{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:55:37Z","timestamp":1791428137720,"version":"4.3.3"},"reference-count":74,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:00:00Z","timestamp":1696032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"University of Virginia and NIAID","doi-asserted-by":"publisher","award":["P01 AI150585"],"award-info":[{"award-number":["P01 AI150585"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Alternative RNA splicing, a ubiquitous mechanism of gene regulation in eukaryotes, expands genome coding capacity and proteomic diversity. It has essential roles in all aspects of human physiology, including immunity. This review highlights the importance of RNA alternative splicing in regulating immune T cell function. We discuss how mutations that affect the alternative splicing of T cell factors can contribute to abnormal T cell function and ultimately lead to autoimmune diseases. We also explore the potential applications of strategies that target the alternative splicing changes of T cell factors. These strategies could help design therapeutic approaches to treat autoimmune disorders and improve immunotherapy.<\/jats:p>","DOI":"10.3390\/genes14101896","type":"journal-article","created":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:58:09Z","timestamp":1696179489000},"page":"1896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Role of RNA Alternative Splicing in T Cell Function and Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Shefali","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22903, USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaddiel","family":"Galarza-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Autoimmmunity Biologic Solutions, Inc., K2bio, Houston, TX 77550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-1997","authenticated-orcid":false,"given":"Mariano A.","family":"Garcia-Blanco","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22903, USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.immuni.2018.01.007","article-title":"Human T Cell Development, Localization, and Function throughout Life","volume":"48","author":"Kumar","year":"2018","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: Implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. 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