{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:12:07Z","timestamp":1784740327870,"version":"3.55.0"},"reference-count":48,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Anita and Tage Therkelsens Fund and Amalie J\u00f8rgensens Memorial Grant","award":["223-A13071-18-S68"],"award-info":[{"award-number":["223-A13071-18-S68"]}]},{"name":"Anita and Tage Therkelsens Fund and Amalie J\u00f8rgensens Memorial Grant","award":["R307-2018-3433"],"award-info":[{"award-number":["R307-2018-3433"]}]},{"name":"Danish Cancer Society (Danish Research Center for Precision Medicine in Blood Cancer","award":["223-A13071-18-S68"],"award-info":[{"award-number":["223-A13071-18-S68"]}]},{"name":"Danish Cancer Society (Danish Research Center for Precision Medicine in Blood Cancer","award":["R307-2018-3433"],"award-info":[{"award-number":["R307-2018-3433"]}]},{"name":"Lundbeck Foundation","award":["223-A13071-18-S68"],"award-info":[{"award-number":["223-A13071-18-S68"]}]},{"name":"Lundbeck Foundation","award":["R307-2018-3433"],"award-info":[{"award-number":["R307-2018-3433"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background and Objectives: Mantle cell lymphoma (MCL) is a highly heterogenous disease, but an optimal prognostic biomarker in relapsed\/refractory (R\/R) MCL has not yet been established. The circular RNA-based risk score, circSCORE, was recently proposed as a promising prognosticator in newly diagnosed, younger patients with MCL. This study explores the prognostic potential of circSCORE in R\/R MCL in both nodal (lymph node (LN)) and non-nodal tissues (bone marrow (BM)) and peripheral blood (PB)). Materials and Methods: RNA was extracted from 65 relapse samples consisting of first-relapse LN samples (n = 20) from patients who previously underwent first-line treatment in the MCL2 and MCL3 trials, and either BM (n = 34) or PB (n = 11) samples obtained from patients with R\/R MCL included in the MCL6 trial, taken at trial baseline. Kaplan\u2013Meier estimates, and Cox regressions were used to evaluate the association between circSCORE risk groups (high versus low) and outcomes. Results: Survival analyses showed significantly inferior outcomes for patients with high-risk circSCORE compared to low-risk score for both progression-free survival (PFS) (hazard ratio (HR) 1.99, p-value 0.0407) and overall survival (OS) (HR 2.29, p-value 0.0192) in the total cohort. The same tendencies were displayed when exploring the non-nodal samples only. Furthermore, circSCORE retained prognostic impact for PFS, but not OS, when adjusted for Ki67, MIPI, and TP53 mutation status. Conclusions: The circRNA-based risk score, circSCORE, displayed prognostic potential in R\/R MCL along with promising application in non-nodal tissues, indicating that circSCORE, if further validated, might serve as an easily obtainable biomarker in R\/R MCL.<\/jats:p>","DOI":"10.3390\/genes16060634","type":"journal-article","created":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T20:39:36Z","timestamp":1748205576000},"page":"634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Prognostic Potential of circSCORE in Patients with Relapsed\/Refractory Mantle Cell Lymphoma"],"prefix":"10.3390","volume":"16","author":[{"given":"Ruth","family":"Salim","sequence":"first","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Biotech Research and Innovation Centre, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-8081","authenticated-orcid":false,"given":"Christian Winther","family":"Eskelund","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Biotech Research and Innovation Centre, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Department of Oncology, Skane University Hospital, SE-221 00 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Kolstad","sequence":"additional","affiliation":[{"name":"Department of Oncology, Division Gj\u00f8vik-Lillehammer, Innlandet Hospital Trust, 2819 Gj\u00f8vik, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riikka","family":"R\u00e4ty","sequence":"additional","affiliation":[{"name":"Department of Hematology, Helsinki University Hospital, 00029 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten Utoft","family":"Niemann","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Bredo","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Raaschou-Pedersen","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences, University of Copenhagen, 1353 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Wedge","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Biotech Research and Innovation Centre, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-1781","authenticated-orcid":false,"given":"Juan Luis","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse Sommer","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Biotech Research and Innovation Centre, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-9601","authenticated-orcid":false,"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Hematology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Biotech Research and Innovation Centre, BRIC, University of Copenhagen, 2200 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/ajh.26523","article-title":"Mantle cell lymphoma in 2022\u2014A comprehensive update on molecular pathogenesis, risk stratification, clinical approach, and current and novel 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