{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:43:46Z","timestamp":1790207026932,"version":"4.1.0"},"reference-count":181,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Key Research and Development Program of the Sichuan Provincial Science and Technology Program","award":["2023YFN0001"],"award-info":[{"award-number":["2023YFN0001"]}]},{"name":"The Key Research and Development Program of the Sichuan Provincial Science and Technology Program","award":["ZYN2023044"],"award-info":[{"award-number":["ZYN2023044"]}]},{"name":"Fundamental Research Funds for the Central Universities, Southwest Minzu University","award":["2023YFN0001"],"award-info":[{"award-number":["2023YFN0001"]}]},{"name":"Fundamental Research Funds for the Central Universities, Southwest Minzu University","award":["ZYN2023044"],"award-info":[{"award-number":["ZYN2023044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The yak (Bos grunniens) is a unique breed living on the Qinghai\u2013Tibet Plateau and its surrounding areas, providing locals with a variety of vital means of living and production. However, the yak has poor sexual maturity and low fertility. High-quality mature oocytes are the basis of animal breeding technology. Recently, in vitro culturing of oocytes and embryo engineering technology have been applied to yak breeding. However, compared to those observed in vivo, the maturation rate and developmental capacity of in vitro oocytes are still low, which severely limits the application of in vitro fertilization and embryo production in yaks. This review summarizes the endogenous and exogenous factors affecting the in vitro maturation (IVM) and developmental ability of yak oocytes reported in recent years and provides a theoretical basis for obtaining high-quality oocytes for in vitro fertilization and embryo production in yaks.<\/jats:p>","DOI":"10.3390\/genes14101882","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:42:12Z","timestamp":1695865332000},"page":"1882","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro"],"prefix":"10.3390","volume":"14","author":[{"given":"Luoyu","family":"Mo","sequence":"first","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-7806","authenticated-orcid":false,"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"},{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China"},{"name":"Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-122X","authenticated-orcid":false,"given":"Xianrong","family":"Xiong","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"},{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China"},{"name":"Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoliang","family":"Lan","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"},{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China"},{"name":"Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"},{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China"},{"name":"Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China"},{"name":"Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Ministry of Education, Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Key Laboratory of Sichuan Province, Chengdu 610041, China"},{"name":"Key Laboratory of Animal Science of National Ethnic Affairs Commission of China, Southwest Minzu University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"946893","DOI":"10.3389\/fvets.2022.946893","article-title":"Integration of transcriptomic and metabolomic analysis of the mechanism of dietary N-carbamoylglutamate in promoting follicle development in yaks","volume":"9","author":"Zhou","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/S0093-691X(02)01172-X","article-title":"Reproduction in female yaks (Bos grunniens) and opportunities for improvement","volume":"59","author":"Zi","year":"2003","journal-title":"Theriogenology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e9851","DOI":"10.7717\/peerj.9851","article-title":"Comparing the gastrointestinal barrier function between growth-retarded and normal yaks on the Qinghai-Tibetan Plateau","volume":"8","author":"Ma","year":"2020","journal-title":"PeerJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.theriogenology.2023.06.023","article-title":"Molecular cloning and characterization of STC1 gene and its functional analyses in yak (Bos grunniens) cumulus granulosa cells","volume":"208","author":"Yang","year":"2023","journal-title":"Theriogenology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/10495398.2021.1946552","article-title":"Identification of microRNA transcriptome throughout the lifespan of yak (Bos grunniens) corpus luteum","volume":"34","author":"Yin","year":"2023","journal-title":"Anim. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17677","DOI":"10.1002\/jcp.28394","article-title":"FGF10 enhances yak oocyte fertilization competence and subsequent blastocyst quality and regulates the levels of CD9, CD81, DNMT1, and DNMT3B","volume":"234","author":"Pan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cryobiol.2014.01.012","article-title":"Developmental competence of frozen-thawed yak (Bos grunniens) oocytes followed by in vitro maturation and fertilization","volume":"68","author":"Niu","year":"2014","journal-title":"Cryobiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.anireprosci.2006.09.018","article-title":"In vitro development of yak (Bos grunniens) embryos generated by interspecies nuclear transfer","volume":"101","author":"Li","year":"2007","journal-title":"Anim. Reprod. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.theriogenology.2006.10.022","article-title":"Nuclear reprogramming in embryos generated by the transfer of yak (Bos grunniens) nuclei into bovine oocytes and comparison with bovine-bovine SCNT and bovine IVF embryos","volume":"67","author":"Li","year":"2007","journal-title":"Theriogenology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/mrd.23637","article-title":"Regulation of oocyte maturation: Role of conserved ERK signaling","volume":"89","author":"Das","year":"2022","journal-title":"Mol. Reprod. Dev."},{"key":"ref_11","first-page":"2165","article-title":"Histone acetyltransferase KAT8 is essential for mouse oocyte development by regulating reactive oxygen species levels","volume":"144","author":"Yin","year":"2017","journal-title":"Development"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2741\/S383","article-title":"Oocyte maturation: A story of arrest and release","volume":"5","author":"Sen","year":"2013","journal-title":"Front. Biosci. (Schol. Ed.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.18632\/aging.101381","article-title":"Mammalian oogenesis and female reproductive aging","volume":"10","author":"Duncan","year":"2018","journal-title":"Aging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.fertnstert.2021.03.004","article-title":"In vitro growth and maturation of primordial follicles and immature oocytes","volume":"115","author":"Telfer","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Str\u0105czy\u0144ska, P., Papis, K., Morawiec, E., Czerwi\u0144ski, M., Gajewski, Z., Olejek, A., and Bednarska-Czerwi\u0144ska, A. (2022). Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes. Reprod. Biol. Endocrinol., 20.","DOI":"10.1186\/s12958-022-00906-5"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13360","DOI":"10.1111\/acel.13360","article-title":"Single human oocyte transcriptome analysis reveals distinct maturation stage-dependent pathways impacted by age","volume":"20","author":"Llonch","year":"2021","journal-title":"Aging Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1017\/S0967199413000233","article-title":"Developmental potential of in vitro or in vivo matured oocytes","volume":"23","author":"Alcoba","year":"2015","journal-title":"Zygote"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1023\/B:JARG.0000042008.83699.cc","article-title":"Comparison of maturation, fertilization, development, and gene expression of mouse oocytes grown in vitro and in vivo","volume":"21","author":"Kim","year":"2004","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_19","unstructured":"Liu, B. (2013). Optimization of Yak In-Vitro Embryo Production and Analysis of Apoptosis. [Ph.D. Thesis, Gansu Agricultural University]."},{"key":"ref_20","first-page":"7","article-title":"White yak oocyte maturation in vitro","volume":"04","author":"Yan","year":"2006","journal-title":"China Herbiv. Sci."},{"key":"ref_21","first-page":"14","article-title":"In vitro maturation of yak oocytes","volume":"38","author":"Yan","year":"2006","journal-title":"Anim. Husb. Vet. Med."},{"key":"ref_22","unstructured":"Li, T.Q. (2008). Oocytes In Vitro Maturation of Tianzhu White Yak. [Master\u2019s Thesis, Gansu Agricultural University]."},{"key":"ref_23","first-page":"40","article-title":"In vitro mature culture of Nyingchi yak oocytes","volume":"2","author":"Wang","year":"2018","journal-title":"J. Plateau Agric."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/biolre\/ioaa149","article-title":"The impact of transcription inhibition during in vitro maturation on the proteome of bovine oocytes","volume":"103","author":"Gegenfurtner","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2006.03.010","article-title":"Mining the oocyte transcriptome","volume":"17","author":"Lin","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1071\/RD03078","article-title":"Gene transcription and regulation of oocyte maturation","volume":"16","author":"Rodriguez","year":"2004","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e22718","DOI":"10.1096\/fj.202201176RR","article-title":"A single-cell transcriptomic atlas characterizes cell types and their molecular features in yak ovarian cortex","volume":"37","author":"Pei","year":"2023","journal-title":"Faseb J."},{"key":"ref_28","first-page":"722","article-title":"Transcriptome analysis of yak mataphase \u2161 (M\u2161) oocytes by a micro-tanscriptome sequencing method","volume":"45","author":"Lan","year":"2014","journal-title":"Acta Vet. Zootech. Sin."},{"key":"ref_29","first-page":"1099","article-title":"Differential transcriptome analysis of yak oocytes in vitro maturation","volume":"47","author":"Lan","year":"2017","journal-title":"Sci. Sin. (Vitea)"},{"key":"ref_30","first-page":"1804","article-title":"Proteomic profile identification and analysis of Tibet yak oocytes","volume":"38","author":"Zhao","year":"2018","journal-title":"Chin. J. Vet. Sci."},{"key":"ref_31","unstructured":"Huang, Y. (2016). iTRAQ-Based Comparative Proteomic Analysis of Oocytes In Vitro Maturation for Yak. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1056\/NEJMra1402513","article-title":"The Key Role of Epigenetics in Human Disease Prevention and Mitigation","volume":"378","author":"Feinberg","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-15-8104-5_1","article-title":"Overview of Histone Modification","volume":"1283","author":"Zhang","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature14192","article-title":"Function and information content of DNA methylation","volume":"517","year":"2015","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/mrd.21306","article-title":"Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development","volume":"78","author":"Golding","year":"2011","journal-title":"Mol. Reprod. Dev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dev.050849","article-title":"Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells","volume":"139","author":"Saitou","year":"2012","journal-title":"Development"},{"key":"ref_38","unstructured":"Li, Q. (2020). Application of Ascorbic Aicd in the Regulation of DNA Methylation in Yak Oocytes and IVF Embryos. [Ph.D. Thesis, Gansu Agricultural University]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/mrd.23230","article-title":"DNA methylation regulated by ascorbic acids in yak preimplantation embryo helps to improve blastocyst quality","volume":"86","author":"Li","year":"2019","journal-title":"Mol. Reprod. Dev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-1-0716-2433-3_18","article-title":"Histone Modification Analysis of Low-Mappability Regions","volume":"2519","author":"Masai","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tig.2015.10.007","article-title":"Lateral Thinking: How Histone Modifications Regulate Gene Expression","volume":"32","author":"Lawrence","year":"2016","journal-title":"Trends Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3327","article-title":"Molecular mechanisms and potential functions of histone demethylases","volume":"13","author":"Kooistra","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1038\/s41467-022-30928-x","article-title":"Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging","volume":"13","author":"Wu","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"He, M., Zhang, T., Yang, Y., and Wang, C. (2021). Mechanisms of Oocyte Maturation and Related Epigenetic Regulation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.654028"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature19360","article-title":"Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition","volume":"537","author":"Dahl","year":"2016","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27959","DOI":"10.18632\/oncotarget.8563","article-title":"KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells","volume":"7","author":"Kong","year":"2016","journal-title":"Oncotarget"},{"key":"ref_47","unstructured":"Han, J. (2019). Analysis of the Expression Profile of Yak KDM1A and Its Effect on Meiosis Maturation of Oocyte. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_48","first-page":"2433","article-title":"Effects of KDM1A on the meiotic maturation and develomental potential of yak oocytes","volume":"51","author":"Han","year":"2020","journal-title":"Acta Vet. Zootechica Sin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","article-title":"Histone demethylation by a family of JmjC domain-containing proteins","volume":"439","author":"Tsukada","year":"2006","journal-title":"Nature"},{"key":"ref_50","unstructured":"Cai, W.Y. (2018). The Study of Cloning, Expression Profile of Yak KDM2 and Its Role in the Meiosis of Oocyte. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/asj.12360","article-title":"Sirt1 protects pig oocyte against in vitro aging","volume":"86","author":"Ma","year":"2015","journal-title":"Anim. Sci. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e13204","DOI":"10.1111\/acel.13204","article-title":"Sirt1 sustains female fertility by slowing age-related decline in oocyte quality required for post-fertilization embryo development","volume":"19","author":"Iljas","year":"2020","journal-title":"Aging Cell"},{"key":"ref_53","first-page":"2440","article-title":"Effects of SIRT1 on the in vitro maturation and aging of yak oocytes","volume":"50","author":"Xiong","year":"2019","journal-title":"Acta Vet. Et Zootech. Sin."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Grocock","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"9779","DOI":"10.1073\/pnas.1630797100","article-title":"MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms","volume":"100","author":"Zeng","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/biolre\/ioaa098","article-title":"MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation","volume":"103","author":"Dehghan","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.theriogenology.2022.04.025","article-title":"MicroRNA-101 regulates oocyte maturation in vitro via targeting HAS2 in porcine cumulus cells","volume":"187","author":"Luo","year":"2022","journal-title":"Theriogenology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.theriogenology.2022.02.019","article-title":"MiRNA-155 inhibition enhances porcine embryo preimplantation developmental competence by upregulating ZEB2 and downregulating ATF4","volume":"183","author":"Tanga","year":"2022","journal-title":"Theriogenology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/rda.12754","article-title":"Identification of candidate miRNAs and expression profile of yak oocytes before and after in vitro maturation by high-throughput sequencing","volume":"51","author":"Xiong","year":"2016","journal-title":"Reprod. Domest. Anim."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/rda.14119","article-title":"MicroRNA-342-3p regulates yak oocyte meiotic maturation by targeting DNA methyltransferase 1","volume":"57","author":"Xiong","year":"2022","journal-title":"Reprod. Domest. Anim."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2826.2001.00651.x","article-title":"Localization of the melatonin-related receptor in the rodent brain and peripheral tissues","volume":"13","author":"Drew","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"ref_62","first-page":"3387","article-title":"Study on the expression and subcellular localization of G Protein-coupled Receptor 50 during in vitro maturation process of yak oocytes","volume":"48","author":"Yao","year":"2021","journal-title":"China Anim. Husb. Vet. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.theriogenology.2022.01.009","article-title":"GPR50 participates in and promotes yak oocyte maturation: A new potential oocyte regulatory molecule","volume":"181","author":"Chen","year":"2022","journal-title":"Theriogenology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1071\/RD20099","article-title":"Effects of epidermal growth factor and progesterone on oocyte meiotic resumption and the expression of maturation-related transcripts during prematuration of oocytes from small and medium-sized bovine antral follicles","volume":"32","author":"Bezerra","year":"2020","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s11427-019-1646-y","article-title":"Roles of insulin-like growth factor II in regulating female reproductive physiology","volume":"63","author":"Muhammad","year":"2020","journal-title":"Sci. China Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.theriogenology.2022.10.005","article-title":"Optimizing swine in vitro embryo production with growth factor and antioxidant supplementation during oocyte maturation","volume":"194","author":"Currin","year":"2022","journal-title":"Theriogenology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/GCO.0b013e3282fe743b","article-title":"The importance of growth factors for preimplantation embryo development and in-vitro culture","volume":"20","author":"Richter","year":"2008","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_68","first-page":"331","article-title":"Decreased growth factor expression through RNA interference inhibits development of mouse preimplantation embryos","volume":"59","author":"Dadi","year":"2009","journal-title":"Comp. Med."},{"key":"ref_69","first-page":"85","article-title":"Effect of Epidermal Growth Factors (EGF) on the Maturation and Developmental Competence of Buffalos\u2019 Oocytes and Embryo Stages In Vitro","volume":"1","author":"Yousef","year":"2018","journal-title":"SVU-Int. J. Vet. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/humrep\/des099","article-title":"Effects of combined epidermal growth factor, brain-derived neurotrophic factor and insulin-like growth factor-1 on human oocyte maturation and early fertilized and cloned embryo development","volume":"27","author":"Yu","year":"2012","journal-title":"Hum. Reprod."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.anireprosci.2006.01.011","article-title":"Supplements to in vitro maturation media affect the production of bovine blastocysts and their apoptotic index but not the proportions of matured and apoptotic oocytes","volume":"97","author":"Warzych","year":"2007","journal-title":"Anim. Reprod. Sci."},{"key":"ref_72","first-page":"865","article-title":"The effect of in vitro culture time and EGF on the yak oocyte maturation and parthenogenetic embryos in vitro development","volume":"39","author":"Ma","year":"2013","journal-title":"J. Southwest Minzu Univ. (Nat. Sci. Ed.)"},{"key":"ref_73","first-page":"2439","article-title":"The expression of EGF and EGFR in yak oocyte and its function on development competence of embryo","volume":"48","author":"Pan","year":"2015","journal-title":"Sci. Agric. Sin."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fendo.2020.00024","article-title":"The IGF\/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease","volume":"11","author":"Stuard","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Bailes, J., and Soloviev, M. (2021). Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules, 11.","DOI":"10.3390\/biom11020217"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cryobiol.2015.10.150","article-title":"Developmental competence of mature yak vitrified-warmed oocytes is enhanced by IGF-I via modulation of CIRP during in vitro maturation","volume":"71","author":"Pan","year":"2015","journal-title":"Cryobiology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"109398","DOI":"10.1016\/j.intimp.2022.109398","article-title":"Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K\/Akt\/Nrf2 signaling pathway","volume":"113","author":"Liu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cytogfr.2015.10.001","article-title":"FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease","volume":"28","author":"Itoh","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1165\/rcmb.2004-0242OC","article-title":"Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism","volume":"32","author":"Upadhyay","year":"2005","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12931-022-02193-5","article-title":"Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis","volume":"23","author":"Jiang","year":"2022","journal-title":"Respir. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.domaniend.2010.06.006","article-title":"Fibroblast growth factor-10 maintains the survival and promotes the growth of cultured goat preantral follicles","volume":"39","author":"Chaves","year":"2010","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_82","first-page":"4934","article-title":"The expression pattern of fibroblast growth factor 10 and its receptors during buffalo follicular development","volume":"11","author":"Du","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Rose-John, S. (2018). Interleukin-6 Family Cytokines. Cold Spring Harb. Perspect. Biol., 10.","DOI":"10.1101\/cshperspect.a028415"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"997709","DOI":"10.3389\/fvets.2022.997709","article-title":"Leukemia inhibitory factor enhances the development and subsequent blastocysts quality of yak oocytes in vitro","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Cao, B., Qin, J., Pan, B., Qazi, I.H., Ye, J., Fang, Y., and Zhou, G. (2022). Oxidative Stress and Oocyte Cryopreservation: Recent Advances in Mitigation Strategies Involving Antioxidants. Cells, 11.","DOI":"10.3390\/cells11223573"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1089\/ars.2006.8.1865","article-title":"Redefining oxidative stress","volume":"8","author":"Jones","year":"2006","journal-title":"Antioxid. Redox Signal"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"7966","DOI":"10.1002\/jcp.30468","article-title":"Oxidative stress in oocyte aging and female reproduction","volume":"236","author":"Wang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Prasad, S., Tiwari, M., Pandey, A.N., Shrivastav, T.G., and Chaube, S.K. (2016). Impact of stress on oocyte quality and reproductive outcome. J. Biomed. Sci., 23.","DOI":"10.1186\/s12929-016-0253-4"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1080\/10408398.2015.1060940","article-title":"Vitamin A and the epigenome","volume":"57","author":"Reifen","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1262\/jrd.51.23","article-title":"The roles of vitamin A for cytoplasmic maturation of bovine oocytes","volume":"51","author":"Ikeda","year":"2005","journal-title":"J. Reprod. Dev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"dev194977","DOI":"10.1242\/dev.194977","article-title":"Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse","volume":"148","author":"Feng","year":"2021","journal-title":"Development"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/en.2014-1524","article-title":"Role of retinoic acid and platelet-derived growth factor receptor cross talk in the regulation of neonatal gonocyte and embryonal carcinoma cell differentiation","volume":"156","author":"Manku","year":"2015","journal-title":"Endocrinology"},{"key":"ref_93","first-page":"4707","article-title":"Effects of vitamin A on the maturation and subsequent development of yak oocytes in vitro","volume":"49","author":"Ji","year":"2022","journal-title":"China Anim. Husb. Vet. Med."},{"key":"ref_94","unstructured":"Wang, Y.L. (2022). A Preliminary Study on the Effect of Vitamin A on the Maturation of Yak Oocytes In Vitro and Its Mechanism of Actin. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00240-016-0868-7","article-title":"Ascorbic acid intake and oxalate synthesis","volume":"44","author":"Knight","year":"2016","journal-title":"Urolithiasis"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e13702","DOI":"10.1111\/asj.13702","article-title":"Ascorbic acid protects the toxic effects of aflatoxin B(1) on yak oocyte maturation","volume":"93","author":"Li","year":"2022","journal-title":"Anim. Sci. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0079-6123(08)81008-4","article-title":"Melatonin: A multitasking molecule","volume":"181","author":"Reiter","year":"2010","journal-title":"Prog. Brain Res."},{"key":"ref_98","first-page":"1","article-title":"Research of metatonin inhibits oxidative stress and promotes oocyte maturation of yak in vitro","volume":"51","author":"Peng","year":"2021","journal-title":"Chin. Qinghai J. Anim. Vet. Sci."},{"key":"ref_99","unstructured":"Peng, W. (2019). Analysis of Ovarian Differences in Cold and Warm Season and the Effects of Melatonin on Oocyte Maturation and Embryo Development of Yak In Vitro. [Ph.D. Thesis, Northwest A&F University]."},{"key":"ref_100","unstructured":"Li, R.Z. (2021). Effects and Mechanisms of Low Oxygen Concentration on In Vitro Maturation and Developmental Competence of Yak Oocytes. [Ph.D. Thesis, Gansu Agricultural University]."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4155\/fmc-2019-0215","article-title":"The Zn(S-pr-thiosal)(2) complex attenuates murine breast cancer growth by inducing apoptosis and G1\/S cell cycle arrest","volume":"12","author":"Benazic","year":"2020","journal-title":"Future Med. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.autrev.2014.11.008","article-title":"Zinc and its role in immunity and inflammation","volume":"14","author":"Bonaventura","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s12011-017-1217-6","article-title":"Effects of Zinc Supplementation During In Vitro Maturation on Meiotic Maturation of Oocytes and Developmental Capacity in Yak","volume":"185","author":"Xiong","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_104","unstructured":"Hu, J.J. (2017). Effects of Zinc Supplementation on Meiosis Maturation and Development of Yak Oocytes. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_105","first-page":"14","article-title":"Effects of Zinc on bovine oocytes in vitro maturation and early embryonic development","volume":"55","author":"Feng","year":"2019","journal-title":"Chin. J. Anim. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"ref_107","unstructured":"Chen, Z. (2022). Mechanism of Ca2+ Regulating Maturation through CaMK\u2161 in Yak. [Master\u2019s Thesis, Northwest Minzu University]."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"39428","DOI":"10.1074\/jbc.M305542200","article-title":"Cell death caused by selenium deficiency and protective effect of antioxidants","volume":"278","author":"Saito","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3390\/molecules14031263","article-title":"Selenium as an essential micronutrient: Roles in cell cycle and apoptosis","volume":"14","author":"Zeng","year":"2009","journal-title":"Molecules"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Avery, J.C., and Hoffmann, P.R. (2018). Selenium, Selenoproteins, and Immunity. Nutrients, 10.","DOI":"10.3390\/nu10091203"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/asj.12894","article-title":"Selenium supplementation during in vitro maturation enhances meiosis and developmental capacity of yak oocytes","volume":"89","author":"Xiong","year":"2018","journal-title":"Anim. Sci. J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40164-020-00191-1","article-title":"Complex roles of cAMP-PKA-CREB signaling in cancer","volume":"9","author":"Zhang","year":"2020","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Pan, B., and Li, J. (2019). The art of oocyte meiotic arrest regulation. Reprod. Biol. Endocrinol., 17.","DOI":"10.1186\/s12958-018-0445-8"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1262\/jrd.2016-016","article-title":"Porcine oocyte maturation in vitro: Role of cAMP and oocyte-secreted factors\u2014A practical approach","volume":"62","author":"Appeltant","year":"2016","journal-title":"J. Reprod. Dev."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Yang, C.R., Wei, Y., Qi, S.T., Chen, L., Zhang, Q.H., Ma, J.Y., Luo, Y.B., Wang, Y.P., Hou, Y., and Schatten, H. (2012). The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038807"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ydbio.2008.01.018","article-title":"Generation of mouse oocytes defective in cAMP synthesis and degradation: Endogenous cyclic AMP is essential for meiotic arrest","volume":"316","author":"Vaccari","year":"2008","journal-title":"Dev. Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2018.11.002","article-title":"Role of cAMP modulator supplementations during oocyte in vitro maturation in domestic animals","volume":"199","year":"2018","journal-title":"Anim. Reprod. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/15384101.2022.2026704","article-title":"Molecular determinants of the meiotic arrests in mammalian oocytes at different stages of maturation","volume":"21","author":"Ozturk","year":"2022","journal-title":"Cell Cycle"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.anireprosci.2017.08.013","article-title":"Supplementation of cilostazol during in vitro maturation enhances the meiosis and developmental competence of yak oocytes by influencing cAMP content and mRNA expression","volume":"186","author":"Xiong","year":"2017","journal-title":"Anim. Reprod. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.fct.2007.09.004","article-title":"Resveratrol modulates roscovitine-mediated cell cycle arrest of human MCF-7 breast cancer cells","volume":"46","author":"Kramer","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"ref_121","unstructured":"Liu, Y. (2022). The Effects of Roscovitine on Granulosa Cell Culture and Oocyte In Vitro Maturation of the Yak. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1017\/S0967199416000289","article-title":"Meiotic arrest as an alternative to increase the production of bovine embryos by somatic cell nuclear transfer","volume":"25","author":"Caixeta","year":"2017","journal-title":"Zygote"},{"key":"ref_123","unstructured":"Jing, T. (2021). The Effects of CNP on Oocyte Maturation and Embryo Development of the Yak. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1210\/me.2009-0033","article-title":"Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes","volume":"23","author":"Wang","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Paczkowski, M., Silva, E., Schoolcraft, W.B., and Krisher, R.L. (2013). Comparative importance of fatty acid beta-oxidation to nuclear maturation, gene expression, and glucose metabolism in mouse, bovine, and porcine cumulus oocyte complexes. Biol. Reprod., 88.","DOI":"10.1095\/biolreprod.113.108548"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1530\/REP-14-0015","article-title":"Fatty acid metabolism during maturation affects glucose uptake and is essential to oocyte competence","volume":"148","author":"Paczkowski","year":"2014","journal-title":"Reproduction"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/REP-09-0345","article-title":"The pivotal role of glucose metabolism in determining oocyte developmental competence","volume":"139","author":"Gilchrist","year":"2010","journal-title":"Reproduction"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/asj.13015","article-title":"Sucrose assists selection of high-quality oocytes in pigs","volume":"89","author":"Nguyen","year":"2018","journal-title":"Anim. Sci. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1472-6483(10)60764-X","article-title":"Oocyte cryopreservation: Clinical outcome of slow-cooling protocols differing in sucrose concentration","volume":"14","author":"Cino","year":"2007","journal-title":"Reprod. Biomed. Online"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1017\/S0967199419000856","article-title":"Influence of oocyte selection, activation with a zinc chelator and inhibition of histone deacetylases on cloned porcine embryo and chemically activated oocytes development","volume":"28","author":"Ongaratto","year":"2020","journal-title":"Zygote"},{"key":"ref_131","first-page":"155","article-title":"Effect of sugar on in vitro maturation and development competence of yak oocytes","volume":"44","author":"Shi","year":"2017","journal-title":"China Anim. Husb. Vet. Meducine"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Xiao, X., Zi, X.D., Niu, H.R., Xiong, X.R., Zhong, J.C., Li, J., Wang, L., and Wang, Y. (2014). Effect of addition of FSH, LH and proteasome inhibitor MG132 to in vitro maturation medium on the developmental competence of yak (Bos grunniens) oocytes. Reprod. Biol. Endocrinol., 12.","DOI":"10.1186\/1477-7827-12-30"},{"key":"ref_133","first-page":"1899","article-title":"The effects of Follicle-stimulating Hormone (FSH) on the expression of EGF and EGFR in yak oocytes and apoptpsis","volume":"49","author":"He","year":"2018","journal-title":"Acta Vet. Zootech. Sin."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/mend-4-1-13","article-title":"Regulation of aromatase mRNA and estradiol biosynthesis in rat ovarian granulosa and luteal cells by prolactin","volume":"4","author":"Krasnow","year":"1990","journal-title":"Mol. Endocrinol."},{"key":"ref_135","unstructured":"Duan, J.X. (2021). The Effect and Regulation of Estrogen to Autophagy in Procine Oocyte. [Ph.D. Thesis, Northwest A&F University]."},{"key":"ref_136","unstructured":"Yang, B.X. (2021). Study on the Role of Estradiol in Ovine Cumulus-Oocyte Complexes Cultured In Vitro. [Master\u2019s Thesis, Inner Mongolia Agricultural University]."},{"key":"ref_137","unstructured":"Lv, L.H., Li, F.Z., and Yue, W.B. (2008). Effect of different concentrations of estradiol added to maturation fluid on the maturation of goat oocytes. Heilongjiang Anim. Sci. Vet. Med., 37\u201338."},{"key":"ref_138","unstructured":"Jin, H.X., Sun, Y.P., Xin, Z.M., Su, Y.C., and Guo, Y.H. (2008). Effects of 17 beta-estradiol on maturation and embryo development competence of mouse oocytes in vitro. J. Zhengzhou Univ. (Med. Sci.), 1137\u20131139."},{"key":"ref_139","first-page":"5660","article-title":"Effect of 17-beta-estrodiol (E2) in procine oocytes maturation and fertilized embryos\u2019 development in vitro","volume":"54","author":"Xiao","year":"2015","journal-title":"Hubei Agric. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Pan, Y., Wang, M., Wang, L., Zhang, Q., Baloch, A.R., He, H., Xu, G., Soomro, J., Cui, Y., and Yu, S. (2020). Estrogen improves the development of yak (Bos grunniens) oocytes by targeting cumulus expansion and levels of oocyte-secreted factors during in vitro maturation. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0239151"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1365-2826.2010.02031.x","article-title":"The roles of RFamide-related peptide-3 in mammalian reproductive function and behaviour","volume":"22","author":"Kriegsfeld","year":"2010","journal-title":"J. Neuroendocrinol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1523\/JNEUROSCI.1062-20.2020","article-title":"RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses","volume":"41","author":"Mamgain","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Xiong, X., Hu, Y., Pan, B., Zhu, Y., Fei, X., Yang, Q., Xie, Y., Xiong, Y., Lan, D., and Fu, W. (2023). RFRP-3 Influences Apoptosis and Steroidogenesis of Yak Cumulus Cells and Compromises Oocyte Meiotic Maturation and Subsequent Developmental Competence. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087000"},{"key":"ref_144","first-page":"37","article-title":"Differential expression analysis of CYP19A1 during follicular development and oocyte maturation in yaks","volume":"51","author":"Sun","year":"2021","journal-title":"Gansu Anim. Husb. Vet."},{"key":"ref_145","first-page":"4283","article-title":"CYP19A1 promotes autophagy and early development ability of yak oocytes by regulating the levels of endogenous estradiol","volume":"53","author":"Wang","year":"2022","journal-title":"Acta Vet. Zootech. Sin."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1095\/biolreprod40.5.907","article-title":"Platelet-activating factor: A paracrine factor in preimplantation stages of reproduction?","volume":"40","author":"Harper","year":"1989","journal-title":"Biol. Reprod."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1439-0531.2007.00959.x","article-title":"The role of platelet-activating factor in the mammalian female reproductive tract","volume":"43","author":"Tiemann","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"ref_148","unstructured":"Wang, Q. (2019). The Effects of PAF on Oocyte Maturation and Embryo Development of the Yak. [Master\u2019s Thesis, Southwest Minzu University]."},{"key":"ref_149","first-page":"514","article-title":"Effects of PFA supplementation during in vitro maturation medium on yak oocyte development competence and gene expression","volume":"51","author":"Wang","year":"2020","journal-title":"Acta Vet. Zootech. Sin."},{"key":"ref_150","first-page":"1158","article-title":"Influence of different ovary storage temperature on oocyte in vitro maturation and discovery of yak oocyte maturation cultivation methods","volume":"49","author":"Pang","year":"2012","journal-title":"Xinjiang Agric. Sci."},{"key":"ref_151","first-page":"1","article-title":"The effect of yak ovarian transport condition on the oocytes quality and embryos in vitro development","volume":"39","author":"Ma","year":"2013","journal-title":"J. Southwest Minzu Univ. (Nat. Sci. Ed.)"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/mrd.23073","article-title":"Reduced oxygen concentration during in vitro oocyte maturation alters global DNA methylation in the maternal pronucleus of subsequent zygotes in cattle","volume":"85","author":"Bennemann","year":"2018","journal-title":"Mol. Reprod. Dev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000493162","article-title":"Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering","volume":"205","author":"Fathollahipour","year":"2018","journal-title":"Cells Tissues Organs"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"F33","DOI":"10.1530\/REP-20-0509","article-title":"HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and ovarian function: Follicle development, ovulation, oocyte maturation","volume":"161","author":"Lim","year":"2021","journal-title":"Reproduction"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/19396368.2020.1754961","article-title":"The effect of low and ultra-low oxygen tensions on mammalian embryo culture and development in experimental and clinical IVF","volume":"66","author":"Belli","year":"2020","journal-title":"Syst. Biol. Reprod. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"106279","DOI":"10.1016\/j.anireprosci.2020.106279","article-title":"Oxygen tension during in vitro oocyte maturation and fertilization affects embryo quality in sheep and deer","volume":"213","author":"Ortiz","year":"2020","journal-title":"Anim. Reprod. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1098-2795(200012)57:4<353::AID-MRD7>3.0.CO;2-R","article-title":"Low oxygen tension during in vitro maturation is beneficial for supporting the subsequent development of bovine cumulus-oocyte complexes","volume":"57","author":"Hashimoto","year":"2000","journal-title":"Mol. Reprod. Dev."},{"key":"ref_158","unstructured":"He, H.H. (2020). Study on the Effect of Low Oxygen Concentration on Developmental Competence of Yak Oocyte Maturation, Pre-Implantation Embryos and Its Mechanisms. [Ph.D. Thesis, Gansu Agricultural University]."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/rda.14076","article-title":"Low oxygen concentration improves yak oocyte maturation and inhibits apoptosis through HIF-1 and VEGF","volume":"57","author":"He","year":"2022","journal-title":"Reprod. Domest. Anim."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.theriogenology.2020.06.022","article-title":"Low oxygen concentrations improve yak oocyte maturation and enhance the developmental competence of preimplantation embryos","volume":"156","author":"He","year":"2020","journal-title":"Theriogenology"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1017\/S0967199420000337","article-title":"Effects of oxygen concentrations on developmental competence and transcriptomic profile of yak oocytes","volume":"28","author":"Li","year":"2020","journal-title":"Zygote"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0093-691X(93)90390-Q","article-title":"Effect of epidermal growth factor (EGF) and defined simple media on in vitro bovine oocyte maturation and early embryonic development","volume":"39","author":"Park","year":"1993","journal-title":"Theriogenology"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1016\/j.theriogenology.2006.06.005","article-title":"Effect of angiotensin II with follicle cells and insulin-like growth factor-I or insulin on bovine oocyte maturation and embryo development","volume":"66","author":"Stefanello","year":"2006","journal-title":"Theriogenology"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/rda.12452","article-title":"Effects of FGF10 on bovine oocyte meiosis progression, apoptosis, embryo development and relative abundance of developmentally important genes in vitro","volume":"50","author":"Fontes","year":"2015","journal-title":"Reprod. Domest. Anim."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/mrd.22327","article-title":"Leukemia inhibitory factor enhances bovine oocyte maturation and early embryo development","volume":"81","author":"Mo","year":"2014","journal-title":"Mol. Reprod. Dev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1071\/RD21145","article-title":"Melatonin improves the maturation and developmental ability of bovine oocytes by up-regulating GJA4 to enhance gap junction intercellular communication","volume":"33","author":"Hao","year":"2021","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1439-0531.2004.00522.x","article-title":"Effect of alpha-tocopherol and ascorbic acid on bovine oocyte in vitro maturation","volume":"40","author":"Dalvit","year":"2005","journal-title":"Reprod. Domest. Anim."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1439-0531.2006.00770.x","article-title":"Bovine early embryonic development and vitamin A","volume":"41","author":"Facal","year":"2006","journal-title":"Reprod. Domest. Anim."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1530\/REP-19-0398","article-title":"Zinc supports transcription and improves meiotic competence of growing bovine oocytes","volume":"159","author":"Lodde","year":"2020","journal-title":"Reproduction"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0093-691X(01)00516-7","article-title":"The influence of cAMP before or during bovine oocyte maturation on embryonic developmental competence","volume":"55","author":"Guixue","year":"2001","journal-title":"Theriogenology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.anireprosci.2006.06.001","article-title":"Role of roscovitine and IBMX on kinetics of nuclear and cytoplasmic maturation of bovine oocytes in vitro","volume":"99","author":"Barretto","year":"2007","journal-title":"Anim. Reprod. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11626-016-0101-6","article-title":"Effect of C-type natriuretic peptide pretreatment on in vitro bovine oocyte maturation","volume":"53","author":"Zhang","year":"2017","journal-title":"In Vitro Cell Dev. Biol. Anim."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1071\/RD16474","article-title":"Differential effects of high and low glucose concentrations during lipolysis-like conditions on bovine in vitro oocyte quality, metabolism and subsequent embryo development","volume":"29","author":"Marei","year":"2017","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1071\/RD12125","article-title":"Effects of FSH on the expression of receptors for oocyte-secreted factors and members of the EGF-like family during in vitro maturation in cattle","volume":"25","author":"Caixeta","year":"2013","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0093-691X(02)01082-8","article-title":"Effect of 17beta-estradiol on the in vitro maturation of bovine oocytes","volume":"58","author":"Beker","year":"2002","journal-title":"Theriogenology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.theriogenology.2015.09.033","article-title":"The effect of temperature during liquid storage of in vitro-matured bovine oocytes on subsequent embryo development","volume":"85","author":"Suttirojpattana","year":"2016","journal-title":"Theriogenology"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.rbmo.2009.12.006","article-title":"Low oxygen tension during IVM improves bovine oocyte competence and enhances anaerobic glycolysis","volume":"20","author":"Lonergan","year":"2010","journal-title":"Reprod. Biomed. Online"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1071\/RD11080","article-title":"Differential glycolytic and glycogenogenic transduction pathways in male and female bovine embryos produced in vitro","volume":"24","author":"Aparicio","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Gutierrez-Reinoso, M.A., Aponte, P.M., and Garcia-Herreros, M. (2021). Genomic Analysis, Progress and Future Perspectives in Dairy Cattle Selection: A Review. Animals, 11.","DOI":"10.3390\/ani11030599"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1071\/RD17429","article-title":"Temporally differential protein expression of glycolytic and glycogenic enzymes during in vitro preimplantation bovine embryo development","volume":"30","author":"Simintiras","year":"2018","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1095\/biolreprod.110.087411","article-title":"Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation","volume":"84","author":"Aparicio","year":"2011","journal-title":"Biol. Reprod."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/10\/1882\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:59:56Z","timestamp":1760129996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/14\/10\/1882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":181,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["genes14101882"],"URL":"https:\/\/doi.org\/10.3390\/genes14101882","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]}}}