{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:31:08Z","timestamp":1784748668039,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University\u2014Sofia","award":["D-135\/04.06.2021"],"award-info":[{"award-number":["D-135\/04.06.2021"]}]},{"name":"Medical University\u2014Sofia","award":["7859\/18.11.2020"],"award-info":[{"award-number":["7859\/18.11.2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Periodontitis is a complex disease, and bacterial factors play a crucial role in its initiation. The contributions of genetic and epigenetic factors to the pathogenesis of periodontal disease are increasingly recognized. Single-nucleotide polymorphisms (SNPs) in various molecules, including cytokines, are of particular interest due to their established involvement in numerous diseases. This study investigates the influence of SNPs in the IL-10 gene at positions \u2212592 (rs1800872) C&gt;A and \u22121082 (rs1800896) T&gt;C (also referred to as 1082A&gt;G) on the severity of periodontitis in a cohort of Bulgarian patients. Methods: In the recent study, both clinical and paraclinical methodologies were employed to comprehensively assess the periodontal status of the participants. The genotypic characterization of IL-10 polymorphisms was performed by PCR RFLP analysis. Statistical analyses, including principal component analysis (PCA), were executed utilizing IBM SPSS Statistics Version 21. Results: We have established a statistically significant association between the presence of at least one A-allele in the patients\u2019 genotype and the incidence of severe periodontitis (p = 0.047). Conclusions: IL-10 single-nucleotide polymorphisms (SNPs) could be effectively considered as biomarkers for the severity of periodontitis.<\/jats:p>","DOI":"10.3390\/genes15091221","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T03:34:20Z","timestamp":1726716860000},"page":"1221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["IL-10 A-Allele as a Biomarker for Periodontitis Severity in Bulgarian Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-083X","authenticated-orcid":false,"given":"Zdravka","family":"Pashova-Tasseva","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velitchka","family":"Dosseva-Panova","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoaneta","family":"Mlachkova","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Medical University of Sofia, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Savov","sequence":"additional","affiliation":[{"name":"National Genetic Laboratory, University Hospital of Obstetrics, Medical University, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-3557","authenticated-orcid":false,"given":"Ekaterina","family":"Tosheva","sequence":"additional","affiliation":[{"name":"Department of Statistics and Econometrics, Faculty of Applied Informatics and Statistics, University of National and World Economy, 1000 Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.7546\/CRABS.2023.01.15","article-title":"Periodontal Status of Active Age Population in the Republic of Bulgaria","volume":"76","author":"Nenov","year":"2023","journal-title":"Proc. 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