{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:14:46Z","timestamp":1785924886841,"version":"3.56.0"},"reference-count":79,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria","award":["INIA_CL_40"],"award-info":[{"award-number":["INIA_CL_40"]}]},{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria","award":["INIA_CL_38"],"award-info":[{"award-number":["INIA_CL_38"]}]},{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria","award":["CSIC_I+D_2018_287"],"award-info":[{"award-number":["CSIC_I+D_2018_287"]}]},{"name":"Instituto Nacional de Investigaci\u00f3n Agropecuaria","award":["772787"],"award-info":[{"award-number":["772787"]}]},{"name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica, CSIC, Universidad de la Rep\u00fablica","award":["INIA_CL_40"],"award-info":[{"award-number":["INIA_CL_40"]}]},{"name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica, CSIC, Universidad de la Rep\u00fablica","award":["INIA_CL_38"],"award-info":[{"award-number":["INIA_CL_38"]}]},{"name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica, CSIC, Universidad de la Rep\u00fablica","award":["CSIC_I+D_2018_287"],"award-info":[{"award-number":["CSIC_I+D_2018_287"]}]},{"name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica, CSIC, Universidad de la Rep\u00fablica","award":["772787"],"award-info":[{"award-number":["772787"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["INIA_CL_40"],"award-info":[{"award-number":["INIA_CL_40"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["INIA_CL_38"],"award-info":[{"award-number":["INIA_CL_38"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["CSIC_I+D_2018_287"],"award-info":[{"award-number":["CSIC_I+D_2018_287"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["772787"],"award-info":[{"award-number":["772787"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>The objective of this study was to identify genomic regions and genes associated with resistance to gastrointestinal nematodes in Australian Merino sheep in Uruguay, using the single-step GWAS methodology (ssGWAS), which is based on genomic estimated breeding values (GEBVs) obtained from a combination of pedigree, genomic, and phenotypic data. This methodology converts GEBVs into SNP effects. The analysis included 26,638 animals with fecal egg count (FEC) records obtained in two independent parasitic cycles (FEC1 and FEC2) and 1700 50K SNP genotypes. The comparison of genomic regions was based on genetic variances (gVar(%)) explained by non-overlapping regions of 20 SNPs. For FEC1 and FEC2, 18 and 22 genomic windows exceeded the significance threshold (gVar(%) \u2265 0.22%), respectively. The genomic regions with strong associations with FEC1 were located on chromosomes OAR 2, 6, 11, 21, and 25, and for FEC2 on OAR 5, 6, and 11. The proportion of genetic variance attributed to the top windows was 0.83% and 1.9% for FEC1 and FEC2, respectively. The 33 candidate genes shared between the two traits were subjected to enrichment analysis, revealing a marked enrichment in biological processes related to immune system functions. These results contribute to the understanding of the genetics underlying gastrointestinal parasite resistance and its implications for other productive and welfare traits in animal breeding programs.<\/jats:p>","DOI":"10.3390\/genes15070846","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:42:30Z","timestamp":1719546150000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genomic Regions Associated with Resistance to Gastrointestinal Parasites in Australian Merino Sheep"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8200-4117","authenticated-orcid":false,"given":"Brenda","family":"Vera","sequence":"first","affiliation":[{"name":"Sistema Ganadero Extensivo, INIA Las Brujas, Canelones 90200, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elly A.","family":"Navajas","sequence":"additional","affiliation":[{"name":"Sistema Ganadero Extensivo, INIA Las Brujas, Canelones 90200, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Peraza","sequence":"additional","affiliation":[{"name":"Sistema Ganadero Extensivo, INIA Las Brujas, Canelones 90200, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-367X","authenticated-orcid":false,"given":"Beatriz","family":"Carracelas","sequence":"additional","affiliation":[{"name":"Sistema Ganadero Extensivo, INIA Las Brujas, Canelones 90200, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-0456","authenticated-orcid":false,"given":"Elize","family":"Van Lier","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Animal y Pasturas, Facultad de Agronom\u00eda, Universidad de la Rep\u00fablica, Avda. Garz\u00f3n 780, Montevideo 12900, Uruguay"},{"name":"Estaci\u00f3n Experimental Facultad de Agronom\u00eda Salto, Salto 50000, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-3956","authenticated-orcid":false,"given":"Gabriel","family":"Ciappesoni","sequence":"additional","affiliation":[{"name":"Sistema Ganadero Extensivo, INIA Las Brujas, Canelones 90200, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cvfa.2006.07.006","article-title":"Gastrointestinal Nematodes of Small Ruminants: Life Cycle, Anthelmintics, and Diagnosis","volume":"22","author":"Zajac","year":"2006","journal-title":"Vet. Clin. N. Am. Food Anim. 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