{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:09Z","timestamp":1792789269463,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Swine Innovation Team Construction Project of National Modern Agricultural Industry Technology System of China","award":["sccxtd-2023-08"],"award-info":[{"award-number":["sccxtd-2023-08"]}]},{"name":"Sichuan Swine Innovation Team Construction Project of National Modern Agricultural Industry Technology System of China","award":["2022NSFSC1649"],"award-info":[{"award-number":["2022NSFSC1649"]}]},{"name":"Sichuan Swine Innovation Team Construction Project of National Modern Agricultural Industry Technology System of China","award":["2021ZDZX0012"],"award-info":[{"award-number":["2021ZDZX0012"]}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["sccxtd-2023-08"],"award-info":[{"award-number":["sccxtd-2023-08"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2022NSFSC1649"],"award-info":[{"award-number":["2022NSFSC1649"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2021ZDZX0012"],"award-info":[{"award-number":["2021ZDZX0012"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["sccxtd-2023-08"],"award-info":[{"award-number":["sccxtd-2023-08"]}]},{"name":"Sichuan Science and Technology Program","award":["2022NSFSC1649"],"award-info":[{"award-number":["2022NSFSC1649"]}]},{"name":"Sichuan Science and Technology Program","award":["2021ZDZX0012"],"award-info":[{"award-number":["2021ZDZX0012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>As an environmentally-friendly agent, slightly acidic electrolyzed water (SAEW) was introduced in drinking water of newly weaned piglets for diarrhea prevention. In total, 72 piglets were employed and 3% SAEW was added into the normal temperature and warm (30 \u00b0C) tap water, respectively, for this 33-day feeding experiment. It was found that the total bacteria and coliforms in the drinking water were reduced by 70% and 100%, respectively, with the addition of 3% SAEW. After SAEW treatment, the average daily water and feed intakes of piglets were increased during the first 16 days, and the diarrhea rate was reduced by 100%, with not one case of diarrhea recorded at the end of the experiment. The microbiome results demonstrated that SAEW decreased the diversity of caecum bacteria with normal tap water supplied, and increased the richness of the caecum bacteria with warm tap water supplied. SAEW also increased the abundance of potentially beneficial genera Sutterella and Ruminococcaceae_UCG-005 and reduced the abundance of pathogenic Faecalibacterium. Moreover, twelve metabolic functions belonging to the cluster of metabolism and organismal functions, including digestion and the endocrine and excretory systems, were greatly enhanced. Correlation analysis indicated that the influence of intestinal pathogens on water and feed intakes and the diarrhea of piglets were decreased by SAEW. The results suggest that SAEW can be used as an antibiotic substitute to prevent diarrhea in newly weaned piglets.<\/jats:p>","DOI":"10.3390\/genes14071398","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:33:42Z","timestamp":1688517222000},"page":"1398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Slightly Acidic Electrolyzed Water on Growth, Diarrhea and Intestinal Bacteria of Newly Weaned Piglets"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaoxia","family":"Hao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"},{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyuan","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"},{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mailin","family":"Gan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"},{"name":"Farm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Sichuan Agricultural University, 211 Huimin Ave, Chengdu 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.3382\/ps.2014-03909","article-title":"Benefits of neutral electrolyzed oxidizing water as a drinking water additive for broiler chickens","volume":"93","author":"Kump","year":"2014","journal-title":"Poultry Sci."},{"key":"ref_2","first-page":"65","article-title":"Praxisrelevante Aspekte der Wasserversorgung von Nutz-und Liebhabertieren","volume":"30","author":"Kamphues","year":"2002","journal-title":"Ubers. 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