{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:38:51Z","timestamp":1791491931084,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad de La Sabana","award":["MED-96-2008"],"award-info":[{"award-number":["MED-96-2008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The transcription factors Oct4, Sox2, Klf4, and c-Myc enable the reprogramming of somatic cells into induced pluripotent cells. Reprogramming generates newly differentiated cells for potential therapies in cancer, neurodegenerative diseases, and rejuvenation processes. In cancer therapies, these transcription factors lead to a reduction in the size and aggressiveness of certain tumors, such as sarcomas, and in neurodegenerative diseases, they enable the production of dopaminergic cells in Parkinson\u2019s disease, the replacement of affected neuronal cells in olivopontocerebellar atrophy, and the regeneration of the optic nerve. However, there are limitations, such as an increased risk of cancer development when using Klf4 and c-Myc and the occurrence of abnormal dyskinesias in the medium term, possibly generated by the uncontrolled growth of differentiated dopaminergic cells and the impairment of the survival of the new cells. Therefore, the Yamanaka transcription factors have shown therapeutic potential through cell reprogramming for some carcinomas, neurodegenerative diseases, and rejuvenation. However, the limitations found in the studies require further investigation before the use of these transcription factors in humans.<\/jats:p>","DOI":"10.3390\/genes14091697","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:23:25Z","timestamp":1693189405000},"page":"1697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Application of the Yamanaka Transcription Factors Oct4, Sox2, Klf4, and c-Myc from the Laboratory to the Clinic"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-1075","authenticated-orcid":false,"given":"Marisol","family":"Aguirre","sequence":"first","affiliation":[{"name":"Department of Genetics, Fundaci\u00f3n Valle del Lili, Cali 760026, Colombia"},{"name":"Faculty of Medicine, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Escobar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-175X","authenticated-orcid":false,"given":"Sebasti\u00e1n","family":"Forero Am\u00e9zquita","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-8193","authenticated-orcid":false,"given":"David","family":"Cubillos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Vanegas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paula","family":"Tarazona","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Atuesta Escobar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Camilo","family":"Blanco","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0338-6258","authenticated-orcid":false,"given":"Luis Gustavo","family":"Celis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de La Sabana, Km 7, Autopista Norte de Bogot\u00e1, Ch\u00eda 250001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1007\/s12015-021-10200-3","article-title":"An overview on promising somatic cell sources utilized for the efficient generation of induced pluripotent stem cells","volume":"17","author":"Ray","year":"2021","journal-title":"Stem Cell Rev. 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