{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:41:21Z","timestamp":1790185281178,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Econom\u00eda, Industria y Competitividad","award":["PID2022-139016OA\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-139016OA\/AEI\/10.13039\/501100011033"]}]},{"name":"Ministerio de Econom\u00eda, Industria y Competitividad","award":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"]}]},{"name":"Ministerio de Econom\u00eda, Industria y Competitividad","award":["2021 SGR 00357"],"award-info":[{"award-number":["2021 SGR 00357"]}]},{"name":"Ministerio de Econom\u00eda, Industria y Competitividad","award":["Llavor 00086"],"award-info":[{"award-number":["Llavor 00086"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n, AEI","award":["PID2022-139016OA\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-139016OA\/AEI\/10.13039\/501100011033"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n, AEI","award":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n, AEI","award":["2021 SGR 00357"],"award-info":[{"award-number":["2021 SGR 00357"]}]},{"name":"Agencia Estatal de Investigaci\u00f3n, AEI","award":["Llavor 00086"],"award-info":[{"award-number":["Llavor 00086"]}]},{"name":"Fondo Europeo de Desarrollo Regional (MINECO-FEDER)","award":["PID2022-139016OA\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-139016OA\/AEI\/10.13039\/501100011033"]}]},{"name":"Fondo Europeo de Desarrollo Regional (MINECO-FEDER)","award":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"]}]},{"name":"Fondo Europeo de Desarrollo Regional (MINECO-FEDER)","award":["2021 SGR 00357"],"award-info":[{"award-number":["2021 SGR 00357"]}]},{"name":"Fondo Europeo de Desarrollo Regional (MINECO-FEDER)","award":["Llavor 00086"],"award-info":[{"award-number":["Llavor 00086"]}]},{"name":"Generalitat de Catalunya","award":["PID2022-139016OA\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-139016OA\/AEI\/10.13039\/501100011033"]}]},{"name":"Generalitat de Catalunya","award":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"]}]},{"name":"Generalitat de Catalunya","award":["2021 SGR 00357"],"award-info":[{"award-number":["2021 SGR 00357"]}]},{"name":"Generalitat de Catalunya","award":["Llavor 00086"],"award-info":[{"award-number":["Llavor 00086"]}]},{"name":"Secretaria d\u2019Universitats i Recerca del Departament d\u2019Empresai Coneixement de la Generalitat de Catalunya 2021","award":["PID2022-139016OA\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-139016OA\/AEI\/10.13039\/501100011033"]}]},{"name":"Secretaria d\u2019Universitats i Recerca del Departament d\u2019Empresai Coneixement de la Generalitat de Catalunya 2021","award":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["PID2022-13809OB-100\/AEI\/10.13039\/501100011033"]}]},{"name":"Secretaria d\u2019Universitats i Recerca del Departament d\u2019Empresai Coneixement de la Generalitat de Catalunya 2021","award":["2021 SGR 00357"],"award-info":[{"award-number":["2021 SGR 00357"]}]},{"name":"Secretaria d\u2019Universitats i Recerca del Departament d\u2019Empresai Coneixement de la Generalitat de Catalunya 2021","award":["Llavor 00086"],"award-info":[{"award-number":["Llavor 00086"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: The senescence-accelerated mouse 8 (SAMP8) represents a model for Alzheimer\u2019s disease (AD) research because it exhibits age-related learning and memory impairments consistent with early onset and rapid progression of senescence. To identify transcriptional changes during AD progression, in this study, we analyzed and compared the gene expression profiles involved in molecular pathways of neurodegeneration and cognitive impairment in senescence-accelerated resistant 1 (SAMR1) and SAMP8 mice. Methods: In total, 48 female SAMR1 and SAMP8 mice were randomly divided into six groups (SAMR1 and SAMP8 at 3, 7, and 9 months of age). Microarray analysis of 22,000 genes was performed, followed by functional analysis using Gene Ontology (NCBI) and examination of altered molecular pathways using the KEGG (Kyoto Encyclopedia of Genes and Genomes). Results: SAMP8 mice had 2516 dysregulated transcripts at 3 months, 2549 transcripts at 7 months, and 2453 genes at 9 months compared to SAMR1 mice of the same age. These accounted for 11.3% of the total number. This showed that with age, the gene expression of downregulated transcripts increases, and that of over-expressed transcripts decreases. Most of these genes were involved in neurodegenerative metabolic pathways associated with Alzheimer\u2019s disease: apoptosis, inflammatory response, oxidative stress, and mitochondria. The qPCR results indicated that Ndufs4, TST\/Rhodanese, Wnt3, and Sema6a expression was differentially expressed during aging. Conclusions: These results further revealed significant differences in gene expression profiles at different ages between SAMR1 and SAMP8 and showed alteration in genes involved in age-related cognitive decline and mitochondrial processes, demonstrating the relevance of the SAMP8 model as a model for sporadic AD.<\/jats:p>","DOI":"10.3390\/genes15111411","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T06:55:37Z","timestamp":1730357737000},"page":"1411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in Gene Expression Profile with Age in SAMP8: Identifying Transcripts Involved in Cognitive Decline and Sporadic Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5424-9130","authenticated-orcid":false,"given":"Christian","family":"Gri\u00f1\u00e1n-Ferr\u00e9","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris Valeria","family":"Servin-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunolog\u00eda Molecular, Instituto de Investigaci\u00f3n de Ciencias Biom\u00e9dicas (IICB) CUCS, Universidad de Guadalajara, Jalisco 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Palomera-\u00c1valos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-4387","authenticated-orcid":false,"given":"Carmen","family":"Mart\u00ednez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7102-7700","authenticated-orcid":false,"given":"J\u00falia","family":"Companys-Alemany","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Mu\u00f1oz-Villanova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-2514","authenticated-orcid":false,"given":"Daniel","family":"Ortu\u00f1o-Sahag\u00fan","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroinmunolog\u00eda Molecular, Instituto de Investigaci\u00f3n de Ciencias Biom\u00e9dicas (IICB) CUCS, Universidad de Guadalajara, Jalisco 44340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-4254","authenticated-orcid":false,"given":"Merc\u00e8","family":"Pall\u00e0s","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Bellver-Sanchis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic Chemistry, Institut de Neuroci\u00e8ncies-Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. 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