{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:53:56Z","timestamp":1773712436954,"version":"3.50.1"},"reference-count":64,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Pancreatic ductal adenocarcinoma (PDAC), a challenging and malignant cancer, primarily originates from the exocrine cells of the pancreas. The superfamily of solute carrier (SLC) transporters, consisting of more than 450 proteins divided into 65 families, is integral to various cellular processes and represents a promising target in precision oncology. As therapeutic targets, SLC transporters are explored through an integrative analysis. Materials and Methods: The expression profiles of SLCs were systematically analyzed using mRNA data from The Cancer Genome Atlas (TCGA) and protein data from the Human Protein Atlas (HPA). Survival analysis was examined to evaluate the prognostic significance of SLC transporters for overall survival (OS) and disease-specific survival (DSS). Genetic alterations were examined using cBioPortal, while structural studies were performed with AlphaFold and AlphaMissense to predict functional impacts. Furthermore, Gene Set Enrichment Analysis (GSEA) was carried out to identify oncogenic pathways linked to SLC transporter expression. Results: SLC transporters were significantly upregulated in tumors relative to normal tissues. Higher expression levels of SLC39A10 (HR = 1.89, p = 0.0026), SLC22B5 (HR = 1.84, p = 0.0042), SLC55A2 (HR = 2.15, p = 0.00023), and SLC30A6 (HR = 1.90, p = 0.003) were strongly associated with unfavorable OS, highlighting their connection to poor prognosis in PDAC. GSEA highlighted that these four transporters are significantly involved in key oncogenic pathways, such as epithelial\u2013mesenchymal transition (EMT), TNF-\u03b1 signaling, and angiogenesis. Conclusions: The study identifies four SLCs as therapeutic targets in PDAC, highlighting their crucial role in essential metabolic pathways. These findings lay the groundwork for developing next-generation metabolic anti-cancer treatment to improve survival for PDAC patients.<\/jats:p>","DOI":"10.3390\/genes16040463","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T06:23:56Z","timestamp":1744957436000},"page":"463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Solute Carrier Superfamily as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-9691","authenticated-orcid":false,"given":"Sang Yeon","family":"Cho","sequence":"first","affiliation":[{"name":"Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon 34134, Republic of Korea"},{"name":"CHOMEDICINE Inc., TIPS Town, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0485-0072","authenticated-orcid":false,"given":"Hyuk Soo","family":"Eun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea"},{"name":"Department of Internal Medicine, Chungnam National University Hospital, Daejeon 35015, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-0280","authenticated-orcid":false,"given":"Jaejeung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, Chungnam National University, Daejeon 34134, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Dam","family":"Ko","sequence":"additional","affiliation":[{"name":"Seoul Teunteun Rehabilitation Clinic, Jeungpyeong-gun, Chungcheongbuk-do 27937, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-2660","authenticated-orcid":false,"given":"Woo Sun","family":"Rou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea"},{"name":"Department of Internal Medicine, Chungnam National University Sejong Hospital, Sejong 30099, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Seok","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea"},{"name":"Department of Internal Medicine, Chungnam National University Sejong Hospital, Sejong 30099, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41568-021-00418-1","article-title":"Pancreatic cancer evolution and heterogeneity: Integrating omics and clinical data","volume":"22","author":"Connor","year":"2022","journal-title":"Nat. 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