{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:31:24Z","timestamp":1760146284904,"version":"build-2065373602"},"reference-count":72,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vice Rector of Research and Development (VRID) of the Universidad de Concepci\u00f3n","award":["1110687","218.087.043-1.0","21201061"],"award-info":[{"award-number":["1110687","218.087.043-1.0","21201061"]}]},{"name":"PhD scholarship in Chile ANID","award":["1110687","218.087.043-1.0","21201061"],"award-info":[{"award-number":["1110687","218.087.043-1.0","21201061"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: Post-traumatic stress disorder (PTSD) is a complex condition influenced by both genetic and environmental factors. This longitudinal study aimed to explore the connection between two specific genetic polymorphisms, Val66Met and 5-HTTLPR, and the lifetime prevalence of PTSD in patients from primary care settings. We also examined the role of sociodemographic and psychosocial factors to provide a more comprehensive view of PTSD risk. Methods: We recruited a cohort of primary care patients and diagnosed PTSD using a standardized diagnostic interview. Genetic analyses focused on Val66Met and 5-HTTLPR polymorphisms. We applied logistic regression to assess the association between these genetic markers and PTSD, considering factors such as gender, family history of depression, and experiences of childhood maltreatment. Results: Our findings show that women, individuals with a family history of depression, and those exposed to childhood maltreatment have a higher risk of developing PTSD. While the Val66Met polymorphism was not significantly associated with PTSD, the 5-HTTLPR polymorphism showed a marginal relationship. No significant interaction was found between the two polymorphisms in relation to PTSD. Conclusions: This study underscores the multifactorial nature of PTSD, influenced by both genetic and environmental factors. The findings point to the importance of further research on genetic predispositions and highlight the value of early interventions for high-risk populations in primary care settings.<\/jats:p>","DOI":"10.3390\/genes15111355","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:11:25Z","timestamp":1729577485000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of Val66Met Brain-Derived Neurotrophic Factor and 5-HTTLPR Serotonin Transporter Gene Polymorphisms with Lifetime Prevalence of Post-Traumatic Stress Disorder in Primary Care Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-4650","authenticated-orcid":false,"given":"Alejandra","family":"Guzman-Castillo","sequence":"first","affiliation":[{"name":"Departamento de Ciencias B\u00e1sicas y Morfolog\u00eda, Facultad de Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Av. Alonso de Ribera 2850, Concepci\u00f3n 4090541, Chile"},{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjam\u00edn","family":"Vicente","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina, Universidad de Concepci\u00f3n, Av. Juan Bosco s\/n 3er Piso, Box 160-C, Concepci\u00f3n 4070529, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina, Universidad de Concepci\u00f3n, Av. Juan Bosco s\/n 3er Piso, Box 160-C, Concepci\u00f3n 4070529, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7012-6309","authenticated-orcid":false,"given":"Esteban","family":"Moraga-Escobar","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Rojas-Ponce","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Farmacolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Box 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3440-026X","authenticated-orcid":false,"given":"Paola","family":"Lagos","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Box 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Macaya","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina, Universidad de Concepci\u00f3n, Av. Juan Bosco s\/n 3er Piso, Box 160-C, Concepci\u00f3n 4070529, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-2384","authenticated-orcid":false,"given":"Juan-Luis","family":"Castillo-Navarrete","sequence":"additional","affiliation":[{"name":"Programa de Neurociencia, Psiquiatr\u00eda y Salud Mental, NEPSAM (<a href=\"http:\/\/nepsam.udec.cl\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/nepsam.udec.cl<\/a>), Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Casilla 160-C, Concepci\u00f3n 4070386, Chile"},{"name":"Departamento de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad de Concepci\u00f3n, Barrio Universitario s\/n, Box 160-C, Concepci\u00f3n 4070386, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mojtabavi, H., Saghazadeh, A., van den Heuvel, L., Bucker, J., and Rezaei, N. 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