{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:14:50Z","timestamp":1761948890042,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Genomic Medicine","award":["13\/2019\/I","FOSISS A3-S-45155","CVU:1002577"],"award-info":[{"award-number":["13\/2019\/I","FOSISS A3-S-45155","CVU:1002577"]}]},{"name":"Consejo Nacional de Humanidades, Ciencia y Tecnolog\u00eda","award":["13\/2019\/I","FOSISS A3-S-45155","CVU:1002577"],"award-info":[{"award-number":["13\/2019\/I","FOSISS A3-S-45155","CVU:1002577"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Current therapy in chronic myeloid leukemia (CML) has improved patient life expectancy close to that of healthy individuals. However, molecular alterations other than BCR::ABL1 fusion gene in CML are barely known. MicroRNAs are important regulators of gene expression, and variants in some of the components of microRNA biosynthesis pathways have been associated with genetic susceptibility to different types of cancer. Thus, the aim of this study was to evaluate the association of variants located in genes involved in the biogenesis of microRNAs with susceptibility to CML. Fifteen variants in eight genes involved in the biogenesis of miRNAs were genotyped in 296 individuals with CML and 485 healthy participants using TaqMan probes. The association of gene variants with CML and clinical variables was evaluated by a Chi-square test, and odds ratios and 95% confidence intervals were estimated by logistic regression. The variant rs13078 in DICER1 was significantly higher among CML individuals than in healthy participants. In addition, the variants rs7813 and rs2740349 were significantly associated with worse prognosis, according to their Hasford scores, whereas the rs2740349 variant was also associated with a later age at diagnosis. These findings suggest that variants in components of the microRNA biogenesis pathway could be involved in CML genetic risk.<\/jats:p>","DOI":"10.3390\/genes15081054","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T05:19:38Z","timestamp":1723439978000},"page":"1054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gene Variants in Components of the microRNA Processing Pathway in Chronic Myeloid Leukemia"],"prefix":"10.3390","volume":"15","author":[{"given":"Guillermina","family":"Chavaro-Francisco","sequence":"first","affiliation":[{"name":"Section of Research and Postgraduate Studies, Superior School of Medicine, National Institute Polytechique, Mexico City 11340, Mexico"},{"name":"Oncogenomics Consortium Laboratory, Clinic Research Department, National Institute of Genomic Medicine, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Hern\u00e1ndez-Zavala","sequence":"additional","affiliation":[{"name":"Section of Research and Postgraduate Studies, Superior School of Medicine, National Institute Polytechique, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila E.","family":"Bravo-Cidro","sequence":"additional","affiliation":[{"name":"Oncogenomics Consortium Laboratory, Clinic Research Department, National Institute of Genomic Medicine, Mexico City 14610, Mexico"},{"name":"Department of Biological Systems, Metropolitan Autonomous University, Campus Xochimilco, Mexico City 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandybel","family":"Rios-Rodriguez","sequence":"additional","affiliation":[{"name":"Oncogenomics Consortium Laboratory, Clinic Research Department, National Institute of Genomic Medicine, Mexico City 14610, Mexico"},{"name":"Department of Biological Systems, Metropolitan Autonomous University, Campus Xochimilco, Mexico City 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Muci\u00f1o-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Oncogenomics Consortium Laboratory, Clinic Research Department, National Institute of Genomic Medicine, Mexico City 14610, Mexico"},{"name":"School of Biology, Metropolitan Autonomous University, Campus Xochimilco, Mexico City 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-8052","authenticated-orcid":false,"given":"Marisol","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Biological Systems, Metropolitan Autonomous University, Campus Xochimilco, Mexico City 04960, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9239-6481","authenticated-orcid":false,"given":"X\u00f3chitl H.","family":"Castro-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Genomics of Psychiatric and Neurogenerative Diseases Laboratory, National Institute of Genomic Medicine, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Olarte-Carrillo","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Service of Hematology, Hospital General de Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anel","family":"Garcia-Laguna","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Service of Hematology, Hospital General de Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2988-7544","authenticated-orcid":false,"given":"Gilberto","family":"Barranco-Lamp\u00f3n","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Service of Hematology, Hospital General de Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"De la Cruz-Rosas","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Service of Hematology, Hospital General de Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-3731","authenticated-orcid":false,"given":"Adolfo","family":"Mart\u00ednez-Tovar","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory, Service of Hematology, Hospital General de Mexico, \u201cDr. Eduardo Liceaga\u201d, Mexico City 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio J.","family":"C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Oncogenomics Consortium Laboratory, Clinic Research Department, National Institute of Genomic Medicine, Mexico City 14610, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100825","DOI":"10.1016\/j.blre.2021.100825","article-title":"Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions","volume":"49","author":"Osman","year":"2021","journal-title":"Blood Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/s41375-019-0562-1","article-title":"Chronic myeloid leukemia: The concepts of resistance and persistence and the relationship with the BCR-ABL1 transcript type","volume":"33","author":"Baccarani","year":"2019","journal-title":"Leukemia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1056\/NEJMoa022457","article-title":"Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia","volume":"348","author":"Guilhot","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101196","DOI":"10.1016\/j.blre.2024.101196","article-title":"Chronic myeloid leukaemia: Biology and therapy","volume":"65","author":"Wang","year":"2024","journal-title":"Blood Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1200\/JCO.2015.66.2866","article-title":"Life Expectancy of Patients with Chronic Myeloid Leukemia Approaches the Life Expectancy of the General Population","volume":"34","author":"Bower","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"580759","DOI":"10.3389\/fonc.2020.580759","article-title":"Global, Regional, and National Burden of Chronic Myeloid Leukemia, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"10","author":"Lin","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1158\/1055-9965.EPI-13-0093","article-title":"Lifestyle and Dietary Factors in Relation to Risk of Chronic Myeloid Leukemia in the NIH-AARP Diet and Health Study","volume":"22","author":"Kabat","year":"2013","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"003","DOI":"10.1055\/s-0034-1397344","article-title":"Overview of MicroRNA Biology","volume":"35","author":"Mohr","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fu, Z., Wang, L., Li, S., Chen, F., Au-Yeung, K.K.-W., and Shi, C. (2021). MicroRNA as an Important Target for Anticancer Drug Development. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.736323"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: From microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s12015-018-9808-y","article-title":"Cell Cycle Regulation of Stem Cells by MicroRNAs","volume":"14","author":"Mens","year":"2018","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41420-018-0089-7","article-title":"Downregulated circulating microRNAs after surgery: Potential noninvasive biomarkers for diagnosis and prognosis of early breast cancer","volume":"4","author":"Wang","year":"2018","journal-title":"Cell Death Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/s11605-010-1202-2","article-title":"Altered Expression of MiR-148a and MiR-152 in Gastrointestinal Cancers and Its Clinical Significance","volume":"14","author":"Chen","year":"2010","journal-title":"J. Gastrointest. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.7150\/ijbs.7.567","article-title":"miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells","volume":"7","author":"Guo","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e2503","DOI":"10.1038\/cddis.2016.373","article-title":"miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3\/AKT2\/c-myc and DNMT1 in bladder cancer","volume":"7","author":"Wang","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.1038\/s41467-021-26420-7","article-title":"Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Martins, J.R.B., Moraes, L.N., Cury, S.S., Capannacci, J., Carvalho, R.F., Nogueira, C.R., Hokama, N.K., and Hokama, P.O.M. (2021). MiR-125a-3p and MiR-320b Differentially Expressed in Patients with Chronic Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation and Imatinib Mesylate. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910216"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41419-021-04209-2","article-title":"Aberrantly reduced expression of miR-342-5p contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistance","volume":"12","author":"Wu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"O\u2019Brien, J., Hayder, H., Zayed, Y., and Peng, C. (2018). Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00402"},{"key":"ref_21","first-page":"1341","article-title":"Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers","volume":"44","author":"Sung","year":"2015","journal-title":"Leuk. Res."},{"key":"ref_22","first-page":"1235","article-title":"Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma","volume":"26","author":"Heidari","year":"2019","journal-title":"Pathol. Oncol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Basak, J., Piotrzkowska, D., Majsterek, I., and Kucharska, E. (2022). Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10123124"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Wen, Z., Zou, X., Xie, X., Zheng, S., Chen, X., Zhu, K., Dong, S., Liang, J., Huang, X., and Liu, D. (2019). Association of Polymorphisms in miRNA Processing Genes with Type 2 Diabetes Mellitus and Its Vascular Complications in a Southern Chinese Population. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00461"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e14317","DOI":"10.7717\/peerj.14317","article-title":"Association of polymorphic variants in GEMIN genes with the risk of depression in a Polish population","volume":"10","author":"Kowalczyk","year":"2022","journal-title":"PeerJ"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Cho, S.H., Ko, J.J., Kim, J.O., Jeon, Y.J., Yoo, J.K., Oh, J., Oh, D., Kim, J.W., and Kim, N.K. (2015). 3\u2032-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131125"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Yuan, L., Chu, H., Wang, M., Gu, X., Shi, D., Ma, L., Zhong, D., Du, M., Li, P., and Tong, N. (2013). Genetic Variation in DROSHA 3\u2032UTR Regulated by hsa-miR-27b Is Associated with Bladder Cancer Risk. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081524"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_29","first-page":"99","article-title":"The mechanism of RNase III action: How dicer dices","volume":"320","author":"Ji","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/sj.bjc.6605193","article-title":"Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype","volume":"101","author":"Grelier","year":"2009","journal-title":"Br. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s12032-010-9520-5","article-title":"Down-regulation of Dicer in hepatocellular carcinoma","volume":"28","author":"Wu","year":"2010","journal-title":"Med. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1349-7006.2005.00015.x","article-title":"Reduced expression of Dicer associated with poor prognosis in lung cancer patients","volume":"96","author":"Karube","year":"2005","journal-title":"Cancer Sci."},{"key":"ref_33","unstructured":"Adam, M.P., Feldman, J., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J.H., Gripp, K.W., and Amemiya, A. (2024, August 04). DICER1 Tumor Predisposition, GeneReviews\u00ae, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK196157\/."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Robertson, J.C., Jorcyk, C.L., and Oxford, J.T. (2018). DICER1 Syndrome: DICER1 Mutations in Rare Cancers. Cancers, 10.","DOI":"10.3390\/cancers10050143"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.1174334","article-title":"DICER1 Mutations in Familial Pleuropulmonary Blastoma","volume":"325","author":"Hill","year":"2009","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jmedgenet-2015-103428","article-title":"High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome","volume":"53","author":"Wang","year":"2016","journal-title":"J. Med. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ricarte-Filho, J.C., Casado-Medrano, V., Reichenberger, E., Spangler, Z., Scheerer, M., Isaza, A., Baran, J., Patel, T., MacFarland, S.P., and Brodeur, G.M. (2023). DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1083382"},{"key":"ref_38","first-page":"145132","article-title":"Association between genetic variants in DICER1 and cancer risk: An updated meta-analysis","volume":"766","year":"2020","journal-title":"Gene"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.thromres.2019.05.021","article-title":"Influence of genetic polymorphisms in DICER and XPO5 genes on the risk of coronary artery disease and circulating levels of vascular miRNAs","volume":"180","author":"Borghini","year":"2019","journal-title":"Thromb. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/08916934.2016.1230846","article-title":"DICER and DROSHA gene expression and polymorphisms in autoimmune thyroid diseases","volume":"49","author":"Saeki","year":"2016","journal-title":"Autoimmunity"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12031-012-9887-1","article-title":"Evaluation of Six SNPs of MicroRNA Machinery Genes and Risk of Schizophrenia","volume":"49","author":"Zhou","year":"2013","journal-title":"J. Mol. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.preghy.2019.04.005","article-title":"Genetic variants in DICER1, DROSHA, RAN, and XPO5 genes and risk of pregnancy-induced hypertension","volume":"16","author":"Huang","year":"2019","journal-title":"Pregnancy Hypertens."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s13258-017-0605-9","article-title":"Association of rs1057035polymorphism in microRNA biogenesis pathway gene (DICER1) with azoospermia among Iranian population","volume":"40","author":"Moghbelinejad","year":"2018","journal-title":"Genes Genom."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Na Kim, M., Kim, J.O., Lee, S.M., Park, H., Lee, J.H., Rim, K.S., Hwang, S.G., and Kim, N.K. (2016). Variation in the Dicer and RAN Genes Are Associated with Survival in Patients with Hepatocellular Carcinoma. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162279"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Osuch-Wojcikiewicz, E., Bruzgielewicz, A., Niemczyk, K., Sieniawska-Buccella, O., Nowak, A., Walczak, A., and Majsterek, I. (2015). Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population. BioMed. Res. Int., 2015.","DOI":"10.1155\/2015\/298378"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1177\/1535370220934036","article-title":"MicroRNA-892a regulates laryngocarcinoma cell proliferation via Dicer","volume":"245","author":"Dong","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Borg, R., and Cauchi, R.J. (2014). GEMINs: Potential therapeutic targets for spinal muscular atrophy?. Front. Neurosci., 8.","DOI":"10.3389\/fnins.2014.00325"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Aldhalaan, H., AlBakheet, A., AlRuways, S., AlMutairi, N., AlNakiyah, M., AlGhofaili, R., Cardona-Londo\u00f1o, K.J., Alahmadi, K.O., AlQudairy, H., and AlRasheed, M.M. (2021). A Novel GEMIN4 Variant in a Consanguineous Family Leads to Neurodevelopmental Impairment with Severe Microcephaly, Spastic Quadriplegia, Epilepsy, and Cataracts. Genes, 13.","DOI":"10.3390\/genes13010092"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1002\/ajmg.a.62894","article-title":"Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome","volume":"188","author":"Altassan","year":"2022","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00439-016-1747-6","article-title":"Novel phenotypes and loci identified through clinical genomics approaches to pediatric cataract","volume":"136","author":"Patel","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"86435","DOI":"10.18632\/oncotarget.21199","article-title":"Association between SNPs in microRNA machinery genes and gastric cancer susceptibility, invasion, and metastasis in Chinese Han population","volume":"8","author":"Song","year":"2017","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Fang, X., Yin, Z., Li, X., Xia, L., and Zhou, B. (2016). Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13100939"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/carcin\/bgq168","article-title":"Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma","volume":"31","author":"Lin","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e13637","DOI":"10.1097\/MD.0000000000013637","article-title":"Correlation analysis between SNPs in microRNA-machinery genes and tuberculosis susceptibility in the Chinese Uygur population","volume":"97","author":"Cheng","year":"2018","journal-title":"Medicine"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1089\/dna.2011.1600","article-title":"Genetic Variants in the MicroRNA Machinery Gene GEMIN4 Are Associated with Risk of Prostate Cancer: A Case-control Study of the Chinese Han Population","volume":"31","author":"Liu","year":"2012","journal-title":"DNA Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1245\/s10434-014-3709-3","article-title":"Association of miRNA-related Genetic Polymorphisms and Prognosis in Patients with Esophageal Squamous Cell Carcinoma","volume":"21","author":"Yang","year":"2014","journal-title":"Ann. Surg. Oncol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/8\/1054\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:34:36Z","timestamp":1760110476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/8\/1054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,10]]},"references-count":56,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["genes15081054"],"URL":"https:\/\/doi.org\/10.3390\/genes15081054","relation":{},"ISSN":["2073-4425"],"issn-type":[{"type":"electronic","value":"2073-4425"}],"subject":[],"published":{"date-parts":[[2024,8,10]]}}}