{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:24:09Z","timestamp":1789957449283,"version":"4.0.1"},"reference-count":70,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Texas A&amp;M AgriLife Research","award":["004727"],"award-info":[{"award-number":["004727"]}]},{"name":"Texas A&amp;M AgriLife Research","award":["IDA01566"],"award-info":[{"award-number":["IDA01566"]}]},{"name":"Idaho Department of Commerce and Agriculture via the Idaho Global Entrepreneurial Mission","award":["004727"],"award-info":[{"award-number":["004727"]}]},{"name":"Idaho Department of Commerce and Agriculture via the Idaho Global Entrepreneurial Mission","award":["IDA01566"],"award-info":[{"award-number":["IDA01566"]}]},{"name":"Agriculture and Food Research Initiative Hatch","award":["004727"],"award-info":[{"award-number":["004727"]}]},{"name":"Agriculture and Food Research Initiative Hatch","award":["IDA01566"],"award-info":[{"award-number":["IDA01566"]}]},{"name":"USDA National Institute of Food and Agriculture","award":["004727"],"award-info":[{"award-number":["004727"]}]},{"name":"USDA National Institute of Food and Agriculture","award":["IDA01566"],"award-info":[{"award-number":["IDA01566"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The anthelmintic resistance of gastrointestinal nematodes (GINs) poses a significant threat to sheep worldwide, but genomic selection can serve as an alternative to the use of chemical treatment as a solution for parasitic infection. The objective of this study is to conduct genome-wide association studies (GWASs) to identify single nucleotide polymorphisms (SNPs) in Rambouillet (RA) and Dorper \u00d7 White Dorper (DWD) lambs associated with the biological response to a GIN infection. All lambs were genotyped with a medium-density genomic panel with 40,598 markers used for analysis. Separate GWASs were conducted using fecal egg counts (FECs) from lambs (&lt;1 year of age) that acquired their artificial infections via an oral inoculation of 10,000 Haemonchus contortus larvae (n = 145) or naturally while grazing on pasture (n = 184). A GWAS was also performed for packed cell volume (PCV) in artificially GIN-challenged lambs. A total of 26 SNPs exceeded significance and 21 SNPs were in or within 20 kb of genes such as SCUBE1, GALNT6, IGF1R, CAPZB and PTK2B. The ontology analysis of candidate genes signifies the importance of immune cell development, mucin production and cellular signaling for coagulation and wound healing following epithelial damage in the abomasal gastric pits via H. contortus during GIN infection in lambs. These results add to a growing body of the literature that promotes the use of genomic selection for increased sheep resistance to GINs.<\/jats:p>","DOI":"10.3390\/genes14071342","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T01:42:02Z","timestamp":1687830122000},"page":"1342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes"],"prefix":"10.3390","volume":"14","author":[{"given":"Jacob W.","family":"Thorne","sequence":"first","affiliation":[{"name":"Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID 83844, USA"},{"name":"Texas A&M AgriLife Research and Extension, San Angelo, TX 76901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Redden","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research and Extension, San Angelo, TX 76901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Bowdridge","sequence":"additional","affiliation":[{"name":"Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle M.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan R.","family":"Stegemiller","sequence":"additional","affiliation":[{"name":"Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-3473","authenticated-orcid":false,"given":"Brenda M.","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID 83844, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/age.13067","article-title":"Evolution of the sheep industry and genetic research in the United States: Opportunities for convergence in the twenty-first century","volume":"52","author":"Thorne","year":"2021","journal-title":"Anim. 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