{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:43:59Z","timestamp":1787028239098,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guizhou Province","award":["[2023]007"],"award-info":[{"award-number":["[2023]007"]}]},{"name":"Science and Technology Program of Guizhou Province","award":["GZZYCCYJSTX-02"],"award-info":[{"award-number":["GZZYCCYJSTX-02"]}]},{"name":"Modern Agricultural Industrial Technology System for Chinese Medicinal Materials in Guizhou Province","award":["[2023]007"],"award-info":[{"award-number":["[2023]007"]}]},{"name":"Modern Agricultural Industrial Technology System for Chinese Medicinal Materials in Guizhou Province","award":["GZZYCCYJSTX-02"],"award-info":[{"award-number":["GZZYCCYJSTX-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Objective: To explore the efficacy and mechanism of Coix seeds in treating herpes zoster (HZ) using an integrated computational approach. Methods: Network pharmacology, molecular docking, and machine learning were employed. Disease-related targets were collected from multiple databases, and intersection targets with Coix seed were analyzed via PPI, GO, and KEGG enrichment. A \u201cTCM-Ingredient-Target\u201d network was constructed using Cytoscape. Molecular docking and dynamics simulations were performed for validation. Results: Fifty-five overlapping targets were identified, with core targets including TNF, EGF, and GAPDH. Enrichment analysis revealed key pathways such as inflammation and immune regulation. Molecular docking confirmed strong binding affinity between active compounds and targets. Conclusions: This study demonstrates that Coix seed exerts anti-HZ effects through multi-target mechanisms, providing a theoretical basis for developing novel multi-pathway treatment strategies.<\/jats:p>","DOI":"10.3390\/genes16050580","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:22:17Z","timestamp":1747225337000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Multi-Target Synergistic Mechanism of Coix Seed Therapy for Herpes Zoster Based on Machine Learning and Network Pharmacology"],"prefix":"10.3390","volume":"16","author":[{"given":"Zhiqin","family":"Song","sequence":"first","affiliation":[{"name":"Institute of Crop Germplasm Resources\/Institute of Modern Chinese Herbal Medicines, Guizhou Academy of Agricultural Sciences, Guiyang 550006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Crop Germplasm Resources\/Institute of Modern Chinese Herbal Medicines, Guizhou Academy of Agricultural Sciences, Guiyang 550006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region, Ministry of Education, College of Life Sciences\/Institute of Agro Bioengineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region, Ministry of Education, College of Life Sciences\/Institute of Agro Bioengineering, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningxian","family":"Yang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Provincial Engineering Research Center of Ecological Food Innovation, School of Public Health, Guizhou Medical University, Guiyang 561113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"The Rural Revitalization Service Center of Guiyang City, Guiyang 550004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkai","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Crop Germplasm Resources\/Institute of Modern Chinese Herbal Medicines, Guizhou Academy of Agricultural Sciences, Guiyang 550006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e004833","DOI":"10.1136\/bmjopen-2014-004833","article-title":"Systematic review of incidence and complications of herpes zoster: Towards a global perspective","volume":"4","author":"Kawai","year":"2014","journal-title":"BMJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chen, L.K., Arai, H., Chen, L.-Y., Chou, M.-Y., Djauzi, S., Dong, B., Kojima, T., Kwon, K.T., Leong, H.N., and Leung, E.M.F. 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