{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:10:03Z","timestamp":1770228603980,"version":"3.49.0"},"reference-count":162,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research Development Program of China","award":["2022YFD1700504"],"award-info":[{"award-number":["2022YFD1700504"]}]},{"name":"National Key Research Development Program of China","award":["32472621"],"award-info":[{"award-number":["32472621"]}]},{"name":"National Key Research Development Program of China","award":["CARS-23-C07"],"award-info":[{"award-number":["CARS-23-C07"]}]},{"name":"National Key Research Development Program of China","award":["Qiankehezhongyindi (2024) 007"],"award-info":[{"award-number":["Qiankehezhongyindi (2024) 007"]}]},{"name":"National Natural Science Foundation of China","award":["2022YFD1700504"],"award-info":[{"award-number":["2022YFD1700504"]}]},{"name":"National Natural Science Foundation of China","award":["32472621"],"award-info":[{"award-number":["32472621"]}]},{"name":"National Natural Science Foundation of China","award":["CARS-23-C07"],"award-info":[{"award-number":["CARS-23-C07"]}]},{"name":"National Natural Science Foundation of China","award":["Qiankehezhongyindi (2024) 007"],"award-info":[{"award-number":["Qiankehezhongyindi (2024) 007"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["2022YFD1700504"],"award-info":[{"award-number":["2022YFD1700504"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["32472621"],"award-info":[{"award-number":["32472621"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["CARS-23-C07"],"award-info":[{"award-number":["CARS-23-C07"]}]},{"name":"China Agriculture Research System of MOF and MARA","award":["Qiankehezhongyindi (2024) 007"],"award-info":[{"award-number":["Qiankehezhongyindi (2024) 007"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["2022YFD1700504"],"award-info":[{"award-number":["2022YFD1700504"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["32472621"],"award-info":[{"award-number":["32472621"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["CARS-23-C07"],"award-info":[{"award-number":["CARS-23-C07"]}]},{"name":"Central Government Guides Local Science and Technology Development Fund Projects","award":["Qiankehezhongyindi (2024) 007"],"award-info":[{"award-number":["Qiankehezhongyindi (2024) 007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Research into the biology of plant viruses, their mechanisms of pathogenicity, and the induction of host resistance has laid a solid foundation for the discovery of antiviral agents and their targets and the development of effective control technologies. Additionally, recent advancements in fields such as chemical biology, cheminformatics, bioinformatics, and synthetic biology have provided valuable methods and tools for the design of antiviral drugs, the synthesis of drug molecules, assessment of their activity, and investigation of their modes of action. Compared with drug development for human viral diseases, the control of plant viral diseases presents greater challenges, including the cost-benefit of agents, simplification of control technologies, and the effectiveness of treatments. Therefore, in the current context of complex outbreaks and severe damage caused by plant viral diseases, it is crucial to delve deeper into the research and development of antiviral agents. This review provides a detailed overview of the biological characteristics of current targets for antiviral agents, the mode of interaction between plant virus targets and antivirals, and insights for future drug development. We believe this review will not only facilitate the in-depth analysis of the development of antivirals for crops but also offer valuable perspectives for the development of antiviral agents for use in human and veterinary medicine.<\/jats:p>","DOI":"10.3390\/genes15121654","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:58:27Z","timestamp":1734933507000},"page":"1654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chemical and Biological Investigations of Antiviral Agents Against Plant Viruses Conducted in China in the 21st Century"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-9722","authenticated-orcid":false,"given":"Yuanyou","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongtong","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Agriculture, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-8614","authenticated-orcid":false,"given":"Libo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Forestry, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-8457","authenticated-orcid":false,"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/acs.jafc.2c07315","article-title":"Recent achievements in antiviral agent development for plant protection","volume":"71","author":"Jin","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/jipb.13580","article-title":"Plant virology in the 21st century in China: Recent advances and future directions","volume":"66","author":"Wu","year":"2024","journal-title":"J. Integr. Plant Biol."},{"key":"ref_3","first-page":"905","article-title":"The development and application of pesticides against the disease caused by Southern rice black-streaked dwarf virus","volume":"44","author":"Chen","year":"2017","journal-title":"J. Plant Prot. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1002\/ps.7433","article-title":"Novel cinnamic acid derivatives as a versatile tool for developing agrochemicals for controlling plant virus and bacterial diseases by enhancing plant defense responses","volume":"79","author":"Yang","year":"2023","journal-title":"Pest Manag. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Naz, M., Zhang, D., Liao, K., Chen, X., Ahmed, N., Wang, D., Zhou, J., and Chen, Z. (2024). The past, present, and future of plant activators targeting the salicylic acid signaling pathway. Genes, 15.","DOI":"10.20944\/preprints202407.1424.v1"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chen, Z., Zeng, M., Song, B., Hou, C., Hu, D., Li, X., Wang, Z., Fan, H., Bi, L., and Liu, J. (2012). Dufulin activates HrBP1 to produce antiviral responses in tobacco. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0037944"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, Z., Yang, B., Ding, Y., Meng, J., Hu, J., Zhou, X., Liu, L., Wu, Z., and Yang, S. (2023). Insights into a class of natural eugenol and its optimized derivatives as potential tobacco mosaic virus helicase inhibitors by structure-based virtual screening. Int. J. Biol. Macromol., 248.","DOI":"10.1016\/j.ijbiomac.2023.125892"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/ps.4854","article-title":"Antiphytoviral toxins of Actinidia chinensis root bark (ACRB) extract: Laboratory and semi-field trials","volume":"74","author":"Zhang","year":"2018","journal-title":"Pest Manag. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/ps.6049","article-title":"Anti-TMV activity and mode of action of three alkaloids isolated from Chelidonium majus","volume":"77","author":"Guo","year":"2021","journal-title":"Pest Manag. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.antiviral.2011.08.014","article-title":"Antiviral activity of tenofovir against cauliflower mosaic virus and its metabolism in Brassica pekinensis plants","volume":"92","author":"Spak","year":"2011","journal-title":"Antivir. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.1021\/acs.jafc.0c03994","article-title":"Streptindole and its derivatives as novel antiviral and anti-phytopathogenic fungus agents","volume":"68","author":"Kang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1021\/acs.jafc.9b04093","article-title":"Optimization, structure-activity relationship, and mode of action of nortopsentin analogues containing thiazole and oxazole moieties","volume":"67","author":"Guo","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","first-page":"451","article-title":"\u00dcber die Mosaikkrankheit des Tabaks","volume":"32","author":"Mayer","year":"1886","journal-title":"Landwirtsch. Vers. Stn."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1073\/pnas.90.5.2055","article-title":"Genomic position affects the expression of tobacco mosaic virus movement and coat protein genes","volume":"90","author":"Culver","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Lumata, J.L., Ball, D., Shahrivarkevishahi, A., Luzuriaga, M.A., Herbert, F.C., Brohlin, O., Lee, H., Hagge, L.M., D\u2019Arcy, S., and Gassensmith, J.J. (2021). Identification and physical characterization of a spontaneous mutation of the tobacco mosaic virus in the laboratory environment. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-94561-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.1073\/pnas.1018104108","article-title":"Hydrogen-bonding networks and RNA bases revealed by cryo electron microscopy suggest a triggering mechanism for calcium switches","volume":"108","author":"Ge","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.virol.2007.03.052","article-title":"Coat protein-mediated resistance to TMV infection of Nicotiana tabacum involves multiple modes of interference by coat protein","volume":"366","author":"Bendahmane","year":"2007","journal-title":"Virology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1098\/rstb.1999.0413","article-title":"Replication of tobacco mosaic virus RNA","volume":"354","author":"Buck","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zerbini, F.M., and Kitajima, E.W. (2022). From Contagium vivum fluidum to Riboviria: A tobacco mosaic virus-centric history of virus taxonomy. Biomolecules, 12.","DOI":"10.3390\/biom12101363"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0065-227X(90)90011-H","article-title":"Switching in the self-assembly of tobacco mosaic virus","volume":"26","author":"Caspar","year":"1990","journal-title":"Adv. Biophys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/jvi.71.4.2583-2590.1997","article-title":"Virus-encoded RNA helicases","volume":"71","author":"Haenni","year":"1997","journal-title":"J. Virol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1099\/0022-1317-73-8-2129","article-title":"Conservation of the putative methyltransferase domain: A hallmark of the \u2018Sindbis-like\u2019 supergroup of positive-strand RNA viruses","volume":"73","author":"Rozanov","year":"1992","journal-title":"J. Gen. Virol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF01310564","article-title":"Molecular anatomy of viral RNA-directed RNA polymerases","volume":"134","author":"Ishihama","year":"1994","journal-title":"Arch. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/viro.1998.9463","article-title":"Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure","volume":"252","author":"Kao","year":"1998","journal-title":"Virology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/viro.1998.9457","article-title":"Infection of tobacco or Arabidopsis plants by CMV counteracts systemic post-transcriptional silencing of nonviral (trans) genes","volume":"252","author":"Palauqui","year":"1998","journal-title":"Virology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-313X.2011.04774.x","article-title":"Cucumber mosaic virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activities","volume":"69","author":"Hamera","year":"2012","journal-title":"Plant J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1101\/gad.1495506","article-title":"Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense","volume":"20","author":"Zhang","year":"2006","journal-title":"Genes Dev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/viro.1997.8804","article-title":"Characterization of cucumber mosaic virus IV. Movement protein and coat protein are both essential for cell-to-cell movement of cucumber mosaic virus","volume":"237","author":"Canto","year":"1997","journal-title":"Virology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1094\/PDIS-02-10-0124","article-title":"Potato virus Y: An evolving concern for potato crops in the United States and Canada","volume":"94","author":"Gray","year":"2010","journal-title":"Plant Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/0022-1317-73-1-1","article-title":"Highlights and prospects of potyvirus molecular biology","volume":"73","author":"Riechmann","year":"1992","journal-title":"J. Gen. Virol."},{"key":"ref_31","unstructured":"Nichol, S.T., Beaty, B.J., Elliott, R.M., Goldbach, R., Plyusnin, A., Schmaljohn, C.S., and Tesh, R.B. (2005). VIIIth report of the International Committee on Taxonomy of Viruses, Elsevier."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1073\/pnas.0800468105","article-title":"An overlapping essential gene in the Potyviridae","volume":"105","author":"Chung","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","first-page":"3125","article-title":"Detection and molecular variation of Potato virus Y CP gene in China","volume":"46","author":"Gao","year":"2013","journal-title":"Sci. Agric. Sin."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1743-422X-8-207","article-title":"Differential pathogenicity of two different recombinant PVY(NTN) isolates in Physalis floridana is likely determined by the coat protein gene","volume":"8","author":"Hu","year":"2011","journal-title":"Virol. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.virusres.2007.09.010","article-title":"Genetic structure of a population of Potato virus Y inducing potato tuber necrotic ringspot disease in Japan; comparison with North American and European populations","volume":"131","author":"Ogawa","year":"2008","journal-title":"Virus Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"eaaw3808","DOI":"10.1126\/sciadv.aaw3808","article-title":"Structural basis for the multitasking nature of the potato virus Y coat protein","volume":"5","author":"Coll","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1099\/vir.0.064220-0","article-title":"Molecular and cellular mechanisms underlying potyvirus infection","volume":"95","author":"Ivanov","year":"2014","journal-title":"J. Gen. Virol."},{"key":"ref_38","first-page":"549","article-title":"Long-distance movement factor: A transport function of the Potyvirus helper component proteinase","volume":"7","author":"Cronin","year":"1995","journal-title":"Plant Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/viro.1997.8777","article-title":"Capsid protein and helper component-proteinase function as potyvirus cell-to-cell movement proteins","volume":"237","author":"Rojas","year":"1997","journal-title":"Virology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1073\/pnas.95.22.13079","article-title":"A viral suppressor of gene silencing in plants","volume":"95","author":"Anandalakshmi","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e01320-18","DOI":"10.1128\/JVI.01320-18","article-title":"Dynamin-like proteins of endocytosis in plants are coopted by potyviruses to enhance virus infection","volume":"92","author":"Wu","year":"2018","journal-title":"J. Virol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1128\/jvi.71.11.8624-8631.1997","article-title":"VPg of tobacco etch potyvirus is a host genotype-specific determinant for long-distance movement","volume":"71","author":"Schaad","year":"1997","journal-title":"J. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1099\/jgv.0.000740","article-title":"ICTV Virus Taxonomy Profile: Potyviridae","volume":"98","author":"Wylie","year":"2017","journal-title":"J. Gen. Virol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/nar\/gkx932","article-title":"Virus taxonomy: The database of the International Committee on Taxonomy of Viruses (ICTV)","volume":"46","author":"Lefkowitz","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s42483-021-00101-1","article-title":"A clade of telosma mosaic virus from Thailand is undergoing geographical expansion and genetic differentiation in passionfruit of Vietnam and China","volume":"3","author":"Yu","year":"2021","journal-title":"Phytopathol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e0144422","DOI":"10.1128\/jvi.01444-22","article-title":"A zinc finger motif in the P1 N terminus, highly conserved in a subset of potyviruses, is associated with the host range and fitness of telosma mosaic virus","volume":"97","author":"Gou","year":"2023","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tplants.2005.11.004","article-title":"Translation initiation factors: A weak link in plant RNA virus infection","volume":"11","author":"Robaglia","year":"2006","journal-title":"Trends Plant Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s00705-017-3358-5","article-title":"Changes to taxonomy and the international code of virus classification and nomenclature ratified by the international committee on taxonomy of viruses","volume":"162","author":"Adams","year":"2017","journal-title":"Arch. Virol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1364-3703.2011.00752.x","article-title":"Top 10 plant viruses in molecular plant pathology","volume":"12","author":"Scholthof","year":"2011","journal-title":"Mol. Plant Pathol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev-virology-100114-055036","article-title":"The genus tospovirus: Emerging bunyaviruses that threaten food security","volume":"3","author":"Oliver","year":"2016","journal-title":"Annu. Rev. Virol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev-phyto-080615-095843","article-title":"Resistance to tospoviruses in vegetable crops: Epidemiological and molecular aspects","volume":"54","author":"Turina","year":"2016","journal-title":"Annu. Rev. Phytopathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.coviro.2015.08.003","article-title":"Thrips transmission of tospoviruses","volume":"15","author":"Rotenberg","year":"2015","journal-title":"Curr. Opin. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-5793(02)03632-3","article-title":"Identification of a novel RNA silencing suppressor, NSs protein of Tomato spotted wilt virus","volume":"532","author":"Takeda","year":"2002","journal-title":"FEBS Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1099\/vir.0.81827-0","article-title":"Viral suppressors of RNA interference impair RNA silencing induced by a Semliki forest virus replicon in tick cells","volume":"87","author":"Garcia","year":"2006","journal-title":"J. Gen. Virol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1074\/jbc.M114.604678","article-title":"Structure and function analysis of nucleocapsid protein of tomato spotted wilt virus interacting with RNA using homology modeling","volume":"290","author":"Li","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e00892-17","DOI":"10.1128\/JVI.00892-17","article-title":"Distinct mechanism for the formation of the ribonucleoprotein complex of tomato spotted wilt virus","volume":"91","author":"Guo","year":"2017","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1073\/pnas.96.1.55","article-title":"Homotypic interaction and multimerization of nucleocapsid protein of tomato spotted wilt tospovirus: Identification and characterization of two interacting domains","volume":"96","author":"Uhrig","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1105\/tpc.113.114298","article-title":"The cytosolic nucleoprotein of the plant-infecting bunyavirus tomato spot-ted wilt recruits endoplasmic reticulum-resident proteins to endoplasmic re-ticulum export sites","volume":"25","author":"Ribeiro","year":"2013","journal-title":"Plant Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.virol.2008.09.028","article-title":"Tomato spotted wilt virus nucleocapsid protein interacts with both viral glycoproteins Gn and Gc in planta","volume":"383","author":"Ribeiro","year":"2009","journal-title":"Virology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s11434-008-0467-2","article-title":"Southern rice black-streaked dwarf virus: A new proposed Fijivirus species in the family Reoviridae","volume":"53","author":"Zhou","year":"2008","journal-title":"Chin. Sci. Bull."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1094\/PDIS-07-10-0535","article-title":"Identification, characterization, and distribution of southern rice black-streaked dwarf virus in Vietnam","volume":"95","author":"Hoang","year":"2011","journal-title":"Plant Dis."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Zhou, G., Xu, D., Xu, D., and Zhang, M. (2013). Southern rice black-streaked dwarf virus: A white-backed planthopper-transmitted Fijivirus threatening rice production in Asia. Front. Microbiol., 4.","DOI":"10.3389\/fmicb.2013.00270"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1007\/s00705-012-1430-8","article-title":"Methodology for antibody preparation and detection of southern rice black-streaked dwarf virus","volume":"157","author":"Chen","year":"2012","journal-title":"Arch. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yu, L., Jin, L., Wang, W., Zhao, Q., Ran, L., Li, X., Chen, Z., Guo, R., and Wei, Y. (2017). Evaluation of rice resistance to southern rice black-streaked dwarf virus and rice ragged stunt virus through combined field tests, quantitative real-time PCR, and proteome analysis. Viruses, 9.","DOI":"10.3390\/v9020037"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1439-0434.2010.01679.x","article-title":"The complete genome sequence of two isolates of Southern rice black-streaked dwarf virus, a new member of the genus Fijivirus","volume":"158","author":"Wang","year":"2010","journal-title":"J. Phytopathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pep.2015.04.003","article-title":"Characterization of the importance of terminal residues for southern rice black-streaked dwarf virus P9-1 viroplasm formations","volume":"111","author":"Li","year":"2015","journal-title":"Protein Expr. Purif."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/ppa.12630","article-title":"Biology of Southern rice black-streaked dwarf virus: A novel fijivirus emerging in East Asia","volume":"66","author":"Lv","year":"2017","journal-title":"Plant Pathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00705-008-0209-4","article-title":"A black-streaked dwarf disease on rice in China is caused by a novel Fijivirus","volume":"153","author":"Zhang","year":"2008","journal-title":"Arch. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.ijbiomac.2017.05.059","article-title":"Interaction research on an antiviral molecule that targets the coat protein of Southern rice black-streaked dwarf virus","volume":"103","author":"Ran","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, Z., Feng, A., Cui, M., Liu, Y., Wang, L., and Wang, Q. (2012). First discovery and stucture-activity relationship study of phenanthroquinolizidines as novel antiviral agents against tobacco mosaic virus (TMV). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0052933"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1021\/jf3013376","article-title":"Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines","volume":"60","author":"Wang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.bmcl.2005.02.022","article-title":"Selective interaction between tylophorine B and bulged DNA","volume":"15","author":"Xi","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1016\/j.bmcl.2006.05.059","article-title":"The interaction between tylophorine B and TMV RNA","volume":"16","author":"Xi","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/cbic.201200313","article-title":"Antofine analogues can inhibit tobacco mosaic virus assembly through small-molecule-RNA interactions","volume":"13","author":"Gao","year":"2012","journal-title":"Chembiochem"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ps.4008","article-title":"Design, synthesis, antiviral activity and mode of action of phenanthrene-containing N-heterocyclic compounds inspired by the phenanthroindolizidine alkaloid antofine","volume":"72","author":"Yu","year":"2016","journal-title":"Pest Manag. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/cbic.202100138","article-title":"A H2 S-specific ultrasensitive fluorogenic probe reveals TMV-Induced H2 S production to limit virus replication","volume":"22","author":"Pang","year":"2021","journal-title":"Chembiochem"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1073\/pnas.0702398104","article-title":"Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses","volume":"104","author":"Li","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1021\/acs.jafc.4c00992","article-title":"Aloperine-type alkaloids with antiviral and antifungal activities from the seeds of Sophora alopecuroides L.","volume":"72","author":"Hu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"24942","DOI":"10.1039\/C9RA05349B","article-title":"Biological activity evaluation and action mechanism of chalcone derivatives containing thiophene sulfonate","volume":"9","author":"Guo","year":"2019","journal-title":"RSC Adv."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mao, P., Xing, L., He, B., Deng, T., Qin, Y., Hu, Y., An, Y., and Xue, W. (Mol. Divers., 2024). Antiviral activity evaluation and action mechanism of chalcone derivatives containing phenoxypyridine, Mol. Divers., advance online publication.","DOI":"10.1007\/s11030-024-10843-7"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1021\/acs.jafc.1c07805","article-title":"Discovery of phytoalexin camalexin and its derivatives as novel antiviral and antiphytopathogenic-fungus agents","volume":"70","author":"Liao","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"10316","DOI":"10.1021\/acs.jafc.2c03632","article-title":"Discovery of novel \u03b1-methylene-\u03b3-butyrolactone derivatives containing vanillin moieties as antiviral and antifungal agents","volume":"70","author":"He","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1104\/pp.71.4.896","article-title":"Gramine accumulation in leaves of barley grown under high-temperature stress","volume":"71","author":"Hanson","year":"1983","journal-title":"Plant Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1021\/acs.jafc.8b06859","article-title":"Natural products for drug discovery: Discovery of gramines as novel agents against a plant virus","volume":"67","author":"Lu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"19721","DOI":"10.1021\/acsomega.0c02421","article-title":"Design, synthesis, antiviral bioactivity, and mechanism of the ferulic acid ester-containing sulfonamide moiety","volume":"5","author":"Ren","year":"2020","journal-title":"ACS Omega"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"14610","DOI":"10.1021\/acs.jafc.4c03713","article-title":"Ferulic acid dimers as potential antiviral agents by inhibiting TMV self-assembly","volume":"72","author":"Tai","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"30826","DOI":"10.1021\/acsomega.1c05256","article-title":"Design, synthesis, antibacterial activity, antiviral activity, and mechanism of myricetin derivatives containing a quinazolinone moiety","volume":"6","author":"Liu","year":"2021","journal-title":"ACS Omega"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3987\/COM-97-S65","article-title":"Two new pyrroloquinazolinoquinoline alkaloids from Peganum nigellastrum","volume":"46","author":"Nomura","year":"1997","journal-title":"Heterocycles"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"8764","DOI":"10.1021\/acs.jafc.0c04278","article-title":"Luotonin A and its derivatives as novel antiviral and antiphytopathogenic fungus agents","volume":"68","author":"Hao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Chen, S., Yang, Z., Sun, W., Tian, K., Sun, P., and Wu, J. (2024). TMV-CP based rational design and discovery of \u03b1-Amide phosphate derivatives as anti plant viral agents. Bioorg. Chem., 147.","DOI":"10.1016\/j.bioorg.2024.107415"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ijbiomac.2016.10.027","article-title":"Binding interactions between enantiomeric \u03b1-aminophosphonate derivatives and tobacco mosaic virus coat protein","volume":"94","author":"Zhang","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11350","DOI":"10.1021\/acs.jafc.0c04868","article-title":"Marine natural product for pesticide candidate: Pulmonarin alkaloids as novel antiviral and anti-phytopathogenic-fungus agents","volume":"68","author":"Zhang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1002\/ps.6510","article-title":"Pityriacitrin marine alkaloids as novel antiviral and anti-phytopathogenic-fungus agents","volume":"77","author":"Wang","year":"2021","journal-title":"Pest Manag. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1021\/acs.jafc.2c00664","article-title":"Marine sesquiterpenes for plant protection: Discovery of laurene sesquiterpenes and their derivatives as novel antiviral and antiphytopathogenic fungal agents","volume":"70","author":"Ding","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"15693","DOI":"10.1021\/acs.jafc.2c05898","article-title":"Structural optimization of the natural product: Discovery of almazoles C-D and their derivatives as novel antiviral and anti-phytopathogenic fungus agents","volume":"70","author":"Yuan","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Yan, L., Gao, Y., Li, T., Wang, X., Xie, R., Liu, Y., Xie, Y., Wang, Z., Lu, A., and Wang, Q. (2023). Design, synthesis, antiviral and fungicidal activities of novel polycarpine simplified analogues. Bioorg. Chem., 135.","DOI":"10.1016\/j.bioorg.2023.106508"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Pandey, K.P., Rahman, M.T., and Cook, J.M. (2021). Bisindole alkaloids from the Alstonia species: Recent isolation, bioactivity, biosynthesis, and synthesis. Molecules, 26.","DOI":"10.3390\/molecules26113459"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Gao, Y., He, X., Yan, L., Zhang, H., Liu, S., Ma, Q., Zhang, P., Zhang, Y., Zhang, Z., and Wang, Z. (2023). Discovery of barakacin and its derivatives as novel antiviral and fungicidal agents. Molecules, 28.","DOI":"10.3390\/molecules28073032"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1021\/acs.jafc.3c01247","article-title":"Discovery of chiral diamine derivatives containing 1,2-diphenylethylenediamine as novel antiviral and fungicidal agents","volume":"71","author":"Yang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ja.2008.124","article-title":"Essramycin: A first triazolopyrimidine antibiotic isolatedfrom nature","volume":"61","author":"Shaaban","year":"2008","journal-title":"J. Antibiot."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1021\/np100298m","article-title":"A short synthesis of the triazolopyrimidine antibiotic essramycin","volume":"73","author":"Battaglia","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1021\/np100648q","article-title":"Synthesis of essramycin and comparison of its antibacterial activity","volume":"73","author":"Tee","year":"2010","journal-title":"J. Nat. Prod."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/acs.jafc.9b06006","article-title":"Discovery, structural optimization, and mode of action of essramycin alkaloid and its derivatives as anti-tobacco mosaic virus and anti-phytopathogenic fungus agents","volume":"68","author":"Wang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"10093","DOI":"10.1021\/acs.jafc.1c04098","article-title":"Structural simplification of marine natural products: Discovery of hamacanthin derivatives containing indole and piperazinone as novel antiviral and anti-phytopathogenic-fungus agents","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.pestbp.2014.04.008","article-title":"Induction of systemic resistance against tobacco mosaic virus by Ningnanmycin in tobacco","volume":"111","author":"Han","year":"2014","journal-title":"Pestic. Biochem. Phy."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1094\/PHYTO-09-20-0382-R","article-title":"Antifungal activity and possible mode of action of Ningnanmycin against tea gray blight disease pathogen Pseudopestalotiopsis camelliae-sinensis","volume":"111","author":"Yang","year":"2021","journal-title":"Phytopathology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"82446","DOI":"10.18632\/oncotarget.19401","article-title":"Ningnanmycin inhibits tobacco mosaic virus virulence by binding directly to its coat protein discs","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/S0040-4039(00)86237-1","article-title":"Structure elucidation of streptindole, a novel genotoxic metabolite isolated from intestinal bacteria","volume":"24","author":"Osawa","year":"1983","journal-title":"Tetrahedron Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1016\/j.bmc.2008.09.070","article-title":"Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group","volume":"16","author":"Ouyang","year":"2008","journal-title":"Bioorgan. Med. Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1016\/j.bmcl.2015.07.068","article-title":"Antiviral activity and interaction mechanisms study of novel glucopyranoside derivatives","volume":"25","author":"Chen","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.bmcl.2018.06.049","article-title":"Pyrazolo [3,4-d]pyrimidine derivatives containing a Schiff base moiety as potential antiviral agents","volume":"28","author":"Wang","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Chen, L., Wang, X., Tang, X., Xia, R., Guo, T., Zhang, C., Li, X., and Xue, W. (2019). Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold. BMC Chem., 13.","DOI":"10.1186\/s13065-019-0547-1"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"22596","DOI":"10.1021\/acsomega.0c03306","article-title":"Discovery of dithioacetal derivatives containing sulfonamide moiety of novel antiviral agents by TMV coat protein as a potential target","volume":"5","author":"Yang","year":"2020","journal-title":"ACS Omega"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Wu, Z., Yang, W., Hou, S., Xie, D., Yang, J., Liu, L., and Yang, S. (2021). In vivo antiviral activity and disassembly mechanism of novel 1-phenyl-5-amine-4-pyrazole thioether derivatives against tobacco mosaic virus. Pestic. Biochem. Phys., 173.","DOI":"10.1016\/j.pestbp.2021.104771"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1002\/ps.7623","article-title":"Discovery of novel phenothiazine derivatives as new agrochemical alternatives for treating plant viral diseases","volume":"79","author":"Shao","year":"2023","journal-title":"Pest Manag. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"6900","DOI":"10.1021\/acs.jafc.3c06806","article-title":"Identification of novel bisamide-decorated benzotriazole derivatives as anti-phytopathogenic virus agents: Bioactivity evaluation and computational simulation","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"He, B., Hu, Y., Qin, Y., Zhang, Y., Luo, X., Wang, Z., and Xue, W. (Mol. Divers., 2024). Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety, Mol. Divers., online ahead of print.","DOI":"10.1007\/s11030-024-10894-w"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Gong, C., Meng, K., Sun, Z., Zeng, W., An, Y., Zou, H., Qiu, Y., Liu, D., and Xue, W. (2024). Flavonol derivatives containing a quinazolinone moiety: Design, synthesis, and antiviral activity. Chem. Biodivers., 21.","DOI":"10.1002\/cbdv.202301737"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s11030-023-10631-9","article-title":"Antiviral activity evaluation and action mechanism of myricetin derivatives containing thioether quinoline moiety","volume":"28","author":"Wang","year":"2024","journal-title":"Mol. Divers."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"105812","DOI":"10.1016\/j.fitote.2023.105812","article-title":"Myricetin derivatives containing the benzoxazinone moiety discovered as potential anti-tobacco mosaic virus agents","volume":"173","author":"Yuan","year":"2024","journal-title":"Fitoterapia"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0040-4039(98)02296-5","article-title":"Iheyamines, new cytotoxic bisindole pigments from a colonial ascidian, Polycitorella sp.","volume":"40","author":"Sasaki","year":"1999","journal-title":"Tetrahedron Lett."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Guo, X., Zhang, P., Chen, M., Li, T., Hou, C., Que, X., Xu, L., Zhou, Z., Wang, Q., and Wang, Z. (2024). Synthesis, structural modification, and biological activity of a novel bisindole alkaloid iheyamine A. Bioorg. Chem., 153.","DOI":"10.1016\/j.bioorg.2024.107757"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1021\/acs.jafc.0c02101","article-title":"Discovery of tryptanthrins as novel antiviral and anti-phytopathogenic-fungus agents","volume":"68","author":"Hao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1002\/ps.6569","article-title":"Identification of anti-TMV active flavonoid glycosides and their mode of action on virus particles from Clematis lasiandra Maxim","volume":"77","author":"Li","year":"2021","journal-title":"Pest Manag. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1021\/acs.jafc.1c03714","article-title":"Toad alkaloid for pesticide discovery: Dehydrobufotenine derivatives as novel agents against plant virus and fungi","volume":"69","author":"Tian","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.freeradbiomed.2010.07.017","article-title":"Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system","volume":"49","author":"Shih","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Li, T., Liu, S., Guo, X., He, X., Lu, A., Wang, Q., and Wang, Z. (2024). Design, synthesis, and biological activities of arecoline derivatives containing 1,3,4-oxadiazole structure. Bioorg. Chem., 151.","DOI":"10.1016\/j.bioorg.2024.107708"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ps.5115","article-title":"Synthesis, bioactivity and mode of action of 5A 5B 6C tricyclic spirolactones as novel antiviral lead compounds","volume":"75","author":"Zhu","year":"2019","journal-title":"Pest Manag. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1016\/S0040-4039(01)99550-4","article-title":"A new sesquiterpene hydrocarbro from Laurbficia glaivdulif","volume":"40","author":"Irie","year":"1965","journal-title":"Tetrahedron Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1021\/acs.jafc.3c03700","article-title":"Design, synthesis, and biological evaluation of novel derivatives of the marine natural product laurene","volume":"71","author":"Xu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pestbp.2017.06.005","article-title":"Label-free quantitative proteomics analysis of Cytosinpeptidemycin responses in southern rice black-streaked dwarf virus-infected rice","volume":"147","author":"Yu","year":"2018","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Chen, J.G., Liu, H., Xia, Z.H., Zhao, X.X., Wu, Y.H., and An, M.N. (2019). Purification and structural analysis of the effective anti-TMV compound \u03b5-poly-l-lysine produced by Streptomyces ahygroscopicus. Molecules, 24.","DOI":"10.3390\/molecules24061156"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7738","DOI":"10.1021\/acs.jafc.9b02662","article-title":"A novel biological agent Cytosinpeptidemycin inhibited the pathogenesis of tobacco mosaic virus by inducing host resistance and stress response","volume":"67","author":"An","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"18952","DOI":"10.1039\/C8RA01466C","article-title":"Binding studies between cytosinpeptidemycin and the superfamily 1 helicase protein of tobacco mosaic virus","volume":"8","author":"Li","year":"2018","journal-title":"RSC Adv."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Wang, C., Ma, G., Zhang, S., Zhao, K., and Li, X. (2023). Study on the binding of ningnanmycin to the helicase of Tobamovirus virus. Pestic. Biochem. Phy., 194.","DOI":"10.1016\/j.pestbp.2023.105494"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Wang, D., Huang, M., Gao, D., Chen, K., Xie, X., Xu, W., and Li, X. (2020). Screening anti-TMV agents targeting tobacco mosaic virus helicase protein. Pestic. Biochem. Phy., 166.","DOI":"10.1016\/j.pestbp.2019.07.017"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Li, Z., Yang, B., Liu, H., Ding, Y., Fang, Z., Shao, W., Qi, P., Zhou, X., Liu, L., and Yang, S. (2022). The discovery of novel ferulic acid derivatives incorporating substituted isopropanolamine moieties as potential tobacco mosaic virus helicase inhibitors. Int. J. Biol. Macromol., 23.","DOI":"10.3390\/ijms232213991"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1002\/ps.7147","article-title":"Antiviral modes of action of the novel compound GLY-15 containing pyrimidine heterocycle and moroxydine skeleton against tobacco mosaic virus","volume":"78","author":"Yu","year":"2022","journal-title":"Pest Manag. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1002\/ps.7592","article-title":"Discovery of phosphonate derivatives containing different substituted 1,2,3-triazole motif as promising tobacco mosaic virus (TMV) helicase inhibitors for controlling plant viral diseases","volume":"79","author":"Li","year":"2023","journal-title":"Pest Manag. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3987\/COM-05-10488","article-title":"Synthesis of some heterocycle containing urea derivatives and their anti-viral activity","volume":"68","author":"Singh","year":"2006","journal-title":"Heterocycles"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1021\/jm020057r","article-title":"Pyrazole urea-based inhibitors of p38 MAP kinase: From lead compound to clinical candidate","volume":"45","author":"Regan","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Bai, Q., Jiang, J., Luo, D., Huang, Y., Huang, M., Zhao, G., Wang, Z., and Li, X. (2023). Cysteine protease domain of potato virus Y: The potential target for urea derivatives. Pestic. Biochem. Phys., 189.","DOI":"10.1016\/j.pestbp.2022.105309"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.pestbp.2019.01.004","article-title":"Cucumber mosaic virus coat protein: The potential target of 1, 4-pentadien-3-one derivatives","volume":"155","author":"Li","year":"2019","journal-title":"Pestic. Biochem. Phys."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"15360","DOI":"10.1021\/acs.jafc.2c05536","article-title":"Myricetin derivative LP11 targets cucumber mosaic virus 2b protein to achieve in vivo antiviral activity in plants","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"e2309343","DOI":"10.1002\/advs.202309343","article-title":"Innovative arylimidazole-fused phytovirucides via carbene-catalyzed [3+4] cycloaddition: Locking viral cell-to-cell movement by out-competing virus capsid-host interactions","volume":"11","author":"Wei","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1002\/ps.7428","article-title":"Development of axially chiral urazole scaffolds for antiplant virus applications against potato virus Y","volume":"79","author":"Jin","year":"2023","journal-title":"Pest Manag. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1002\/ps.8149","article-title":"Design, synthesis and anti-PVY activity of planar chiral thiourea derivatives incorporated with [2.2]Paracyclophane","volume":"80","author":"Shu","year":"2024","journal-title":"Pest Manag. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1021\/acs.jafc.4c01306","article-title":"Tryptanthrin derivative B1 binds viral genome-linked protein (VPg) of potato virus Y","volume":"72","author":"Wu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"13645","DOI":"10.1021\/acs.jafc.3c02823","article-title":"Synthesis and screening of chemical agents targeting viral protein genome-linked protein of telosma mosaic virus","volume":"71","author":"Zhao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"6015","DOI":"10.1021\/acs.jafc.2c00773","article-title":"Design, synthesis, anti-tomato spotted wilt virus activity, and mechanism of action of thienopyrimidine-containing dithioacetal derivatives","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"10819","DOI":"10.1021\/acs.jafc.1c03626","article-title":"Discovery of novel chromone derivatives as potential anti-TSWV agents","volume":"69","author":"Zan","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Jiang, D.H., Zhang, J., He, H.F., Li, J., Hu, D.Y., and Song, B.A. (2021). Discovery of novel chromone derivatives containing a sulfonamide moiety as potential anti-TSWV agents. Bioorg. Med. Chem. Lett., 53.","DOI":"10.1016\/j.bmcl.2021.128431"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"105140","DOI":"10.1016\/j.fitote.2022.105140","article-title":"Thermlanseedlines A-G, seven thermopsine-based alkaloids with antiviral and insecticidal activities from the seeds of Thermopsis lanceolata R. Br","volume":"158","author":"Zhang","year":"2022","journal-title":"Fitoterapia"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1021\/acs.jafc.2c09003","article-title":"Matrine-Type alkaloids with anti-tomato spotted wilt virus activity from the root of Sophora tonkinensis Gagnep","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3390\/v7031454","article-title":"Interaction research on the antiviral molecule dufulin targeting on southern rice black streaked dwarf virus p9-1 nonstructural protein","volume":"7","author":"Wang","year":"2015","journal-title":"Viruses"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"114402","DOI":"10.1016\/j.jviromet.2021.114402","article-title":"Insights into a rapid screening method for anti-cucumber mosaic virus compounds","volume":"301","author":"Yan","year":"2022","journal-title":"J. Virol. Methods"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2016.09.013","article-title":"Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper","volume":"227","author":"Ryu","year":"2017","journal-title":"Virus Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.virusres.2010.12.004","article-title":"Development of infectious transcripts from full-length and GFP-tagged cDNA clones of pepper mottle virus and stable systemic expression of GFP in tobacco and pepper","volume":"155","author":"Lee","year":"2011","journal-title":"Virus Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1021\/acs.jafc.2c00659","article-title":"Defense mechanism of Capsicum annuum L. infected with pepper mild mottle virus induced by vanisulfane","volume":"70","author":"Shi","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Li, X., Song, B., Chen, X., Wang, Z., Zeng, M., Yu, D., Hu, D., Chen, Z., Jin, L., and Yang, S. (2013). Crystal structure of a four-layer aggregate of engineered TMV CP implies the importance of terminal residues for oligomer assembly. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0077717"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/1743-422X-9-279","article-title":"The development and application of new crystallization method for tobacco mosaic virus coat protein","volume":"9","author":"Li","year":"2012","journal-title":"Virol. J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Chen, J., Luo, X., Chen, Y., Wang, Y., Peng, J., and Xing, Z. (2022). Recent research progress: Discovery of anti-plant virus agents based on natural scaffold. Front. Chem., 10.","DOI":"10.3389\/fchem.2022.926202"}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/12\/1654\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:58:27Z","timestamp":1760115507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/15\/12\/1654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":162,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["genes15121654"],"URL":"https:\/\/doi.org\/10.3390\/genes15121654","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,23]]}}}