{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:59:52Z","timestamp":1769914792986,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds de la Recherche en Sant\u00e9 du Qu\u00e9bec (FRSQ)","award":["CIHR #PJT 153287"],"award-info":[{"award-number":["CIHR #PJT 153287"]}]},{"name":"Fonds de la Recherche en Sant\u00e9 du Qu\u00e9bec (FRSQ)","award":["PJT 178210"],"award-info":[{"award-number":["PJT 178210"]}]},{"name":"Canadian Institute for Health Research","award":["CIHR #PJT 153287"],"award-info":[{"award-number":["CIHR #PJT 153287"]}]},{"name":"Canadian Institute for Health Research","award":["PJT 178210"],"award-info":[{"award-number":["PJT 178210"]}]},{"name":"National Research Council of Canada (NSERC)","award":["CIHR #PJT 153287"],"award-info":[{"award-number":["CIHR #PJT 153287"]}]},{"name":"National Research Council of Canada (NSERC)","award":["PJT 178210"],"award-info":[{"award-number":["PJT 178210"]}]},{"name":"J.L. Levesque Foundation","award":["CIHR #PJT 153287"],"award-info":[{"award-number":["CIHR #PJT 153287"]}]},{"name":"J.L. Levesque Foundation","award":["PJT 178210"],"award-info":[{"award-number":["PJT 178210"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The e4 allele of the apolipoprotein E gene is the strongest genetic risk factor for sporadic Alzheimer\u2019s disease. Nevertheless, how APOE is regulated is still elusive. In a trans-eQTL analysis, we found a genome-wide significant association between transmembrane protein 106B (TMEM106B) genetic variants and cortical APOE mRNA levels in human brains. The goal of this study is to determine whether TMEM106B is mis-regulated in Alzheimer\u2019s disease or in other neurodegenerative conditions. Available genomic, transcriptomic and proteomic data from human brains were downloaded from the Mayo Clinic Brain Bank and the Religious Orders Study and Memory and Aging Project. An in-house mouse model of the hippocampal deafferentation\/reinnervation was achieved via a stereotaxic lesioning surgery to the entorhinal cortex, and mRNA levels were measured using RNAseq technology. In human temporal cortices, the mean TMEM106B expression was significantly higher in Alzheimer\u2019s disease compared to cognitively unimpaired individuals. In the mouse model, hippocampal Tmem106b reached maximum levels during the early phase of reinnervation. These results suggest an active response to tissue damage that is consistent with compensatory synaptic and terminal remodeling.<\/jats:p>","DOI":"10.3390\/genes15040416","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:16:41Z","timestamp":1711459001000},"page":"416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1107-6839","authenticated-orcid":false,"given":"Cynthia","family":"Picard","sequence":"first","affiliation":[{"name":"Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada"},{"name":"Centre for the Studies on Prevention of Alzheimer\u2019s Disease, Montreal, QC H4H 1R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Miron","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada"},{"name":"Centre for the Studies on Prevention of Alzheimer\u2019s Disease, Montreal, QC H4H 1R3, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC H3A 0E7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8018-4545","authenticated-orcid":false,"given":"Judes","family":"Poirier","sequence":"additional","affiliation":[{"name":"Douglas Mental Health University Institute, Montreal, QC H4H 1R3, Canada"},{"name":"Centre for the Studies on Prevention of Alzheimer\u2019s Disease, Montreal, QC H4H 1R3, Canada"},{"name":"Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, QC H3A 0E7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer\u2019s disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. 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