sarkisova","sequence":"additional","affiliation":[{"name":"V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Ainetdinova","sequence":"additional","affiliation":[{"name":"V.N. Vinogradov Faculty Therapeutic Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-7492","authenticated-orcid":false,"given":"Anushree","family":"Das","sequence":"additional","affiliation":[{"name":"N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5852-913X","authenticated-orcid":false,"given":"Marina","family":"Krot","sequence":"additional","affiliation":[{"name":"Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Smolyannikova","sequence":"additional","affiliation":[{"name":"Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Litvitsky","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, I.M. 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Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"B90","DOI":"10.1093\/eurheartj\/suz033","article-title":"Myocarditis evolving in cardiomyopathy: When genetics and offending causes work together","volume":"21","author":"Cannata","year":"2019","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/j.jacc.2015.10.049","article-title":"Genetically Vulnerable Myocardium May Predispose to Myocarditis","volume":"66","author":"Campuzano","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-3-030-35276-9_4","article-title":"Genetic Basis of Myocarditis: Myth or Reality? 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Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.gendis.2022.01.001","article-title":"ANO5-related muscle diseases: From clinics and genetics to pathology and research strategies","volume":"9","author":"Christiansen","year":"2022","journal-title":"Genes Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijcard.2012.09.070","article-title":"Dilated cardiomyopathy in patients with mutations in anoctamin 5","volume":"168","author":"Wahbi","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Soontrapa, P., and Liewluck, T. (2022). Anoctamin 5 (ANO5) Muscle Disorders: A Narrative Review. 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Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41591-020-1051-9","article-title":"An inflammatory cytokine signature predicts COVID-19 severity and survival","volume":"26","author":"Huang","year":"2020","journal-title":"Nat. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s10557-020-07071-0","article-title":"Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure","volume":"34","author":"Hanna","year":"2020","journal-title":"Cardiovasc. 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