{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:21:50Z","timestamp":1788474110076,"version":"build-2803163510"},"reference-count":87,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MEAE AMBASS FRANCE AU PEROU FSPI","award":["S-AC23007"],"award-info":[{"award-number":["S-AC23007"]}]},{"name":"MEAE AMBASS FRANCE AU PEROU FSPI","award":["S-AC23007"],"award-info":[{"award-number":["S-AC23007"]}]},{"name":"Fili\u00e8re Sant\u00e9 Maladie Rare du Foie de l\u2019Adulte et de l\u2019Enfant","award":["S-AC23007"],"award-info":[{"award-number":["S-AC23007"]}]},{"name":"Fili\u00e8re Sant\u00e9 Maladie Rare du Foie de l\u2019Adulte et de l\u2019Enfant","award":["S-AC23007"],"award-info":[{"award-number":["S-AC23007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Hepatoblastoma, the most common pediatric liver malignancy, is characterized by significant molecular heterogeneity and poor prognosis in advanced stages. Recent studies highlight the importance of metabolic reprogramming and epigenetic dysregulation in hepatoblastoma pathogenesis. This review aims to explore the metabolic alterations and epigenetic mechanisms involved in hepatoblastoma and how these processes contribute to tumor progression and survival. Methods: Relevant literature on metabolic reprogramming, including enhanced glycolysis, mitochondrial dysfunction, and shifts in lipid and amino acid metabolism, as well as epigenetic mechanisms like DNA methylation, histone modifications, and non-coding RNAs, was reviewed. The interplay between these pathways and their potential as therapeutic targets were examined. Results: Hepatoblastoma exhibits metabolic shifts that support tumor growth and survival, alongside epigenetic changes that regulate gene expression and promote tumor progression. These pathways are interconnected, with metabolic changes influencing the epigenetic landscape and vice versa. Conclusions: The dynamic interplay between metabolism and epigenetics in hepatoblastoma offers promising avenues for therapeutic intervention. Future research should focus on integrating metabolic and epigenetic therapies to improve patient outcomes, addressing current gaps in knowledge to develop more effective treatments.<\/jats:p>","DOI":"10.3390\/genes15111358","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:53:43Z","timestamp":1729583623000},"page":"1358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metabolic and Epigenetic Mechanisms in Hepatoblastoma: Insights into Tumor Biology and Therapeutic Targets"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-8230","authenticated-orcid":false,"given":"Yuanji","family":"Fu","sequence":"first","affiliation":[{"name":"CNRS, INSERM, Institut Necker Enfants Malades, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-4852","authenticated-orcid":false,"given":"Raquel","family":"Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-5857","authenticated-orcid":false,"given":"Claudia","family":"Monge","sequence":"additional","affiliation":[{"name":"INSERM U993, Unit\u00e9 Organisation Nucl\u00e9aire et Oncogen\u00e8se, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-2524","authenticated-orcid":false,"given":"Christophe","family":"Desterke","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine du Kremlin Bic\u00eatre, Universit\u00e9 Paris-Sud, Universit\u00e9 Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Marchio","sequence":"additional","affiliation":[{"name":"INSERM U993, Unit\u00e9 Organisation Nucl\u00e9aire et Oncogen\u00e8se, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-1592","authenticated-orcid":false,"given":"Pascal","family":"Pineau","sequence":"additional","affiliation":[{"name":"INSERM U993, Unit\u00e9 Organisation Nucl\u00e9aire et Oncogen\u00e8se, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Chang-Marchand","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, Institut Necker Enfants Malades, Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5726-8814","authenticated-orcid":false,"given":"Jorge","family":"Mata-Garrido","sequence":"additional","affiliation":[{"name":"INSERM U993, Unit\u00e9 Organisation Nucl\u00e9aire et Oncogen\u00e8se, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/pbc.24215","article-title":"The epidemiology of hepatoblastoma","volume":"59","author":"Spector","year":"2012","journal-title":"Pediatr. 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