{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:39:07Z","timestamp":1786685947093,"version":"build-2736575974"},"reference-count":52,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lipedema Foundation","award":["LF#31"],"award-info":[{"award-number":["LF#31"]}]},{"name":"Lipedema Foundation","award":["HL158801"],"award-info":[{"award-number":["HL158801"]}]},{"name":"Lipedema Foundation","award":["AHA 24POST1191727"],"award-info":[{"award-number":["AHA 24POST1191727"]}]},{"name":"Lipedema Foundation","award":["P01HL160470-01A1"],"award-info":[{"award-number":["P01HL160470-01A1"]}]},{"name":"donation from Mr. David Bradley","award":["LF#31"],"award-info":[{"award-number":["LF#31"]}]},{"name":"donation from Mr. David Bradley","award":["HL158801"],"award-info":[{"award-number":["HL158801"]}]},{"name":"donation from Mr. David Bradley","award":["AHA 24POST1191727"],"award-info":[{"award-number":["AHA 24POST1191727"]}]},{"name":"donation from Mr. David Bradley","award":["P01HL160470-01A1"],"award-info":[{"award-number":["P01HL160470-01A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Lipedema and lymphedema are physically similar yet distinct diseases that are commonly misdiagnosed. We previously reported that lipedema and lymphedema are associated with increased risk for venous thromboembolism (VTE). The underlying etiology of the prothrombotic profile observed in lipedema and lymphedema is unclear, but may be related to alterations in platelets. Our objective was to analyze the platelet transcriptome to identify biological pathways that may provide insight into platelet activation and thrombosis. The platelet transcriptome was evaluated in patients with lymphedema and lipedema, then compared to control subjects with obesity. Patients with lipedema were found to have a divergent transcriptome from patients with lymphedema. The platelet transcriptome and impacted biological pathways in lipedema were surprisingly similar to weight-matched comparators, yet different when compared to overweight individuals with a lower body mass index (BMI). Differences in the platelet transcriptome for patients with lipedema and lymphedema were found in biological pathways required for protein synthesis and degradation, as well as metabolism. Key differences in the platelet transcriptome for patients with lipedema compared to BMI-matched subjects involved metabolism and glycosaminoglycan processing. These inherent differences in the platelet transcriptome warrant further investigation, and may contribute to the increased risk of thrombosis in patients with lipedema and lymphedema.<\/jats:p>","DOI":"10.3390\/genes15060737","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:43:54Z","timestamp":1717577034000},"page":"737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Divergent Platelet Transcriptome in Patients with Lipedema and Lymphedema"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3743-4366","authenticated-orcid":false,"given":"Alliefair","family":"Scalise","sequence":"first","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Department of Cardiovascular Medicine, Section of Vascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseer","family":"Sangwan","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelise","family":"Hamer","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Department of Cardiovascular Medicine, Section of Vascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Guntupalli","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun Edelyn","family":"Park","sequence":"additional","affiliation":[{"name":"Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3753-6717","authenticated-orcid":false,"given":"Jose O.","family":"Aleman","sequence":"additional","affiliation":[{"name":"Holman Division of Endocrinology, New York University, New York, NY 10012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-1540","authenticated-orcid":false,"given":"Scott J.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Department of Cardiovascular Medicine, Section of Vascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"},{"name":"Lerner Research Institute, Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Foundation, Cleveland, OH 44195, USA"},{"name":"Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA"},{"name":"Department of Hematology, Taussig Cancer Center, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1177\/0268355520938283","article-title":"Diagnostic approach to lower limb edema","volume":"35","author":"Gasparis","year":"2020","journal-title":"Phlebology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1177\/1358863X231202769","article-title":"National survey of patient symptoms and therapies among 707 women with a lipedema phenotype in the United States","volume":"29","author":"Aday","year":"2024","journal-title":"Vasc. 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