{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:27:14Z","timestamp":1772252834996,"version":"3.50.1"},"reference-count":88,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}]},{"name":"National Heart, Lung and Blood Institute (NHLBI)","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}]},{"name":"Soifua Manuia study, labeled as \u201cNHLBI TOPMed: Genome-wide Association Study of Adiposity in Samoans\u201d","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"Northwest Genomics Center","doi-asserted-by":"publisher","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"New York Genome Center","doi-asserted-by":"publisher","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Informatics Research Center","doi-asserted-by":"publisher","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["R01-HL093093"],"award-info":[{"award-number":["R01-HL093093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["R01-HL133040"],"award-info":[{"award-number":["R01-HL133040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["T90-DE030853"],"award-info":[{"award-number":["T90-DE030853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["phs000972"],"award-info":[{"award-number":["phs000972"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["HHSN268201100037C"],"award-info":[{"award-number":["HHSN268201100037C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["HHSN268201500016C"],"award-info":[{"award-number":["HHSN268201500016C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["3R01-HL117626-02S1"],"award-info":[{"award-number":["3R01-HL117626-02S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["HHSN268201800002I"],"award-info":[{"award-number":["HHSN268201800002I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["R01-HL120393"],"award-info":[{"award-number":["R01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["U01-HL120393"],"award-info":[{"award-number":["U01-HL120393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"TOPMed Data Coordinating Center","doi-asserted-by":"publisher","award":["HHSN268201800001I"],"award-info":[{"award-number":["HHSN268201800001I"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Background\/Objectives: The anti-M\u00fcllerian hormone (AMH) is a key biomarker of the ovarian reserve, correlating with ovarian follicle count, fertility outcomes, and menopause timing. Understanding its genetic determinants has broad implications for female reproductive health. However, prior genome-wide association studies (GWASs) have focused exclusively on women of European ancestry, limiting insights into diverse populations. Methods: We conducted a GWAS to identify genetic loci associated with circulating AMH levels in a sample of 1185 Samoan women from two independently recruited samples. Using a Cox mixed-effects model we accounted for AMH levels below detectable limits and meta-analysed the summary statistics using a fixed-effect model. To prioritize variants and genes, we used FUMA and performed colocalization and transcriptome-wide association analysis (TWAS). We also assessed whether any previously reported loci were replicated in our GWAS. Results: We identified eleven genome-wide suggestive loci, with the strongest signal at ARID3A (19-946163-G-C; p = 2.32 \u00d7 10\u22127) and replicated rs10093345 near EIF4EBP1. The gene-based testing revealed ARID3A and R3HDM4 as significant genes. Integrating GWAS results with expression quantitative trait loci via TWAS, we detected seven transcriptome-wide significant genes. The lead variant in ARID3A is in high linkage disequilibrium (r2 = 0.79) with the known age-at-menopause variant 19-950694-G-A. Nearby KISS1R is a biologically plausible candidate gene that encodes the kisspeptin receptor, a regulator of ovarian follicle development linked to AMH levels. Conclusions: This study expands our understandings of AMH genetics by focusing on Samoan women. While these findings may be particularly relevant to Pacific Islanders, they hold broader implications for reproductive phenotypes such as the ovarian reserve, menopause timing, and polycystic ovary syndrome.<\/jats:p>","DOI":"10.3390\/genes16070793","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T10:45:08Z","timestamp":1751366708000},"page":"793","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Genome-Wide Association Study of Anti-M\u00fcllerian Hormone (AMH) Levels in Samoan Women"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-6562","authenticated-orcid":false,"given":"Zeynep","family":"Erdogan-Yildirim","sequence":"first","affiliation":[{"name":"Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA"},{"name":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-0833","authenticated-orcid":false,"given":"Jenna C.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"},{"name":"Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohanraj","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry Z.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geralyn","family":"Lambert-Messerlian","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Department of Obstetrics and Gynecology, Brown University, Providence, RI 02912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Take","family":"Naseri","sequence":"additional","affiliation":[{"name":"Naseri & Associates Public Health Consultancy Firm and Family Health Clinic, Matafele WS1339, Samoa"},{"name":"International Health Institute and Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satupaitea","family":"Viali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Oceania University of Medicine, Samoa Campus, Apia P.O. Box 232, Samoa"},{"name":"School of Medicine, National University of Samoa, Apia P.O. Box 1622, Samoa"},{"name":"Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, CT 06520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2601-3454","authenticated-orcid":false,"given":"Nicola L.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, CT 06520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-6970","authenticated-orcid":false,"given":"Stephen T.","family":"McGarvey","sequence":"additional","affiliation":[{"name":"International Health Institute and Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-7228","authenticated-orcid":false,"given":"Daniel E.","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"},{"name":"Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-6717","authenticated-orcid":false,"given":"Ryan L.","family":"Minster","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1210\/jc.2010-0930","article-title":"Serum levels of anti-M\u00fcllerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients","volume":"95","author":"Hagen","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1210\/jc.2011-1502","article-title":"Postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls","volume":"96","author":"Kallio","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/molehr\/gah015","article-title":"Anti-M\u00fcllerian hormone expression pattern in the human ovary: Potential implications for initial and cyclic follicle recruitment","volume":"10","author":"Weenen","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/humrep\/dex226","article-title":"Polycystic ovarian morphology and the diagnosis of polycystic ovary syndrome: Redefining threshold levels for follicle count and serum anti-M\u00fcllerian hormone using cluster analysis","volume":"32","author":"Laven","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ajog.2017.02.027","article-title":"Ovarian reserve testing: A user\u2019s guide","volume":"217","author":"Tal","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/humrep\/dex239","article-title":"Use of the serum anti-M\u00fcllerian hormone assay as a surrogate for polycystic ovarian morphology: Impact on diagnosis and phenotypic classification of polycystic ovary syndrome","volume":"32","author":"Fraissinet","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3389\/fendo.2019.00656","article-title":"Anti-M\u00fcllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome","volume":"10","author":"Abbara","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"616766","DOI":"10.3389\/fendo.2020.616766","article-title":"Use of AMH in the differential diagnosis of anovulatory disorders including PCOS","volume":"11","author":"Capuzzo","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10815-013-0149-0","article-title":"Diagnosis of polycystic ovary syndrome: AMH in combination with clinical symptoms","volume":"31","author":"Sahmay","year":"2014","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4103\/2230-8210.167548","article-title":"Can anti-M\u00fcllerian hormone replace ultrasonographic evaluation in polycystic ovary syndrome? A review of current progress","volume":"19","author":"Singh","year":"2015","journal-title":"Indian. J. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.clinbiochem.2016.02.006","article-title":"Cut-off levels for hyperandrogenemia among Samoan women: An improved methodology for deriving normative data in an obese population","volume":"49","author":"Maredia","year":"2016","journal-title":"Clin. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e23106","DOI":"10.1002\/ajhb.23106","article-title":"Reproductive health, obesity, and cardiometabolic risk factors among Samoan women","volume":"30","author":"Maredia","year":"2018","journal-title":"Am. J. Hum. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/humrep\/der095","article-title":"First assessment of menstrual cycle function and reproductive endocrine status in Samoan women","volume":"26","author":"Roberts","year":"2011","journal-title":"Hum. Reprod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e1000365","DOI":"10.1371\/journal.pgen.1000365","article-title":"Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae","volume":"5","author":"Lowe","year":"2009","journal-title":"PLoS Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ng.3620","article-title":"A thrifty variant in CREBRF strongly influences body mass index in Samoans","volume":"48","author":"Minster","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1073\/pnas.1913157117","article-title":"Evolutionary history of modern Samoans","volume":"17","author":"Harris","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1003132","DOI":"10.1371\/journal.pmed.1003132","article-title":"Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis","volume":"17","author":"Dapas","year":"2020","journal-title":"PLoS Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12864-024-09990-w","article-title":"Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry","volume":"25","author":"Burns","year":"2024","journal-title":"BMC Genom."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/hmg\/ddv465","article-title":"Genome-wide association study identifies common and low-frequency variants at the AMH gene locus that strongly predict serum AMH levels in males","volume":"25","author":"Perry","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1093\/hmg\/ddz015","article-title":"Genome-wide association study of anti-M\u00fcllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan","volume":"28","author":"Ruth","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/humrep\/deac028","article-title":"Genome-wide association study meta-analysis identifies three novel loci for circulating anti-M\u00fcllerian hormone levels in women","volume":"37","author":"Verdiesen","year":"2022","journal-title":"Hum. Reprod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/humrep\/deac082","article-title":"Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients","volume":"37","author":"Moolhuijsen","year":"2022","journal-title":"Hum. Reprod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/humrep\/deae117","article-title":"Circulating anti-M\u00fcllerian hormone levels in pre-menopausal women: Novel genetic insights from a genome-wide association meta-analysis","volume":"39","author":"Karjalainen","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.fertnstert.2008.08.110","article-title":"Variations in serum M\u00fcllerian inhibiting substance between white, black, and Hispanic women","volume":"92","author":"Seifer","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.rbmo.2022.06.023","article-title":"Ethnic discordance in serum anti-M\u00fcllerian hormone in European and Indian healthy women and Indian infertile women","volume":"45","author":"Gromski","year":"2022","journal-title":"Reprod. Biomed. Online"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/bfgp\/elu022","article-title":"Using population isolates in genetic association studies","volume":"13","author":"Hatzikotoulas","year":"2014","journal-title":"Brief. Funct. Genom."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s43586-021-00056-9","article-title":"Genome-wide association studies","volume":"1","author":"Uffelmann","year":"2021","journal-title":"Nat. Rev. Methods Primers"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/sj.ijo.0803675","article-title":"Genome-wide scan for adiposity-related phenotypes in adults from American Samoa","volume":"31","author":"Dai","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1469-1809.2008.00462.x","article-title":"A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans","volume":"72","author":"Dai","year":"2008","journal-title":"Ann. Hum. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ajhb.22553","article-title":"Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study","volume":"26","author":"Hawley","year":"2014","journal-title":"Am. J. Hum. Biol."},{"key":"ref_31","unstructured":"Carlson, J.C., Krishnan, M., Liu, S., Anderson, K.J., Zhang, J.Z., Yapp, T.-A.J., Chiyka, E.A., Dikec, D.A., Cheng, H., and Naseri, T. (2023). Improving imputation quality in Samoans through the integration of population-specific sequences into existing reference panels. medRxiv."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1534\/genetics.119.302940","article-title":"Fast algorithms for conducting large-scale gwas of age-at-onset traits using cox mixed-effects models","volume":"215","author":"He","year":"2020","journal-title":"Genetics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J. R. Stat. Soc. Ser. B Stat. Methodol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/aje\/kwu017","article-title":"Accommodating Measurements Below a Limit of Detection: A Novel Application of Cox Regression","volume":"179","author":"Dinse","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1093\/bioinformatics\/btz567","article-title":"Genetic association testing using the GENESIS R\/Bioconductor package","volume":"35","author":"Gogarten","year":"2019","journal-title":"Bioinformatics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: Fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Paria, S.S., Rahman, S.R., and Adhikari, K. (2022). fastman: A fast algorithm for visualizing GWAS results using Manhattan and Q-Q plots. BioRxiv.","DOI":"10.1101\/2022.04.19.488738"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: Regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e1004722","DOI":"10.1371\/journal.pgen.1004722","article-title":"Integrating functional data to prioritize causal variants in statistical fine-mapping studies","volume":"10","author":"Kichaev","year":"2014","journal-title":"PLoS Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl Variant Effect Predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_44","unstructured":"Bioconducter Package Maintainer (2025, June 15). LiftOver (Version 1.10.0): Changing Genomic Coordinate Systems with Rtracklayer::LiftOver. Available online: https:\/\/www.bioconductor.org\/packages\/release\/workflows\/vignettes\/liftOver\/inst\/doc\/liftov.html."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: Generalized gene-set analysis of GWAS data","volume":"11","author":"Mooij","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"The GTEx consortium (2020). The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science (1979), 369, 1318\u20131330.","DOI":"10.1126\/science.aaz1776"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/gepi.20310","article-title":"A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms","volume":"32","author":"Gao","year":"2008","journal-title":"Genet. Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e1007889","DOI":"10.1371\/journal.pgen.1007889","article-title":"Integrating predicted transcriptome from multiple tissues improves association detection","volume":"15","author":"Barbeira","year":"2019","journal-title":"PLoS Genet."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/bio.2015.0032","article-title":"A novel approach to high-quality postmortem tissue procurement: The GTEx project","volume":"13","author":"Carithers","year":"2015","journal-title":"Biopreserv Biobank"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/gepi.22346","article-title":"Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification","volume":"44","author":"Barbeira","year":"2020","journal-title":"Genet. Epidemiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ajhg.2022.04.005","article-title":"Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility","volume":"109","author":"Hukku","year":"2022","journal-title":"Am. J. Hum. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ajhg.2020.11.012","article-title":"Probabilistic colocalization of genetic variants from complex and molecular traits: Promise and limitations","volume":"108","author":"Hukku","year":"2021","journal-title":"Am. J. Hum. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"eaba2083","DOI":"10.1126\/sciadv.aba2083","article-title":"PhenomeXcan: Mapping the genome to the phenome through the transcriptome","volume":"6","author":"Pividori","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1006646","DOI":"10.1371\/journal.pgen.1006646","article-title":"Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization","volume":"13","author":"Wen","year":"2017","journal-title":"PLoS Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1214\/16-AOAS952","article-title":"Molecular QTL discovery incorporating genomic annotations using Bayesian false discovery rate control","volume":"10","author":"Wen","year":"2016","journal-title":"Ann. Appl. Stat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ajhg.2018.11.008","article-title":"Leveraging polygenic functional enrichment to improve GWAS power","volume":"104","author":"Kichaev","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ng.3412","article-title":"Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair","volume":"47","author":"Day","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_59","first-page":"1078","article-title":"Role of AMH in prediction of menopause","volume":"12","author":"Broekmans","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12916-016-0699-y","article-title":"Back to the basics of ovarian aging: A population-based study on longitudinal anti-M\u00fcllerian hormone decline","volume":"14","author":"Eijkemans","year":"2016","journal-title":"BMC Med."},{"key":"ref_61","first-page":"bax028","article-title":"GeneHancer: Genome-wide integration of enhancers and target genes in GeneCards","volume":"1","author":"Fishilevich","year":"2017","journal-title":"Database"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12958-019-0511-x","article-title":"Reproductive functions of kisspeptin\/KISS1R systems in the periphery","volume":"17","author":"Cao","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1093\/humrep\/deab287","article-title":"Selective loss of kisspeptin signaling in oocytes causes progressive premature ovulatory failure","volume":"37","author":"Ruohonen","year":"2022","journal-title":"Hum. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1101\/gad.1065903","article-title":"GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast","volume":"17","author":"Takayama","year":"2003","journal-title":"Genes. Dev."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Li, Z., and Xu, X. (2019). Post-translational modifications of the mini-chromosome maintenance proteins in DNA replication. Genes, 10.","DOI":"10.3390\/genes10050331"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"625192","DOI":"10.1155\/2015\/625192","article-title":"Age-specific gene expression profiles of rhesus monkey ovaries detected by microarray analysis","volume":"2015","author":"Wei","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"99706","DOI":"10.1371\/journal.pone.0099706","article-title":"Transcriptome profiling of the theca interna from bovine ovarian follicles during atresia","volume":"9","author":"Hatzirodos","year":"2014","journal-title":"PLoS ONE"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/cbin.12208","article-title":"GSE1 promotes the proliferation and migration of lung adenocarcinoma cells by downregulating KLF6 expression","volume":"48","author":"Meng","year":"2024","journal-title":"Cell Biol. Int."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Lee, E.B., Chakravarthi, V.P., Mohamadi, R., Dahiya, V., Vo, K., Ratri, A., Fields, P.E., Marsh, C.A., and Rumi, M.A.K. (2024). Loss of ER\u03b2 disrupts gene regulation in primordial and primary follicles. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25063202"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1210\/en.2018-00001","article-title":"Identification of genes enriched in GnRH neurons by translating ribosome affinity purification and RNAseq in mice","volume":"159","author":"Burger","year":"2018","journal-title":"Endocrinology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1080\/09513590.2021.1950134","article-title":"Effect of anti-M\u00fcllerian hormone in hypothalamic Kiss-1- and GnRH-producing cell models","volume":"37","author":"Oride","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41422-019-0270-4","article-title":"METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing","volume":"30","author":"Chen","year":"2020","journal-title":"Cell Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e0120820","DOI":"10.1128\/mSphere.01208-20","article-title":"Case study of the response of N6-methyladenine DNA modification to environmental stressors in the unicellular eukaryote tetrahymena thermophila","volume":"6","author":"Sheng","year":"2021","journal-title":"MSphere"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"67925","DOI":"10.1007\/s11356-021-16489-4","article-title":"Implications of environmental toxicants on ovarian follicles: How it can adversely affect the female fertility?","volume":"28","author":"Priya","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"100681","DOI":"10.1016\/j.repbio.2022.100681","article-title":"Melatonin enhances spermatogonia activity through promoting KIAA1429-mediated m6A deposition to activate the PI3K\/AKT signaling","volume":"22","author":"Xu","year":"2022","journal-title":"Reprod. Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Szukiewicz, D., Trojanowski, S., Kociszewska, A., and Szewczyk, G. (2022). Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)\u2014Searching for epigenetic factors. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232314663"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1002\/jcp.26507","article-title":"Increased N6-methyladenosine causes infertility is associated with FTO expression","volume":"233","author":"Ding","year":"2018","journal-title":"J. Cell Physiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/s41419-021-04272-9","article-title":"METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice","volume":"12","author":"Mu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.molcel.2019.03.018","article-title":"An adversarial DNA N6-methyladenine-sensor network preserves polycomb silencing","volume":"74","author":"Kweon","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1073\/pnas.0501168102","article-title":"Molecular organization of the Ndc80 complex, an essential kinetochore component","volume":"102","author":"Wei","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1042\/BST20170493","article-title":"Regulation of the meiotic divisions of mammalian oocytes and eggs","volume":"46","author":"Sanders","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1017\/S1431927611000274","article-title":"Ndc80 regulates meiotic spindle organization, chromosome alignment, and cell cycle progression in mouse oocytes","volume":"17","author":"Sun","year":"2011","journal-title":"Microsc. Microanal."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.devcel.2013.02.008","article-title":"Hec1-dependent cyclin B2 stabilization Regulates the G2-M transition and early prometaphase in mouse oocytes","volume":"25","author":"Gui","year":"2013","journal-title":"Dev. Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-022-28403-8","article-title":"Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions","volume":"13","author":"Takenoshita","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13008-020-00065-2","article-title":"The G2-to-M transition from a phosphatase perspective: A new vision of the meiotic division","volume":"15","author":"Lemonnier","year":"2020","journal-title":"Cell Div."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ajhg.2023.07.006","article-title":"Genetic insights into the age-specific biological mechanisms governing human ovarian aging","volume":"110","author":"Ojavee","year":"2023","journal-title":"Am. J. Hum. Genet."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.fertnstert.2014.02.046","article-title":"Comparability of AMH levels among commercially available immunoassays","volume":"101","author":"Su","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/gepi.22189","article-title":"Spinning convincing stories for both true and false association signals","volume":"43","author":"Biedrzycki","year":"2019","journal-title":"Genet. Epidemiol."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/7\/793\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:01:59Z","timestamp":1760032919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/7\/793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":88,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["genes16070793"],"URL":"https:\/\/doi.org\/10.3390\/genes16070793","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.12.05.24318457","asserted-by":"object"}]},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}