{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:29:43Z","timestamp":1789439383536,"version":"build-2803163510"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background: Oral Submucous Fibrosis (OSMF) is a chronic, progressive condition characterized by the fibrosis of the oral mucosa, often associated with the habitual consumption of areca nut and tobacco, leading to significant morbidity. Despite its prevalent occurrence in many parts of the world, the underlying genetic and molecular mechanisms remain poorly understood, highlighting a critical need for research into its molecular genomics. The aim of this literature review is to investigate the molecular genomics of Oral Submucous Fibrosis by analyzing the relevant literature of the past decade. Methods: The search was conducted using MEDLINE (National Library of Medicine)-PubMed, focusing on the period 2015\u20132025 using the following keywords: Molecular Genomics AND Oral Submucous Fibrosis. This was followed by a manual search, and references were used to identify relevant articles. Results: A total of 12 articles were included in our review according to our inclusion criteria, which illustrated the importance of TGF-\u03b2, Wnt inhibitory factor-1, CypA, Hsp-70 1B, Calreticulin, Lumican, Enolase 1, MMP-2, IGF-1R, XIST, Epigallocatechin-3-gallate, Von Hippel-Lindau, and MUC1 and 4. Conclusions: Understanding the molecular pathogenesis of OSMF involves examining the molecular interactions and the roles of specific proteins. Advanced genomic technologies have opened new frontiers in the study of OSMF. As research in OSMF continues to evolve, emerging interdisciplinary approaches may provide therapeutic strategies, aiming to improve management outcomes for the patients.<\/jats:p>","DOI":"10.3390\/genes16060612","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:49:57Z","timestamp":1747903797000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Genomics of Oral Submucous Fibrosis: A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-4220","authenticated-orcid":false,"given":"Vasileios","family":"Zisis","sequence":"first","affiliation":[{"name":"Department of Oral Medicine\/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4843-6494","authenticated-orcid":false,"given":"Stefanos","family":"Zisis","sequence":"additional","affiliation":[{"name":"Clinic for Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Charisi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Poulopoulos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristeidis","family":"Sarkisian","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6611-7506","authenticated-orcid":false,"given":"Athanasios","family":"Poulopoulos","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Pathology, School of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"768","DOI":"10.25259\/IJDVL_371_20","article-title":"Oral submucous fibrosis: An overview of a challenging entity","volume":"87","author":"Gupta","year":"2021","journal-title":"Indian. J. Dermatol. Venereol. Leprol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0972-1363.195085","article-title":"Oral submucous fibrosis: A demographic study","volume":"28","author":"Kumar","year":"2016","journal-title":"J. Indian Acad. Oral Med. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.oraloncology.2005.08.005","article-title":"Oral submucous fibrosis: Review on aetiology and pathogenesis","volume":"42","author":"Tilakaratne","year":"2006","journal-title":"Oral Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1136\/bmj.324.7350.1370","article-title":"Detecting patients at a high risk of developing chronic obstructive pulmonary disease in general practice: Cross sectional case finding study","volume":"324","author":"Loozen","year":"2002","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Yang, Y.-H.C., and Warnakulasuriya, S. (2023). Lifestyle Factors, Springer.","DOI":"10.1007\/978-3-031-12855-4_8"},{"key":"ref_6","first-page":"61","article-title":"A contemporary narrative review to guide molecular epidemiology of oral submucous fibrosis","volume":"12","author":"Singh","year":"2021","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.oraloncology.2011.11.021","article-title":"Review of drug treatment of oral submucous fibrosis","volume":"48","author":"Chole","year":"2012","journal-title":"Oral Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12663-020-01507-8","article-title":"Quality of Life in Oral Submucous Fibrosis: A Systematic Review","volume":"21","author":"Chaudhry","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10006-010-0209-x","article-title":"Management of oral submucous fibrosis: An overview","volume":"14","author":"Angadi","year":"2010","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10006-010-0225-x","article-title":"Oral submucous fibrosis: A clinicopathologic review of 205 cases in Indians","volume":"15","author":"Angadi","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/jomfp.JOMFP_223_18","article-title":"A novel clinical protocol for therapeutic intervention in oral submucous fibrosis: An evidence based approach","volume":"22","author":"More","year":"2018","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fedorowicz, Z., Chan Shih-Yen, E., Dorri, M., Nasser, M., Newton, T., and Shi, L. (2008). Interventions for the management of oral submucous fibrosis. Cochrane Database Syst. Rev.","DOI":"10.1002\/14651858.CD007156"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/2229-5178.137772","article-title":"Oral submucous fibrosis and its dermatological relation","volume":"5","author":"Ali","year":"2014","journal-title":"Indian Dermatol. Online J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Pant, I., Kumar, N., Khan, I., Rao, S.G., and Kondaiah, P. (2015). Role of Areca Nut Induced TGF-\u03b2 and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129252"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.3892\/or.2015.4264","article-title":"Expression and promoter methylation of Wnt inhibitory factor-1 in the development of oral submucous fibrosis","volume":"34","author":"Zhou","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60348","DOI":"10.18632\/oncotarget.11254","article-title":"Proteomic identification of cyclophilin A as a potential biomarker and therapeutic target in oral submucous fibrosis","volume":"7","author":"Yuan","year":"2016","journal-title":"Oncotarget"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/CBM-170142","article-title":"Cyclophilin A was revealed as a candidate marker for human oral submucous fibrosis by proteomic analysis","volume":"20","author":"Hou","year":"2017","journal-title":"Cancer Biomark."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1002\/jcb.26423","article-title":"Identification of over expressed proteins in oral submucous fibrosis by proteomic analysis","volume":"119","author":"Das","year":"2018","journal-title":"J. Cell Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.1111\/jcmm.16929","article-title":"Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR","volume":"25","author":"Chen","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000526919","article-title":"Comparative Somatic Variant Analysis of a Rare Case with Concurrent Oral Leukoplakia and Oral Submucosal Fibrosis","volume":"162","author":"Anne","year":"2022","journal-title":"Cytogenet. Genome Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/odi.13811","article-title":"Genome-wide DNA methylation changes in oral submucous fibrosis","volume":"28","author":"Kundu","year":"2022","journal-title":"Oral Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jing, F., Zhu, L., Bai, J., Cai, X., Zhou, X., Zhang, J., Zhang, H., and Li, T. (2023). Molecular mechanisms underlying the epigallocatechin-3-gallate-mediated inhibition of oral squamous cell carcinogenesis. Arch. Oral Biol., 153.","DOI":"10.1016\/j.archoralbio.2023.105740"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.29271\/jcpsp.2024.03.296","article-title":"Association of Oral Submucous Fibrosis Risk with GSTM1 and GSTT1 Gene Polymorphisms","volume":"34","author":"Mannan","year":"2024","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1111\/odi.14725","article-title":"DNA methyltransferase 3A induces the occurrence of oral submucous fibrosis by promoting the methylation of the von Hippel-Lindau","volume":"30","author":"Kuang","year":"2024","journal-title":"Oral Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1007\/s00405-024-09056-3","article-title":"Quantitative proteogenomic characterization in MUC1 and MUC4 in oral squamous cell carcinoma, oral potentially malignant disorders, and normal oral mucosa in carcinogenesis","volume":"282","author":"John","year":"2025","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_26","first-page":"576","article-title":"Biochemical markers in oral submucous fibrosis: A review and update","volume":"10","author":"Kamath","year":"2013","journal-title":"Dent. Res. J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Panda, A., Mishra, P., Mohanty, A., Sundaragiri, K.S., Singh, A., and Jha, K. (2022). Is Epithelial-Mesenchymal Transition a New Roadway in the Pathogenesis of Oral Submucous Fibrosis: A Comprehensive Review. Cureus, 14.","DOI":"10.7759\/cureus.29636"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S389","DOI":"10.4103\/jcrt.jcrt_502_21","article-title":"Potentiated action on the progression of OSMF by hypoxia mediated signaling pathway by the epithelial mesenchymal transition and angiogenic apparatus","volume":"19","author":"Gupta","year":"2023","journal-title":"J. Cancer Res. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/0973-1482.98970","article-title":"Pathogenesis of oral submucous fibrosis","volume":"8","author":"Khan","year":"2012","journal-title":"J. Cancer Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4103\/jomfp.jomfp_492_22","article-title":"Role of osteopontin in oral epithelial dysplasia, oral submucous fibrosis and oral squamous cell carcinoma","volume":"27","author":"Salati","year":"2023","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12105-012-0341-z","article-title":"Evaluation of PTEN Immunoexpression in Oral Submucous Fibrosis: Role in Pathogenesis and Malignant Transformation","volume":"6","author":"Angadi","year":"2012","journal-title":"Head Neck Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/jomfp.jomfp_102_21","article-title":"Leaving no stone unturned: Role of profibrotic genes in oral submucous fibrosis\u2014A systematic review","volume":"26","author":"James","year":"2022","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41368-024-00344-6","article-title":"Oral submucous fibrosis: Pathogenesis and therapeutic approaches","volume":"17","author":"Tang","year":"2025","journal-title":"Int. J. Oral Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s10787-023-01212-1","article-title":"Polyphenol-based targeted therapy for oral submucous fibrosis","volume":"31","author":"Mehta","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_35","first-page":"3048","article-title":"Spirulina and Pentoxyfilline\u2014A Novel Approach for Treatment of Oral Submucous Fibrosis","volume":"7","author":"Mulk","year":"2013","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41368-024-00286-z","article-title":"Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis","volume":"16","author":"Yang","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/jid.jid_58_24","article-title":"Ultrasonographic Evaluation of Masseter Muscle in Patients with Oral Submucous Fibrosis","volume":"14","author":"Jaganathan","year":"2024","journal-title":"J. Interdiscip. Dent."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/6\/612\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:38:11Z","timestamp":1760031491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/6\/612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["genes16060612"],"URL":"https:\/\/doi.org\/10.3390\/genes16060612","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}