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Methods: Clinical data were collected from 5433 coal mine workers to compare the incidence of dyslipidemia between the dust-exposed group and the non-exposed group. A mouse model of silicon dioxide exposure was established to observe hepatic fat accumulation and pathological changes. Liver tissue sequencing was performed to screen for key differential genes. In vitro cell experiments were utilized to identify the molecular mechanisms underlying hepatocyte metabolic abnormalities induced by silicon dioxide exposure. Results: Clinical data revealed that 69.2% of miners in the dust-exposed group developed dyslipidemia, which was higher than the 30.7% in the non-exposed group. Animal data showed that silicon dioxide exposure led to hepatic fat deposition and pathological damage, with the degree of injury positively correlated with exposure time. Liver sequencing identified a significant upregulation of the FMO3 (flavin monooxygenase 3) gene in mouse liver tissue following silicon dioxide exposure, accompanied by enhanced inflammatory responses. Mechanistic studies demonstrated that silicon dioxide activates Kupffer cells to secrete IL-6 (interleukin-6), which induces high expression of FMO3 in hepatocytes through the PKC\/YY1 signaling pathway, thereby disrupting lipid metabolism. Conclusions: Silicon dioxide exposure can promote the upregulation of FMO3 expression in hepatocytes by activating Kupffer cells to release IL-6 via the PKC\/YY1 pathway, ultimately leading to lipid metabolic disorders and dyslipidemia<\/jats:p>","DOI":"10.3390\/genes16040456","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T08:09:17Z","timestamp":1744790957000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC\/YY1 Signaling Pathway"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5118-6461","authenticated-orcid":false,"given":"Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"},{"name":"Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan 232001, China"},{"name":"Anhui Province Engineering Laboratory of Occupational Health and Safety, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"},{"name":"Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6723-0490","authenticated-orcid":false,"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"},{"name":"Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan 232001, China"},{"name":"Anhui Province Engineering Laboratory of Occupational Health and Safety, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangliang","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuansheng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Huainan 232001, China"},{"name":"Anhui Province Engineering Laboratory of Occupational Health and Safety, Huainan 232001, China"},{"name":"Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and Technology, Huainan 232001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"ref_1","unstructured":"(2023). 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