{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:24:12Z","timestamp":1762658652746,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007064","name":"University of Ja\u00e9n","doi-asserted-by":"publisher","award":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"],"award-info":[{"award-number":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"]}],"id":[{"id":"10.13039\/501100007064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"],"award-info":[{"award-number":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Innovation, the State Research Agency (AEI), and the European Regional Development Fund","award":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"],"award-info":[{"award-number":["PAIUJA-EI_CTS02_2023","BIO-302","PID2021-122991NB-C21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Uterine pathologies pose a challenge to women\u2019s health on a global scale. Despite extensive research, the causes and origin of some of these common disorders are not well defined yet. This study presents a comprehensive analysis of transcriptome data from diverse datasets encompassing relevant uterine pathologies such as endometriosis, endometrial cancer and uterine leiomyomas. Leveraging the Comparative Analysis of Shapley values (CASh) technique, we demonstrate its efficacy in improving the outcomes of the classical differential expression analysis on transcriptomic data derived from microarray experiments. CASh integrates the microarray game algorithm with Bootstrap resampling, offering a robust statistical framework to mitigate the impact of potential outliers in the expression data. Our findings unveil novel insights into the molecular signatures underlying these gynecological disorders, highlighting CASh as a valuable tool for enhancing the precision of transcriptomics analyses in complex biological contexts. This research contributes to a deeper understanding of gene expression patterns and potential biomarkers associated with these pathologies, offering implications for future diagnostic and therapeutic strategies.<\/jats:p>","DOI":"10.3390\/genes15060723","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T10:08:38Z","timestamp":1717409318000},"page":"723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Analysis of Shapley Values Enhances Transcriptomics Insights across Some Common Uterine Pathologies"],"prefix":"10.3390","volume":"15","author":[{"given":"Jos\u00e9 A.","family":"Castro-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-8518","authenticated-orcid":false,"given":"Eva","family":"Vargas","sequence":"additional","affiliation":[{"name":"Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6726-9456","authenticated-orcid":false,"given":"Leticia","family":"D\u00edaz-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"},{"name":"Clinical Research Unit, Department of Medical Oncology, University Hospital of Ja\u00e9n, 23007 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-2973","authenticated-orcid":false,"given":"Francisco J.","family":"Esteban","sequence":"additional","affiliation":[{"name":"Systems Biology Unit, Department of Experimental Biology, Faculty of Experimental Sciences, University of Ja\u00e9n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.fertnstert.2020.01.025","article-title":"Uterine disorders affecting female fertility: What are the molecular functions altered in endometrium?","volume":"113","author":"Arnau","year":"2020","journal-title":"Fertil. 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