{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T10:57:39Z","timestamp":1780052259943,"version":"3.53.1"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FONDECYT-Iniciaci\u00f3n","award":["11190602"],"award-info":[{"award-number":["11190602"]}]},{"name":"FONDECYT-Iniciaci\u00f3n","award":["1220708"],"award-info":[{"award-number":["1220708"]}]},{"name":"FONDECYT-Iniciaci\u00f3n","award":["EQM200056"],"award-info":[{"award-number":["EQM200056"]}]},{"name":"FONDECYT-Regular","award":["11190602"],"award-info":[{"award-number":["11190602"]}]},{"name":"FONDECYT-Regular","award":["1220708"],"award-info":[{"award-number":["1220708"]}]},{"name":"FONDECYT-Regular","award":["EQM200056"],"award-info":[{"award-number":["EQM200056"]}]},{"name":"FONDEQUIP","award":["11190602"],"award-info":[{"award-number":["11190602"]}]},{"name":"FONDEQUIP","award":["1220708"],"award-info":[{"award-number":["1220708"]}]},{"name":"FONDEQUIP","award":["EQM200056"],"award-info":[{"award-number":["EQM200056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Acinetobacter bereziniae has emerged as a significant human pathogen, acquiring multiple antibiotic resistance genes, including carbapenemases. This study focuses on characterizing the plasmids harboring the blaNDM-1 and tet(Y) genes in two carbapenem-resistant A. bereziniae isolates (UCO-553 and UCO-554) obtained in Chile during the COVID-19 pandemic. Methods: Antibiotic susceptibility testing was conducted on UCO-553 and UCO-554. Both isolates underwent whole-genome sequencing to ascertain their sequence type (ST), core genome multilocus sequence-typing (cgMLST) profile, antibiotic resistance genes, plasmids, and mobile genetic elements. Conjugation experiments were performed for both isolates. Results: Both isolates exhibited broad resistance, including resistance to carbapenems, third-generation cephalosporins, fluoroquinolones, tetracycline, cotrimoxazole, and aminoglycosides. Both isolates belong to sequence type STPAS1761, with a difference of 17 out of 2984 alleles. Each isolate carried a 47,274 bp plasmid with blaNDM-1 and aph(3\u2032)-VI genes and two highly similar plasmids: a 35,184 bp plasmid with tet(Y), sul2, aph(6)-Id, and aph(3\u2033)-Ib genes, and a 6078 bp plasmid containing the ant(2\u2033)-Ia gene. Quinolone-resistance mutations were identified in the gyrA and parC genes of both isolates. Importantly, blaNDM-1 was located within a Tn125 transposon, and tet(Y) was embedded in a Tn5393 transposon. Conjugation experiments successfully transferred blaNDM-1 and tet(Y) into the A. baumannii ATCC 19606 strain, indicating the potential for horizontal gene transfer. Conclusions: This study highlights the critical role of plasmids in disseminating resistance genes in A. bereziniae and underscores the need for the continued genomic surveillance of this emerging pathogen. The findings emphasize the importance of monitoring A. bereziniae for its potential to cause difficult-to-treat infections and its capacity to spread resistance determinants against clinically significant antibiotics.<\/jats:p>","DOI":"10.3390\/genes15091213","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:51:43Z","timestamp":1726620703000},"page":"1213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Co-Occurrence of Two Plasmids Encoding Transferable blaNDM-1 and tet(Y) Genes in Carbapenem-Resistant Acinetobacter bereziniae"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-7625","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Opazo-Capurro","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-8184","authenticated-orcid":false,"given":"Kyriaki","family":"Xanthopoulou","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Arazo del Pino","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Gonz\u00e1lez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Ciencias Biol\u00f3gicas y Qu\u00edmicas, Facultad de Medicina y Ciencia, Universidad San Sebasti\u00e1n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Matus-K\u00f6hler","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Amsteins-Romero","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8406-6258","authenticated-orcid":false,"given":"Christian","family":"Jerez-Olate","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Facultad de Odontolog\u00eda y Ciencias de la Rehabilitaci\u00f3n, Universidad San Sebasti\u00e1n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Hormaz\u00e1bal","sequence":"additional","affiliation":[{"name":"Instituto de Salud P\u00fablica (ISP), Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-7194","authenticated-orcid":false,"given":"Rodrigo","family":"Vera","sequence":"additional","affiliation":[{"name":"Hospital de Urgencia Asistencia P\u00fablica, Santiago 8320000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-931X","authenticated-orcid":false,"given":"Felipe","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Centro de Biotecnolog\u00eda, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Fuller","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-9454","authenticated-orcid":false,"given":"Paul G.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne, D-50937 Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, D-50937 Cologne, Germany"},{"name":"Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, D-50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2351-1236","authenticated-orcid":false,"given":"Gerardo","family":"Gonz\u00e1lez-Rocha","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Agentes Antibacterianos (LIAA), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"},{"name":"Grupo de Estudio en Resistencia Antimicrobiana (GRAM), Universidad de Concepci\u00f3n, Concepci\u00f3n 4070386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1089\/mdr.2019.0210","article-title":"Genomic and Clinical Characterization of IMP-1-Producing Multidrug-Resistant Acinetobacter Bereziniae Isolates from Bloodstream Infections in a Brazilian Tertiary Hospital","volume":"26","author":"Tavares","year":"2020","journal-title":"Microb. 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