{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:21:38Z","timestamp":1760145698371,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"governmental agencies","award":["CAPES-14\/2021","FAPERJ-E-26\/204.117\/2021"],"award-info":[{"award-number":["CAPES-14\/2021","FAPERJ-E-26\/204.117\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Maximal oxygen uptake (VO2max) is a determining indicator for cardiorespiratory capacity in endurance athletes, and epigenetics is crucial in its levels and variability. This initial study examined a broad plasma miRNA profile of twenty-three trained elite endurance athletes with similar training volumes but different VO2max in response to an acute maximal graded endurance test. Six were clustered as higher\/lower levels based on their VO2max (75.4 \u00b1 0.9 and 60.1 \u00b1 5.0 mL.kg\u22121.min\u22121). Plasma was obtained from athletes before and after the test and 15 ng of total RNA was extracted and detected using an SYBR-based 1113 miRNA RT-qPCR panel. A total of 51 miRNAs were differentially expressed among group comparisons. Relative amounts of miRNA showed a clustering behavior among groups regarding distinct performance\/time points. Significantly expressed miRNAs were used to perform functional bioinformatic analysis (DIANA tools). Fatty acid metabolism pathways were strongly targeted for the significantly different miRNAs in all performance groups and time points (p &lt; 0.001). Although this pathway does not solely determine endurance performance, their significant contribution is certainly achieved through the involvement of miRNAs. A highly genetically dependent gold standard variable for performance evaluation in a homogeneous group of elite athletes allowed genetic\/epigenetic aspects related to fatty acid pathways to emerge.<\/jats:p>","DOI":"10.3390\/genes15081088","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:43:28Z","timestamp":1724039008000},"page":"1088","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Circulating miRNA Signaling for Fatty Acid Metabolism in Response to a Maximum Endurance Test in Elite Long-Distance Runners"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6037-6817","authenticated-orcid":false,"given":"Dailson","family":"Paulucio","sequence":"first","affiliation":[{"name":"Biometrics Laboratory (LADEBIO), Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Ramirez-Sanchez","sequence":"additional","affiliation":[{"name":"Biometrics Laboratory (LADEBIO), Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-3600","authenticated-orcid":false,"given":"Rodolfo","family":"Velasque","sequence":"additional","affiliation":[{"name":"Biometrics Laboratory (LADEBIO), Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2336-1937","authenticated-orcid":false,"given":"Raphael","family":"Xavier","sequence":"additional","affiliation":[{"name":"Biometrics Laboratory (LADEBIO), Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Monnerat","sequence":"additional","affiliation":[{"name":"Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0948-9112","authenticated-orcid":false,"given":"Adrieli","family":"Dill","sequence":"additional","affiliation":[{"name":"Brazilian Army Institute of Biology, Research, Teaching and Research Division, Rio de Janeiro 20911-270, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4796-6393","authenticated-orcid":false,"given":"Juliano","family":"Silveira","sequence":"additional","affiliation":[{"name":"Faculty of Animal Sciences and Food Engineering, Universidade de S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8095-3738","authenticated-orcid":false,"given":"Gabriella M.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Faculty of Animal Sciences and Food Engineering, Universidade de S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0372-4920","authenticated-orcid":false,"given":"Flavio","family":"Meirelles","sequence":"additional","affiliation":[{"name":"Faculty of Animal Sciences and Food Engineering, Universidade de S\u00e3o Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Dornelas-Ribeiro","sequence":"additional","affiliation":[{"name":"Brazilian Army Institute of Biology, Research, Teaching and Research Division, Rio de Janeiro 20911-270, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Kirchner","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich, Liesel-Beckmann-Stra\u00dfe 1, 85354 Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3192-1019","authenticated-orcid":false,"given":"Michael W.","family":"Pfaffl","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Immunology, School of Life Sciences, Technical University of Munich, Liesel-Beckmann-Stra\u00dfe 1, 85354 Freising, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Pompeu","sequence":"additional","affiliation":[{"name":"Biometrics Laboratory (LADEBIO), Federal University of Rio de Janeiro, Rio de Janeiro 21941-599, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-0049","authenticated-orcid":false,"given":"Caleb G. 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