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Kirschstein National Service Award","doi-asserted-by":"publisher","award":["5295"],"award-info":[{"award-number":["5295"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drugs of Abuse (NIDA) Ruth L. Kirschstein National Service Award","doi-asserted-by":"publisher","award":["2020"],"award-info":[{"award-number":["2020"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drugs of Abuse (NIDA) Ruth L. Kirschstein National Service Award","doi-asserted-by":"publisher","award":["2022-67011-36461"],"award-info":[{"award-number":["2022-67011-36461"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drugs of Abuse (NIDA) Ruth L. Kirschstein National Service Award","doi-asserted-by":"publisher","award":["T32DK120509"],"award-info":[{"award-number":["T32DK120509"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drugs of Abuse (NIDA) Ruth L. Kirschstein National Service Award","doi-asserted-by":"publisher","award":["F30DA057094"],"award-info":[{"award-number":["F30DA057094"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Infant consumption of human milk (HM) is associated with a reduced risk of overweight and obesity, but the reasons for this relationship are not completely understood. There is emerging evidence that micro RNAs (miRNAs) regulate infant development and metabolism, but the associations between HM miRNAs and infant growth remain poorly understood. We examined the relationship between HM miRNA consumption and infant obesity in 163 mother\u2013infant dyads to determine (1) if miRNA profiles differentiate infants with obesity, and (2) if individual miRNAs accurately predicted infant obesity status at one year of age. Infant obesity was categorized as weight-for-length (WFL) Z scores or conditional weight gain (CWG) in the 95th percentile. HM miRNA profile was associated with infant age (r2 = 6.4%, p = 0.001), but not maternal obesity status (r2 = 1.5%, p = 0.87) or infant weight status (WFL Z-score) at birth (r2 = 0.6%, p = 0.4), 1 month (r2 = 0.5%, p = 0.6), or 4 months (r2 = 0.8%, p = 0.2). Nine HM miRNAs were associated with either 12-month CWG or 12-month WFL Z scores. Among these 9 miRNAs, miR-224-5p remained significant in a logistic regression model that accounted for additional demographic factors (estimate = \u221227.57, p = 0.004). These findings suggest involvement of HM miRNAs and particularly miR-224-5p in infant growth, warranting further investigation. To our knowledge, this is the largest study of HM miRNAs and early-life obesity and contributes to the understanding of the relationship between HM miRNAs and infant growth.<\/jats:p>","DOI":"10.3390\/genes15060813","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T05:27:19Z","timestamp":1718861239000},"page":"813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of Maternal Breastmilk microRNAs and Infant Obesity Status at 1 Year"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-534X","authenticated-orcid":false,"given":"Emily","family":"Van Syoc","sequence":"first","affiliation":[{"name":"Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA"},{"name":"One Health Microbiome Center, The Pennsylvania State University, University Park, PA 16801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Stegman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0725-6386","authenticated-orcid":false,"given":"Rhea","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Confair","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"},{"name":"Department of Emergency Medicine, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9579-6798","authenticated-orcid":false,"given":"Steven D.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990\u20132019: A systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"Murray","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1001\/jama.2009.761","article-title":"Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood","volume":"301","author":"Leunissen","year":"2009","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000496563","article-title":"Prediction Models for Early Childhood Obesity: Applicability and Existing Issues","volume":"90","author":"Butler","year":"2018","journal-title":"Horm. 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