{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:41:47Z","timestamp":1788633707135,"version":"build-2803163510"},"reference-count":73,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shandong Province Natural Science Foundation Joint Fund Project","award":["ZR2021LZY044"],"award-info":[{"award-number":["ZR2021LZY044"]}]},{"name":"Shandong Province Natural Science Foundation Joint Fund Project","award":["ZR2021MH373"],"award-info":[{"award-number":["ZR2021MH373"]}]},{"name":"Shandong Province Natural Science Foundation Joint Fund Project","award":["2020GXRC005"],"award-info":[{"award-number":["2020GXRC005"]}]},{"name":"Shandong Province Natural Science Foundation Joint Fund Project","award":["zyyzdxk-2023116"],"award-info":[{"award-number":["zyyzdxk-2023116"]}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021LZY044"],"award-info":[{"award-number":["ZR2021LZY044"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH373"],"award-info":[{"award-number":["ZR2021MH373"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["2020GXRC005"],"award-info":[{"award-number":["2020GXRC005"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["zyyzdxk-2023116"],"award-info":[{"award-number":["zyyzdxk-2023116"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jinan \u201cGaoXiao 20 Tiao\u201d Funding Project Contract","award":["ZR2021LZY044"],"award-info":[{"award-number":["ZR2021LZY044"]}]},{"name":"Jinan \u201cGaoXiao 20 Tiao\u201d Funding Project Contract","award":["ZR2021MH373"],"award-info":[{"award-number":["ZR2021MH373"]}]},{"name":"Jinan \u201cGaoXiao 20 Tiao\u201d Funding Project Contract","award":["2020GXRC005"],"award-info":[{"award-number":["2020GXRC005"]}]},{"name":"Jinan \u201cGaoXiao 20 Tiao\u201d Funding Project Contract","award":["zyyzdxk-2023116"],"award-info":[{"award-number":["zyyzdxk-2023116"]}]},{"name":"Qilu Health Leading Talent Project","award":["ZR2021LZY044"],"award-info":[{"award-number":["ZR2021LZY044"]}]},{"name":"Qilu Health Leading Talent Project","award":["ZR2021MH373"],"award-info":[{"award-number":["ZR2021MH373"]}]},{"name":"Qilu Health Leading Talent Project","award":["2020GXRC005"],"award-info":[{"award-number":["2020GXRC005"]}]},{"name":"Qilu Health Leading Talent Project","award":["zyyzdxk-2023116"],"award-info":[{"award-number":["zyyzdxk-2023116"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Globally, oral diseases are common, pose an economic burden, and significantly decline the quality of life of affected individuals. Recently, researchers have substantially highlighted the effect of depression on oral disease incidence and development. In this study, we elucidated the correlation between depression and oral diseases. Methods: Using two-sample Mendelian randomization (MR), the association between depression and the risk of 17 oral diseases was evaluated. Three methods were used to perform MR analysis: the inverse variance-weighted, weighted median, and MR-Egger methods. Furthermore, Cochran\u2019s Q test, MR-Egger intercept test, MR Pleiotropy RESidual Sum and Outlier test, and leave-one-out analysis were performed to analyze sensitivity. Results: After implementing multiple test corrections, we observed that genetic susceptibility to depression was associated with an increased risk of mouth ulcers, toothache, loose teeth, bleeding gums, painful gums, chronic periodontitis, chronic tonsil and adenoid diseases, peritonsillar abscess, and excessive tooth attrition. However, a causal relationship between depression and other oral diseases was not observed. Sensitivity analysis confirmed the robustness of the results. Conclusions: We confirmed the causal relationship between depression and several oral diseases, thereby providing a novel viewpoint on the prevention and treatment of oral diseases. Our findings suggest the integration of depression control into routine clinical care to enhance the effectiveness of oral disease treatment.<\/jats:p>","DOI":"10.3390\/genes14122191","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:56:00Z","timestamp":1702277760000},"page":"2191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Potential Causal Association between Depression and Oral Diseases: A Mendelian Randomization Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaobin","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Acupuncture, Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehe","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3718-7588","authenticated-orcid":false,"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengzhen","family":"Xing","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Acupuncture, Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dobrek, L., and G\u0142owacka, K. 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