{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:35:48Z","timestamp":1787870148450,"version":"build-2784847793"},"reference-count":29,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation MATER program","award":["813707"],"award-info":[{"award-number":["813707"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation MATER program","award":["PRG1076"],"award-info":[{"award-number":["PRG1076"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation MATER program","award":["101120075"],"award-info":[{"award-number":["101120075"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation MATER program","award":["101008193"],"award-info":[{"award-number":["101008193"]}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["813707"],"award-info":[{"award-number":["813707"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["PRG1076"],"award-info":[{"award-number":["PRG1076"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["101120075"],"award-info":[{"award-number":["101120075"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"publisher","award":["101008193"],"award-info":[{"award-number":["101008193"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Commission","award":["813707"],"award-info":[{"award-number":["813707"]}]},{"name":"European Commission","award":["PRG1076"],"award-info":[{"award-number":["PRG1076"]}]},{"name":"European Commission","award":["101120075"],"award-info":[{"award-number":["101120075"]}]},{"name":"European Commission","award":["101008193"],"award-info":[{"award-number":["101008193"]}]},{"name":"MSCA-RISE-2020 project TRENDO","award":["813707"],"award-info":[{"award-number":["813707"]}]},{"name":"MSCA-RISE-2020 project TRENDO","award":["PRG1076"],"award-info":[{"award-number":["PRG1076"]}]},{"name":"MSCA-RISE-2020 project TRENDO","award":["101120075"],"award-info":[{"award-number":["101120075"]}]},{"name":"MSCA-RISE-2020 project TRENDO","award":["101008193"],"award-info":[{"award-number":["101008193"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Endometriosis is a chronic hormone-dependent disease characterized by the spread of endometrial cells outside the uterus, which form endometriotic lesions and disrupt the functions of the affected organs. The etiopathogenesis of endometriosis is still unclear, and thus it is important to examine the genes that may contribute to the establishment of endometriotic lesions. The aim of this study was to investigate the expression of new potential candidate gene latexin (LXN), an inhibitor of carboxypeptidases, in endometrium and endometriotic lesions to elucidate its possible role in endometriosis development. LXN expression in tissues was assessed using quantitative reverse transcription PCR (qRT\u2013PCR) analysis and immunohistochemical staining (IHC). The functions of LXN were examined using Transwell and MTT assays. qRT\u2013PCR analysis revealed that LXN expression in endometrium was menstrual cycle-dependent, being lowest in the early-secretory phase and highest in the late-secretory phase and was significantly upregulated in endometriotic lesions. IHC confirmed LXN expression in endometrial stromal cells, and in vitro assays demonstrated that knockdown of LXN effectively reduced the migratory capacity of endometrial stromal cells while promoting cell viability. In conclusion, our results showed that LXN can be involved in the pathogenesis of endometriosis by regulating the proliferation and migration activity of endometriotic stromal cells.<\/jats:p>","DOI":"10.3390\/genes15081086","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:43:28Z","timestamp":1724039008000},"page":"1086","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Carboxypeptidase Inhibitor LXN Expression in Endometrial Tissue Is Menstrual Cycle Phase-Dependent and Is Upregulated in Endometriotic Lesions"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-732X","authenticated-orcid":false,"given":"Meruert","family":"Sarsenova","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 50406 Tartu, Estonia"},{"name":"Department of Women\u2019s and Children\u2019s Health, Division of Obstetrics and Gynecology, Karolinska Institutet, and Karolinska University Hospital, 17177 Stockholm, Sweden"},{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artjom","family":"Stepanjuk","sequence":"additional","affiliation":[{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merli","family":"Saare","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 50406 Tartu, Estonia"},{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergo","family":"Kasvandik","sequence":"additional","affiliation":[{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Soplepmann","sequence":"additional","affiliation":[{"name":"Tartu University Hospital Women\u2019s Clinic, 50406 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Mikeltadze","sequence":"additional","affiliation":[{"name":"Department of Surgical and Gynecological Oncology, Tartu University Hospital, 50406 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-2496","authenticated-orcid":false,"given":"Martin","family":"G\u00f6tte","sequence":"additional","affiliation":[{"name":"Department of Gynecology, and Obstetrics, University Hospital of M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Salumets","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 50406 Tartu, Estonia"},{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"},{"name":"Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, and Karolinska University Hospital, 17177 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maire","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Institute of Clinical Medicine, University of Tartu, 50406 Tartu, Estonia"},{"name":"Competence Centre on Health Technologies, 50411 Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.fertnstert.2017.08.036","article-title":"Pathogenesis of deep endometriosis","volume":"108","author":"Gordts","year":"2017","journal-title":"Fertil. 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