{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:48:12Z","timestamp":1783727292079,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes"],"abstract":"<jats:p>Hereditary ataxias are a highly heterogenous group of diseases characterized by loss of coordination. In this study, we investigated a family of random-bred dogs, in which two siblings were affected by a slowly progressive ataxia. They presented with clinical signs of progressive cerebellar ataxia, hypermetria, and absent menace response. The MRI revealed generalized brain atrophy, reduced cortical demarcation, hypoplastic corpus callosum, and cerebellar folia thinning, highly suggestive of a neurodegenerative disorder. We sequenced the genomes of the two affected dogs and their unaffected parents. Filtering for protein-changing variants that had homozygous alternate genotypes in the affected dogs, heterozygous genotypes in the parents, and homozygous reference genotypes in 1576 control genomes yielded a single missense variant in the RAB24 gene, XM_038534663.1:c.239G&gt;T or XP_038390591.1:p.(Gly80Val). Genotypes at this variant showed the expected co-segregation with the ataxia phenotype in the investigated family. The predicted amino acid affects the conserved RabF4 motif. Glycine-80 resides at the protein surface and the introduction of a hydrophobic isopropyl side chain of the mutant valine might impede solvent accessibility. Another missense variant in RAB24, p.Glu38Pro, was previously reported to cause a clinically similar form of cerebellar ataxia in Gordon Setters and Old English Sheepdogs. Taken together, the available data suggest that RAB24:p.Gly80Val represents the causal variant in the studied dogs. To the best of our knowledge, this is only the second report of a potentially pathogenic RAB24 variant in any species and further supports that RAB24 should be considered a candidate gene in human ataxia patients with unclear molecular etiology.<\/jats:p>","DOI":"10.3390\/genes16080934","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T10:58:26Z","timestamp":1754564306000},"page":"934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["RAB24 Missense Variant in Dogs with Cerebellar Ataxia"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7595-2817","authenticated-orcid":false,"given":"Cleo","family":"Schwarz","sequence":"first","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland"},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2997-5730","authenticated-orcid":false,"given":"Jan","family":"Wennemuth","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Veterinary Clinic Hofheim, 65719 Hofheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9868-5703","authenticated-orcid":false,"given":"Julien","family":"Guevar","sequence":"additional","affiliation":[{"name":"Section of Clinical and Comparative Neuropathology, Centre for Clinical Veterinary Medicine, Ludwig Maximilians University, 80539 Munich, Germany"},{"name":"Clinique V\u00e9t\u00e9lys, 1214 Vernier, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"D\u00f6rn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Veterinary Clinic Kalbach, 60437 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-0041","authenticated-orcid":false,"given":"Vidhya","family":"Jagannathan","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-4880","authenticated-orcid":false,"given":"Tosso","family":"Leeb","sequence":"additional","affiliation":[{"name":"Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/jvim.16742","article-title":"Phenotypic and genetic aspects of hereditary ataxia in dogs","volume":"37","author":"Stee","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Forman, O.P., De Risio, L., Stewart, J., Mellersh, C.S., and Beltran, E. (2012). Genome-wide mRNA sequencing of a single canine cerebellar cortical degeneration case leads to the identification of a disease associated SPTBN2 mutation. BMC Genet., 13.","DOI":"10.1186\/1471-2156-13-55"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ky\u00f6stil\u00e4, K., Cizinauskas, S., Sepp\u00e4l\u00e4, E.H., Suhonen, E., Jeserevics, J., Sukura, A., Syrj\u00e4, P., and Lohi, H. (2012). A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002759"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Agler, C., Nielsen, D.M., Urkasemsin, G., Singleton, A., Tonomura, N., Sigurdsson, S., Tang, R., Linder, K., Arepalli, S., and Hernandez, D. (2014). Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1003991"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fenn, J., Boursnell, M., Hitti, R.J., Jenkins, C.A., Terry, R.L., Priestnall, S.L., Kenny, P.J., Mellersh, C.S., and Forman, O.P. (2016). Genome sequencing reveals a splice donor site mutation in the SNX14 gene associated with a novel cerebellar cortical degeneration in the Hungarian Vizsla dog breed. BMC Genet., 17.","DOI":"10.1186\/s12863-016-0433-y"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Christen, M., Zdora, I., Leschnik, M., Jagannathan, V., Puff, C., H\u00fcnerfauth, E., Volk, H.A., Baumg\u00e4rtner, W., Koch, T.C., and Sch\u00e4fer, W. (2023). RALGAPA1 deletion in Belgian Shepherd Dogs with cerebellar ataxia. Genes, 14.","DOI":"10.3390\/genes14081520"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Forman, O.P., De Risio, L., and Mellersh, C.S. (2013). Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064627"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/jvim.12355","article-title":"A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both","volume":"28","author":"Gilliam","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1534\/g3.116.038455","article-title":"A missense variant in KCNJ10 in Belgian Shepherd Dogs affected by spongy degeneration with cerebellar ataxia (SDCA1)","volume":"7","author":"Mauri","year":"2017","journal-title":"G3 Genes Genomes Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ejhg.2016.157","article-title":"The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME\/EAST homologue in Malinois dogs","volume":"25","author":"Stee","year":"2017","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41431-019-0432-3","article-title":"Truncating SLC12A6 variants cause different clinical phenotypes in humans and dogs","volume":"27","author":"Stee","year":"2019","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Letko, A., Dietschi, E., Nieburg, M., Jagannathan, V., Gurtner, C., Oevermann, A., and Dr\u00f6gem\u00fcller, C. (2019). A missense variant in SCN8A in Alpine Dachsbracke Dogs affected by spinocerebellar ataxia. Genes, 10.","DOI":"10.3390\/genes10050362"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1939-1676.2010.0666.x","article-title":"A truncated retrotransposon disrupts the GRM1 coding sequence in Coton de Tulear dogs with Bandera\u2019s neonatal ataxia","volume":"25","author":"Zeng","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00335-014-9547-6","article-title":"Spinocerebellar ataxia in the Italian Spinone dog is associated with an intronic GAA repeat expansion in ITPR1","volume":"26","author":"Forman","year":"2015","journal-title":"Mamm. Genome"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jenkins, C.A., Kalmar, L., Matiasek, K., Mari, L., Ky\u00f6stil\u00e4, K., Lohi, H., Schofield, E.C., Mellersh, C.S., De Risio, L., and Ricketts, S.L. (2020). Characterisation of canine KCNIP4: A novel gene for cerebellar ataxia identified by whole-genome sequencing two affected Norwegian Buhund dogs. PLoS Genet., 16.","DOI":"10.1371\/journal.pgen.1008527"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1023\/A:1005630013448","article-title":"Isolation and characterization of the normal canine beta-galactosidase gene and its mutation in a dog model of GM1-gangliosidosis","volume":"23","author":"Wang","year":"2000","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1534\/genetics.105.042580","article-title":"A duplication in the canine beta-galactosidase gene GLB1 causes exon skipping and GM1-gangliosidosis in Alaskan huskies","volume":"170","author":"Kreutzer","year":"2005","journal-title":"Genetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ygeno.2005.06.005","article-title":"A mutation in canine CLN5 causes neuronal ceroid lipofuscinosis in Border collie dogs","volume":"86","author":"Melville","year":"2005","journal-title":"Genomics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbrc.2004.12.038","article-title":"A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis","volume":"327","author":"Katz","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ymgme.2005.11.005","article-title":"A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis","volume":"87","author":"Awano","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ymgme.2006.02.016","article-title":"A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis","volume":"89","author":"Awano","year":"2006","journal-title":"Mol. Genet. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"14775","DOI":"10.1073\/pnas.0914206107","article-title":"A canine arylsulfatase G (ARSG) mutation leading to a sulfatase deficiency is associated with neuronal ceroid lipofuscinosis","volume":"107","author":"Abitbol","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zeng, R., Guo, J., Bullock, G., Johnson, G.S., and Katz, M.L. (2024). Canine multiple system degeneration associated with sequence variants in SERAC1. Genes, 15.","DOI":"10.20944\/preprints202410.0014.v1"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Katz, M.L., Farias, F.H., Sanders, D.N., Zeng, R., Khan, S., Johnson, G.S., and O\u2019Brien, D.P. (2011). A missense mutation in canine CLN6 in an Australian shepherd with neuronal ceroid lipofuscinosis. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/198042"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ky\u00f6stil\u00e4, K., Syrj\u00e4, P., Jagannathan, V., Chandrasekar, G., Jokinen, T.S., Sepp\u00e4l\u00e4, E.H., Becker, D., Dr\u00f6gem\u00fcller, M., Dietschi, E., and Dr\u00f6gem\u00fcller, C. (2015). A missense change in the ATG4D gene links aberrant autophagy to a neurodegenerative vacuolar storage disease. PLoS Genet., 11.","DOI":"10.1371\/journal.pgen.1005169"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Guo, J., O\u2019Brien, D.P., Mhlanga-Mutangadura, T., Olby, N.J., Taylor, J.F., Schnabel, R.D., Katz, M.L., and Johnson, G.S. (2015). A rare homozygous MFSD8 single-base-pair deletion and frameshift in the whole genome sequence of a Chinese Crested dog with neuronal ceroid lipofuscinosis. BMC Vet. Res., 10.","DOI":"10.1186\/s12917-014-0181-z"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1534\/g3.115.022707","article-title":"A RAB3GAP1 SINE insertion in Alaskan Huskies with polyneuropathy, ocular abnormalities, and neuronal vacuolation (POANV) resembling human Warburg Micro Syndrome 1 (WARBM1)","volume":"6","author":"Wiedmer","year":"2015","journal-title":"Genes Genomes Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1534\/g3.117.043018","article-title":"A SINE Insertion in ATP1B2 in Belgian Shepherd Dogs affected by spongy degeneration with cerebellar ataxia (SDCA2)","volume":"7","author":"Mauri","year":"2017","journal-title":"G3 Genes Genomes Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1534\/g3.118.200376","article-title":"A missense mutation in the vacuolar protein sorting 11 (VPS11) gene is associated with neuroaxonal dystrophy in Rottweiler dogs","volume":"8","author":"Lucot","year":"2018","journal-title":"G3 Genes Genomes Genet."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Christen, M., H\u00f6gler, S., Kleiter, M., Leschnik, M., Weber, C., Thaller, D., Jagannathan, V., and Leeb, T. (2021). Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009716"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/age.13245","article-title":"A PNPLA8 frameshift variant in Australian shepherd dogs with hereditary ataxia","volume":"53","author":"Abitbol","year":"2022","journal-title":"Anim. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Christen, M., Rupp, S., Van Soens, I., Bhatti, S.F.M., Matiasek, K., von Klopmann, T., Jagannathan, V., Madden, I., Batcher, K., and Bannasch, D. (2022). SLC25A12 missense variant in Nova Scotia Duck Tolling Retrievers affected by cerebellar degeneration-myositis complex (CDMC). Genes, 13.","DOI":"10.3390\/genes13071223"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/age.13263","article-title":"Mitochondrial fission factor (MFF) frameshift variant in Bullmastiffs with mitochondrial fission encephalopathy","volume":"53","author":"Christen","year":"2022","journal-title":"Anim. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Christen, M., Gregor, A., Gutierrez-Quintana, R., Bongers, J., Rupp, A., Penderis, J., Shelton, G.D., Jagannathan, V., Zweier, C., and Leeb, T. (2024). NDUFS7 variant in dogs with Leigh syndrome and its functional validation in a Drosophila melanogaster model. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-53314-7"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"108149","DOI":"10.1016\/j.ymgme.2024.108149","article-title":"PCYT2 deficiency in Saarlooswolfdogs with progressive retinal, central, and peripheral neurodegeneration","volume":"141","author":"Christen","year":"2024","journal-title":"Mol. Genet. Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1002\/mds.29977","article-title":"Canine RNF170 single base deletion in a naturally occurring model for human neuroaxonal dystrophy","volume":"39","author":"Cook","year":"2024","journal-title":"Mov. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gerber, M., Fischer, A., Jagannathan, V., Dr\u00f6gem\u00fcller, M., Dr\u00f6gem\u00fcller, C., Schmidt, M.J., Bernardino, F., Manz, E., Matiasek, K., and Rentmeister, K. (2015). A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM). PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0108917"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/age.12834","article-title":"A Comprehensive Biomedical Variant Catalogue Based on Whole Genome Sequences of 582 Dogs and Eight Wolves","volume":"50","author":"Jagannathan","year":"2019","journal-title":"Anim. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bendl, J., Stourac, J., Salanda, O., Pavelka, A., Wieben, E.D., Zendulka, J., Brezovsky, J., and Damborsky, J. (2014). PredictSNP: Robust and accurate consensus classifier for prediction of disease-related mutations. PLoS Comput. Biol., 10.","DOI":"10.1371\/journal.pcbi.1003440"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1038\/s41467-020-19669-x","article-title":"Inferring the molecular and phenotypic impact of amino acid variants with MutPred2","volume":"11","author":"Pejaver","year":"2020","journal-title":"Nat. Comm."},{"key":"ref_43","unstructured":"Mol* 3D Viewer. Available online: https:\/\/www.rcsb.org\/3d-view."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: Making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Hasegawa, D., Tamura, S., Nakamoto, Y., Matsuki, N., Takahashi, K., Fujita, M., Uchida, K., and Yamato, O. (2013). Magnetic resonance findings of the corpus callosum in canine and feline lysosomal storage diseases. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083455"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/jvim.12371","article-title":"Corpus callosal abnormalities in dogs","volume":"28","author":"Volk","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2460\/javma.1980.177.06.538","article-title":"Hereditary cerebellar cortical abiotrophy in the Gordon Setter","volume":"177","author":"Fenner","year":"1980","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"886","DOI":"10.2460\/javma.1981.179.09.886","article-title":"Clinical features of inherited cerebellar degeneration in Gordon Setters","volume":"179","author":"Steinberg","year":"1981","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/00005072-198411000-00003","article-title":"Synaptic neurochemical alterations associated with neuronal degeneration in an inherited cerebellar ataxia of Gordon Setters","volume":"43","author":"Tiemeyer","year":"1984","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00005072-198503000-00005","article-title":"Canine inherited ataxia: Ultrastructural observations","volume":"44","author":"Troncoso","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.2460\/javma.2000.217.1162","article-title":"Cerebellar degeneration in Old English Sheepdogs","volume":"217","author":"Steinberg","year":"2000","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1006\/jmbi.2000.4010","article-title":"The mammalian Rab family of small GTPases: Definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily","volume":"301","author":"Seabra","year":"2000","journal-title":"J. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1074\/jbc.275.6.3848","article-title":"Rab24 is an atypical member of the rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells","volume":"275","author":"Erdman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1034\/j.1600-0854.2002.30704.x","article-title":"Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24","volume":"3","author":"Munafo","year":"2002","journal-title":"Traffic"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/21541248.2017.1317699","article-title":"Roles for RAB24 in autophagy and disease","volume":"9","author":"Eskelinen","year":"2018","journal-title":"Small GTPases"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/s42255-019-0124-x","article-title":"Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity","volume":"1","author":"Seitz","year":"2019","journal-title":"Nat. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: A joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."}],"container-title":["Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/8\/934\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:22:50Z","timestamp":1760034170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4425\/16\/8\/934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":57,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["genes16080934"],"URL":"https:\/\/doi.org\/10.3390\/genes16080934","relation":{},"ISSN":["2073-4425"],"issn-type":[{"value":"2073-4425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]}}}