{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:55:40Z","timestamp":1773096940866,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Governor\u2019s Special Program of 2023","award":["Yuecainong [2023] No. 145"],"award-info":[{"award-number":["Yuecainong [2023] No. 145"]}]},{"name":"The Governor\u2019s Special Program of 2023","award":["R2020PY-JX001"],"award-info":[{"award-number":["R2020PY-JX001"]}]},{"name":"The Governor\u2019s Special Program of 2023","award":["2023B1212060042"],"award-info":[{"award-number":["2023B1212060042"]}]},{"name":"The Special Fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agricultural Science","award":["Yuecainong [2023] No. 145"],"award-info":[{"award-number":["Yuecainong [2023] No. 145"]}]},{"name":"The Special Fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agricultural Science","award":["R2020PY-JX001"],"award-info":[{"award-number":["R2020PY-JX001"]}]},{"name":"The Special Fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agricultural Science","award":["2023B1212060042"],"award-info":[{"award-number":["2023B1212060042"]}]},{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding","award":["Yuecainong [2023] No. 145"],"award-info":[{"award-number":["Yuecainong [2023] No. 145"]}]},{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding","award":["R2020PY-JX001"],"award-info":[{"award-number":["R2020PY-JX001"]}]},{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding","award":["2023B1212060042"],"award-info":[{"award-number":["2023B1212060042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Rice blast disease, caused by the fungal pathogen Magnaporthe oryzae, is a major threat to rice production worldwide. This study investigates the role of long non-coding RNAs (lncRNAs) in rice\u2019s response to this destructive disease, with a focus on their impacts on disease resistance and yield traits. Three specific lncRNAs coded by M. oryzae infection-responsive lncRNAs (MOIRAs), MOIRA1, MOIRA2, and MOIRA3, were identified as key regulators of rice\u2019s response to M. oryzae infection. Strikingly, when MOIRA1 and MOIRA2 were overexpressed, they exhibited a dual function: they increased rice\u2019s susceptibility to blast fungus, indicating a negative role in disease resistance, while simultaneously enhancing tiller numbers and single-plant yield, with no adverse effects on other yield-related traits. This unexpected improvement in productivity suggests the possibility of overcoming the traditional trade-off between disease resistance and crop yield. These findings provide a novel perspective on crop enhancement, offering a promising solution to global food security challenges by developing rice varieties that effectively balance disease resistance and increased productivity.<\/jats:p>","DOI":"10.3390\/genes15010082","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:38:51Z","timestamp":1704775131000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Unveiling the Roles of LncRNA MOIRAs in Rice Blast Disease Resistance"],"prefix":"10.3390","volume":"15","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding, Guangdong Rice Engineering Laboratory, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory for Crop Germplasm Resources Preservation and Utilization, Agro-Biological Gene Research Center, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding, Guangdong Rice Engineering Laboratory, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding, Guangdong Rice Engineering Laboratory, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of New Technology in Rice Breeding, Guangdong Rice Engineering Laboratory, Key Laboratory of Genetics and Breeding of High Quality Rice in Southern China (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Rice Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1126\/science.1171663","article-title":"Coevolution of plants and their pathogens in natural habitats","volume":"324","author":"Burdon","year":"2009","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11427-020-1699-4","article-title":"The genetic arms race between plant and Xanthomonas: Lessons learned from TALE biology","volume":"64","author":"Xue","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Asibi, A.E., Chai, Q., and Coulter, J.A. (2019). Rice blast: A disease with implications for global food security. Agronomy, 9.","DOI":"10.3390\/agronomy9080451"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s42994-023-00099-4","article-title":"The Phantom Menace: Latest findings on effector biology in the rice blast fungus","volume":"4","author":"Fernandez","year":"2023","journal-title":"aBIOTECH"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/07388551.2017.1312270","article-title":"Emerging roles of long non-coding RNAs in plant response to biotic and abiotic stresses","volume":"38","author":"Nejat","year":"2018","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhang, H., Guo, H., Hu, W., and Ji, W. (2020). The emerging role of long non-coding RNAs in plant defense against fungal stress. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21082659"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yang, Y., Liu, T., Shen, D., Wang, J., Ling, X., Hu, Z., Chen, T., Hu, J., Huang, J., and Yu, W. (2019). Tomato yellow leaf curl virus intergenic siRNAs target a host long noncoding RNA to modulate disease symptoms. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007534"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100180","DOI":"10.1016\/j.xplc.2021.100180","article-title":"Role of non-coding RNAs in plant immunity","volume":"2","author":"Song","year":"2021","journal-title":"Plant Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s42994-023-00100-0","article-title":"Shining in the dark: The big world of small peptides in plants","volume":"4","author":"Feng","year":"2023","journal-title":"aBIOTECH"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"He, H., Zhou, Y.-F., Yang, Y.-W., Zhang, Z., Lei, M.-Q., Feng, Y.-Z., Zhang, Y.-C., Chen, Y.-Q., Lian, J.-P., and Yu, Y. (2021). Genome-Wide Analysis Identified a Set of Conserved lncRNAs Associated with Domestication-Related Traits in Rice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094742"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-cellbio-100818-125218","article-title":"Plant noncoding RNAs: Hidden players in development and stress responses","volume":"35","author":"Yu","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wu, L., Liu, S., Qi, H., Cai, H., and Xu, M. (2020). Research progress on plant long non-coding RNA. Plants, 9.","DOI":"10.3390\/plants9040408"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev-arplant-093020-035446","article-title":"Long noncoding RNAs in plants","volume":"72","author":"Wierzbicki","year":"2021","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.chom.2022.07.001","article-title":"A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth","volume":"30","author":"Liu","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/tpj.14847","article-title":"Sl-lncRNA15492 interacts with Sl-miR482a and affects Solanum lycopersicum immunity against Phytophthora infestans","volume":"103","author":"Jiang","year":"2020","journal-title":"Plant J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41438-018-0096-0","article-title":"Tomato lncRNA23468 functions as a competing endogenous RNA to modulate NBS-LRR genes by decoying miR482b in the tomato-Phytophthora infestans interaction","volume":"6","author":"Jiang","year":"2019","journal-title":"Hortic. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"634819","DOI":"10.3389\/fpls.2020.634819","article-title":"Bacillus subtilis SL18r Induces Tomato Resistance Against Botrytis cinerea, Involving Activation of Long Non-coding RNA, MSTRG18363, to Decoy miR1918","volume":"11","author":"Zhou","year":"2021","journal-title":"Front Plant Sci"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/pbi.12861","article-title":"Long noncoding RNAs involve in resistance to Verticillium dahliae, a fungal disease in cotton","volume":"16","author":"Zhang","year":"2018","journal-title":"Plant Biotechnol. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12284-020-00437-w","article-title":"Long Non-coding RNAs Responsive to Blast Fungus Infection in Rice","volume":"13","author":"Wang","year":"2020","journal-title":"Rice"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.6026\/97320630013249","article-title":"Identification of long non-coding RNA in rice lines resistant to Rice blast pathogen Maganaporthe oryzae","volume":"13","author":"Jain","year":"2017","journal-title":"Bioinformation"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Choi, G., Jeon, J., Lee, H., Zhou, S., and Lee, Y.-H. (2022). Genome-wide profiling of long non-coding RNA of the rice blast fungus Magnaporthe oryzae during infection. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08380-4"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/jipb.13175","article-title":"Tangeretin inhibits fungal ferroptosis to suppress rice blast","volume":"63","author":"Liang","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"ref_23","first-page":"43","article-title":"Integrating small RNA sequencing with QTL mapping for identification of miRNAs and their target genes associated with heat tolerance at the flowering stage in rice","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Plant Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/pbi.13234","article-title":"Transcriptional landscape of pathogen-responsive lncRNAs in rice unveils the role of ALEX1 in jasmonate pathway and disease resistance","volume":"18","author":"Yu","year":"2020","journal-title":"Plant Biotechnol. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Datta, R., and Paul, S. (2019). Long non-coding RNAs: Fine-tuning the developmental responses in plants. J. Biosci., 44.","DOI":"10.1007\/s12038-019-9910-6"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tplants.2015.03.003","article-title":"Battles and hijacks: Noncoding transcription in plants","volume":"20","author":"Ariel","year":"2015","journal-title":"Trends Plant Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Waititu, J.K., Zhang, C., Liu, J., and Wang, H. (2020). Plant non-coding RNAs: Origin, biogenesis, mode of action and their roles in abiotic stress. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218401"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.tplants.2017.09.010","article-title":"Balancing immunity and yield in crop plants","volume":"22","author":"Ning","year":"2017","journal-title":"Trends Plant Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.3389\/fpls.2018.01999","article-title":"miR396-OsGRF s module balances growth and rice blast disease-resistance","volume":"9","author":"Chandran","year":"2019","journal-title":"Front. Plant Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12284-021-00529-1","article-title":"Rice miR1432 fine-tunes the balance of yield and blast disease resistance via different modules","volume":"14","author":"Li","year":"2021","journal-title":"Rice"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Xiao, N., Pan, C., Li, Y., Wu, Y., Cai, Y., Lu, Y., Wang, R., Yu, L., Shi, W., and Kang, H. (2021). Genomic insight into balancing high yield, good quality, and blast resistance of japonica rice. Genome Biol., 22.","DOI":"10.1186\/s13059-021-02488-8"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhu, Q., Feng, Y., Xue, J., Chen, P., Zhang, A., and Yu, Y. (2023). Advances in Receptor-like Protein Kinases in Balancing Plant Growth and Stress Responses. Plants, 12.","DOI":"10.3390\/plants12030427"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/1\/82\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:42:40Z","timestamp":1760103760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/1\/82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["genes15010082"],"URL":"https:\/\/doi.org\/10.3390\/genes15010082","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}